Phase 1 Ejection Fraction Clinical Trials
11 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–11 of 11 trials
Recruiting
Phase 1
Novel Approaches for Improving Vascular Function in Veterans With HFpEF
InflammationHeart Failure With Preserved Ejection Fraction
VA Office of Research and Development90 enrolled1 locationNCT06312748
Recruiting
Phase 1
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
Heart Failure With Reduced Ejection Fraction
Novartis Pharmaceuticals12 enrolled3 locationsNCT07465653
Recruiting
Phase 1
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Heart Failure With Preserved Ejection Fraction (HFpEF)Heart
Vasa Therapeutics42 enrolled21 locationsNCT07219511
Recruiting
Phase 1Phase 2
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
Heart FailureChronic Kidney DiseasesKidney Diseases+1 more
Northwestern University60 enrolled1 locationNCT05719714
Not Yet Recruiting
Phase 1
Guanethidine for Pulmonary Hypertension with Heart Failure with a Preserved Ejection Fraction (PH-HFpEF)
Heart Failure with a Preserved Ejection Fraction
Alfred Health15 enrolled1 locationACTRN12625000817448
Recruiting
Phase 1
Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart Failure
Heart Failure With Reduced Ejection Fraction
YAP Therapeutics, Inc.24 enrolled1 locationNCT06831825
Recruiting
Phase 1Phase 2
Colchicine in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction
HFpEF - Heart Failure With Preserved Ejection FractionColchicine
I.M. Sechenov First Moscow State Medical University40 enrolled2 locationsNCT05637398
Recruiting
Phase 1
Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Heart Failure With Preserved Ejection Fraction (HFpEF)
Secretome Therapeutics12 enrolled2 locationsNCT06560762
Recruiting
Phase 1Phase 2
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
Heart FailureCongestive Heart FailureHFrEF - Heart Failure With Reduced Ejection Fraction+1 more
Sardocor Corp.57 enrolled5 locationsNCT04703842
Recruiting
Phase 1
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction
Heart Failure With Preserved Ejection FractionHeart Failure, Diastolic
Sardocor Corp.10 enrolled2 locationsNCT06061549
Recruiting
Phase 1
Treatment of Non-ischemic Cardiomyopathies by Intravenous Extracellular Vesicles of Cardiovascular Progenitor Cells
Heart Failure With Reduced Ejection Fraction
Assistance Publique - Hôpitaux de Paris12 enrolled1 locationNCT05774509