Ejection Fraction Clinical Trials

199 recruitingLast updated: July 25, 2026

There are 199 actively recruiting ejection fraction clinical trials across 53 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include Boston, Massachusetts, United States, Chicago, Illinois, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Ejection Fraction Trials at a Glance

199 actively recruiting trials for ejection fraction are listed on ClinicalTrialsFinder across 6 cities in 53 countries. The largest study group is Not Applicable with 79 trials, with the heaviest enrollment activity in Boston, Chicago, and Dallas. Lead sponsors running ejection fraction studies include Mayo Clinic, Massachusetts General Hospital, and The University of Texas Health Science Center at San Antonio.

Browse ejection fraction trials by phase

Treatments under study

About Ejection Fraction Clinical Trials

Looking for clinical trials for Ejection Fraction? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Ejection Fraction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Ejection Fraction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 199 trials

Recruiting
Not Applicable

Ketogenic Diet vs Mixed Diet in Patients With Heart Failure

Heart Failure With Preserved Ejection Fraction
Ohio State University90 enrolled1 locationNCT06081543
Recruiting
Phase 2

Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients

Heart Failure With Reduced Ejection Fraction
Qanatpharma AG60 enrolled2 locationsNCT07695090
Recruiting
Phase 3

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

Heart FailureHeart Failure With Reduced Ejection Fraction
Cytokinetics1,800 enrolled196 locationsNCT06736574
Recruiting
Not Applicable

Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure

Heart Failure With Reduced Ejection Fraction
University of Colorado, Denver2,200 enrolled5 locationsNCT06526988
Recruiting
Phase 2

EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)

Heart Failure With Preserved Ejection Fraction
Massachusetts General Hospital48 enrolled1 locationNCT07202000
Recruiting

Biomarkers for Left Ventricular Reverse Remodeling in Heart Failure (REVERT-HF)

Heart FailureHeart Failure and Reduced Ejection Fraction
Ruijin Hospital Luwan Branch1,740 enrolled1 locationNCT07701876
Recruiting
Phase 2

A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure

Heart Failure With Preserved Ejection Fraction
Mayo Clinic35 enrolled1 locationNCT07083011
Recruiting
Phase 1

A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

Heart Failure With Reduced Ejection Fraction
Novartis Pharmaceuticals12 enrolled4 locationsNCT07465653
Recruiting
Not Applicable

A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

Heart FailureCardiovascular DiseasesHypertension+5 more
Pulnovo Medical, Inc.750 enrolled3 locationsNCT07214376
Recruiting
Not Applicable

Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction
Wake Forest University Health Sciences880 enrolled1 locationNCT05525663
Recruiting

An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting

Chronic Heart Failure With Reduced Ejection Fraction
Bayer1,350 enrolled1 locationNCT06148935
Recruiting
Phase 3

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

ObesityHeart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection Fraction
Amgen5,056 enrolled628 locationsNCT07037459
Recruiting
Phase 4

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score

Heart Failure With Reduced Ejection Fraction
University of Michigan100 enrolled1 locationNCT07490067
Recruiting
Not Applicable

Impact of Barostimulation on Hemodynamics in Adults With Heart Failure

HFrEF - Heart Failure With Reduced Ejection Fraction
Columbia University58 enrolled7 locationsNCT07335510
Recruiting
Not Applicable

The CardioClip Study

Heart Failure With Reduced Ejection FractionMitral Regurgitation
Columbia University60 enrolled1 locationNCT06241430
Recruiting
Not Applicable

ELEVATE-HFpEF Clinical Study

Heart Failure With Preserved Ejection Fraction (HFpEF)
Medtronic Cardiac Rhythm and Heart Failure700 enrolled46 locationsNCT06678841
Recruiting
Not Applicable

Assessment of CCM in HF With Higher Ejection Fraction

Heart FailureHeart Failure With Preserved Ejection FractionDiastolic Heart Failure+2 more
Impulse Dynamics1,500 enrolled105 locationsNCT05064709
Recruiting
Phase 2Phase 3

A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction

Diabetes Mellitus, Type 2Heart Failure With Preserved Ejection FractionHeart Failure, Diastolic+2 more
University of Leicester63 enrolled3 locationsNCT05887271
Recruiting
Phase 2Phase 3

Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure

ObesityWeight LossHeart Failure With Reduced Ejection Fraction+1 more
Jens D Hove, MD,PHD100 enrolled1 locationNCT06423599
Recruiting

Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG

Heart Failure With Reduced Ejection FractionHypertension, Pulmonary
Eko Devices, Inc.3,850 enrolled4 locationsNCT07087613