Ejection Fraction Clinical Trials

188 recruitingLast updated: May 13, 2026

There are 188 actively recruiting ejection fraction clinical trials across 52 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include Boston, Massachusetts, United States, Dallas, Texas, United States, Chicago, Illinois, United States. Updated daily from ClinicalTrials.gov.


Ejection Fraction Trials at a Glance

188 actively recruiting trials for ejection fraction are listed on ClinicalTrialsFinder across 6 cities in 52 countries. The largest study group is Not Applicable with 73 trials, with the heaviest enrollment activity in Boston, Dallas, and Chicago. Lead sponsors running ejection fraction studies include Mayo Clinic, The University of Texas Health Science Center at San Antonio, and University of Leicester.

Browse ejection fraction trials by phase

Treatments under study

About Ejection Fraction Clinical Trials

Looking for clinical trials for Ejection Fraction? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Ejection Fraction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Ejection Fraction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 188 trials

Recruiting
Phase 2

A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction
Shandong Suncadia Medicine Co., Ltd.48 enrolled1 locationNCT07269717
Recruiting
Phase 2

CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation

HFpEF - Heart Failure With Preserved Ejection FractionFontan CirculationSingle Ventricle Heart Disease
Mayo Clinic27 enrolled1 locationNCT06762964
Recruiting
Not Applicable

Assessment of CCM in HF With Higher Ejection Fraction

Heart FailureHeart Failure With Preserved Ejection FractionDiastolic Heart Failure+2 more
Impulse Dynamics1,500 enrolled105 locationsNCT05064709
Recruiting
Phase 3

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

ObesityHeart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection Fraction
Amgen5,056 enrolled603 locationsNCT07037459
Recruiting
Not Applicable

Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

ObesityHeart Failure With Preserved Ejection Fraction
University of Texas Southwestern Medical Center78 enrolled1 locationNCT05723679
Recruiting
Not Applicable

ELEVATE-HFpEF Clinical Study

Heart Failure With Preserved Ejection Fraction (HFpEF)
Medtronic Cardiac Rhythm and Heart Failure700 enrolled42 locationsNCT06678841
Recruiting

The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction (HFpEF)
University of Leicester130 enrolled1 locationNCT06768437
Recruiting

Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction

Type 2 DiabetesHeart Failure With Preserved Ejection Fraction
University of Leicester60 enrolled1 locationNCT06652763
Recruiting
Phase 3

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

Heart FailureHeart Failure With Reduced Ejection Fraction
Cytokinetics1,800 enrolled185 locationsNCT06736574
Recruiting
Phase 4

Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction

Heart Failure Preserved Ejection FractionEpicardial Adipose Tissue
University of Virginia192 enrolled1 locationNCT07178145
Recruiting
Phase 2

Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction

Coronary Artery DiseaseHeart Failure With Preserved Ejection Fraction (HFpEF)
King's College London350 enrolled1 locationNCT07560436
Recruiting
Not Applicable

Developing a Digital Aid to Improve ICD Decisions

Heart Failure and Reduced Ejection Fraction
Stanford University600 enrolled2 locationsNCT07084142
Recruiting
Not Applicable

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection FractionConcentric Hypertrophy
Medtronic Cardiac Rhythm and Heart Failure105 enrolled8 locationsNCT05839730
Recruiting
Phase 2

A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure

Heart Failure With Preserved Ejection Fraction
Mayo Clinic35 enrolled1 locationNCT07083011
Recruiting
Not Applicable

Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)

Heart Failure With Reduced Ejection Fraction
Beijing Anzhen Hospital252 enrolled6 locationsNCT07352891
Recruiting
Phase 1

Novel Approaches for Improving Vascular Function in Veterans With HFpEF

InflammationHeart Failure With Preserved Ejection Fraction
VA Office of Research and Development90 enrolled1 locationNCT06312748
Recruiting

An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting

Chronic Heart Failure With Reduced Ejection Fraction
Bayer1,350 enrolled1 locationNCT06148935
Recruiting

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction
Mayo Clinic400 enrolled1 locationNCT07401771
Recruiting
Phase 2

SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

Heart Failure With Preserved Ejection Fraction
University of Pennsylvania53 enrolled1 locationNCT05138575
Recruiting
Phase 3

Selenium Intervention Registry Randomized Trial in Heart Failure

Cognitive functioningHeart FailureHeart Failure and Reduced Ejection Fraction+4 more
Skane University Hospital4,326 enrolled11 locationsNCT07543562