Phase 2 gastrointestinal Clinical Trials
72 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 72 trials
Recruiting
Phase 2
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
Pancreatic Neuroendocrine TumorVon Hippel-Lindau DiseasePheochromocytoma/Paraganglioma+2 more
Merck Sharp & Dohme LLC355 enrolled84 locationsNCT04924075
Recruiting
Phase 1Phase 2
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Gastrointestinal Cancer
Merck Sharp & Dohme LLC180 enrolled62 locationsNCT06596694
Recruiting
Phase 1Phase 2
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed
Gastrointestinal Neoplasms
GlaxoSmithKline451 enrolled85 locationsNCT06885034
Recruiting
Phase 2
KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)
GISTGIST - Gastrointestinal Stromal TumorGastrointestinal Tumors+2 more
Kumquat Biosciences Inc.46 enrolled16 locationsNCT07406633
Recruiting
Phase 1Phase 2
Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma
Pancreatic CancerGastric CancerGastric (Stomach) Cancer+11 more
BigHat Biosciences, Inc.164 enrolled1 locationNCT07529808
Recruiting
Phase 2
Study to Assess the Efficacy and Safety of Rina-S in Participants With Advanced Gastrointestinal (GI) Cancers
Gastrointestinal Cancers
Genmab160 enrolled2 locationsNCT07539311
Recruiting
Phase 1Phase 2
Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy
PheochromocytomaGastrointestinal Neuroendocrine TumorsSomatostatin Receptor Positive+1 more
National Cancer Institute (NCI)66 enrolled1 locationNCT06427798
Recruiting
Phase 2
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer
Breast CancerOvarian CancerNon-small Cell Lung Cancer+4 more
National Cancer Institute (NCI)285 enrolled1 locationNCT03412877
Recruiting
Phase 1Phase 2
Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer
Gastrointestinal Cancer
Zhejiang Doer Biologics Co., Ltd.186 enrolled1 locationNCT07056777
Recruiting
Phase 2
A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers
Gastrointestinal Cancer
Memorial Sloan Kettering Cancer Center216 enrolled8 locationsNCT05789485
Recruiting
Phase 2
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Breast CancerColorectal, CancerLung Cancer+13 more
Brigham and Women's Hospital134 enrolled2 locationsNCT04899908
Recruiting
Phase 2Phase 3
Efficacy and Safety of NB003 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
GIST - Gastrointestinal Stromal TumorAdvanced
Ningbo Newbay Technology Development Co., Ltd255 enrolled32 locationsNCT07379047
Recruiting
Phase 2
Safety and Efficacy of Crofelemer in Adult Patients With Short Bowel Syndrome and Intestinal Failure (SBS-IF) Without Colon-in-continuity (CIC)
Short Bowel SyndromeFunctional Gastrointestinal DisordersPost-Op Complication+2 more
Napo Therapeutics, S.p.A.18 enrolled8 locationsNCT06904872
Recruiting
Phase 2
Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.
Gynecologic CancersEsophageal CancerGastrointestinal Cancers
John Waters50 enrolled1 locationNCT07039526
Recruiting
Phase 1Phase 2
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
Pancreatic CancerGastric CancerColon Cancer+2 more
National Cancer Institute (NCI)110 enrolled1 locationNCT03190941
Recruiting
Phase 2
PH 2 Pemigatinib in SDH-deficient GIST
SDH Gene MutationGastrointestinal Stromal Tumor
Dana-Farber Cancer Institute24 enrolled1 locationNCT07434843
Recruiting
Phase 1Phase 2
A Study of DB-1324 in Advanced/Metastatic Gastrointestinal Tumors
Gastrointestinal Cancer
DualityBio Inc.127 enrolled9 locationsNCT07263594
Recruiting
Phase 2
Romiplostim N01 Plus ATRA for Persistent Isolated Chemotherapy-Induced Thrombocytopenia After Complete Remission of Gastrointestinal Solid Tumors
Colorectal, CancerPancreatic CancerGastrointestinal Neoplasms+2 more
Peking University People's Hospital220 enrolled1 locationNCT07586813
Recruiting
Phase 1Phase 2
A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
Carcinoma, Non-Small Cell LungSquamous Cell Carcinoma of Head and NeckOvarian Neoplasms+8 more
Cancer Research UK167 enrolled4 locationsNCT06380816
Recruiting
Phase 1Phase 2
COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER
Colorectal, CancerStenosisFibrosis, Liver+4 more
Massachusetts General Hospital80 enrolled1 locationNCT05692024