Phase 3 Esophageal Squamous Cell Carcinoma Clinical Trials
19 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–19 of 19 trials
Recruiting
Phase 3
Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer
Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8+10 more
NRG Oncology300 enrolled95 locationsNCT03801876
Recruiting
Phase 3
A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
Esophageal Squamous Cell Carcinoma
Daiichi Sankyo510 enrolled88 locationsNCT06644781
Recruiting
Phase 3
Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO
Triple-Negative Breast CancerCervical CancerUrothelial Carcinoma+12 more
UNICANCER646 enrolled40 locationsNCT05078047
Recruiting
Phase 3
A Randomized Controlled Trial Evaluating of Prophylactic Irradiation in CRT for cT1bN0M0 ESCC
Esophageal Squamous Cell Carcinoma
National Cancer Center, Japan280 enrolled1 locationNCT04328948
Recruiting
Phase 2Phase 3
Optimizing Neoadjuvant Treatment Regimens for Locally Advanced Esophageal Squamous Cell Carcinoma
Locally Advanced Esophageal Squamous Cell Carcinoma
Peking Union Medical College Hospital120 enrolled1 locationNCT06907602
Recruiting
Phase 3
Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer
Esophageal Squamous Cell Carcinoma
Karolinska University Hospital1,020 enrolled12 locationsNCT04460352
Recruiting
Phase 3
A Study of Chemoradiation in Combination with Tislelizumab As First Line Treatment in Participants with Advanced Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma
Renmin Hospital of Wuhan University155 enrolled1 locationNCT05919030
Recruiting
Phase 3
Camrelizumab Plus Neoadjuvant Chemotherapy or Chemoradiotherapy Versus Chemoradiotherapy in Resectable ESCC.
Resectable Esophageal Squamous Cell Carcinoma
Zhigang Li426 enrolled5 locationsNCT05043688
Recruiting
Phase 3
Adjuvant Sintilimab for Locally Advanced Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma
Henan Cancer Hospital219 enrolled2 locationsNCT05495152
Recruiting
Phase 3
A Study to Compare the Efficacy and Safety of LY01015 and Opdivo® Combined Respectively With Chemotherapy in Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma
Shandong Boan Biotechnology Co., Ltd510 enrolled1 locationNCT06022861
Recruiting
Phase 3
Sintilimab With Chemotherapy Plus PEG-rhG-GSF for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital with Nanjing Medical University40 enrolled1 locationNCT06563869
Recruiting
Phase 2Phase 3
Sintilimab and Chemotherapy Sequential Radiotherapy in Advanced Esophageal Cancer
Metastatic Esophageal Squamous Cell Carcinoma
Qingdao Central Hospital90 enrolled2 locationsNCT06138028
Recruiting
Phase 3
Local Therapy for Oligometastatic ESCC Patients Treated With PD-1 Inhibitor
Esophageal Squamous Cell CarcinomaOligometastatic DiseaseRadiotherapy
Fudan University354 enrolled1 locationNCT06190782
Recruiting
Phase 2Phase 3
A Study of Neoadjuvant Therapy for the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma
Neoadjuvant TherapyEsophageal Squamous Cell Carcinoma
Army Medical Center of PLA266 enrolled1 locationNCT06354530
Recruiting
Phase 3
A Study of KC1036 Versus Investigator's Choice of Chemotherapy in Patients With Advanced Esophageal Cancer
Esophageal Squamous Cell Carcinoma
Beijing Konruns Pharmaceutical Co., Ltd.490 enrolled1 locationNCT06194734
Recruiting
Phase 3
Neoadjuvant Chemotherapy Versus Neoadjuvant Chemoradiotherapy for Resectable Locally Advanced Esophageal Cancer (HCHTOG1903)
Esophageal Squamous Cell Carcinoma
Henan Cancer Hospital456 enrolled1 locationNCT04138212
Recruiting
Phase 2Phase 3
Neoadjuvant Immunotherapy Plus CRT Versus Neoadjuvant CRT for Locally Advanced Resectable ESCC
Esophageal Squamous Cell Carcinoma Stage IIEsophageal Squamous Cell Carcinoma Stage III
Shanghai Zhongshan Hospital176 enrolled1 locationNCT04973306
Recruiting
Phase 3
Pembrolizumab Plus Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiotherapy for Locally Advanced ESCC (KEYSTONE-002)
Esophageal Squamous Cell Carcinoma
Tianjin Medical University Cancer Institute and Hospital342 enrolled1 locationNCT04807673
Recruiting
Phase 3
Study Compare Adjuvant Chemotherapy, Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma
Esophageal Squamous Cell Carcinoma
Fujian Medical University Union Hospital819 enrolled1 locationNCT04009265