gastrointestinal Clinical Trials

369 recruitingLast updated: July 25, 2026

There are 369 actively recruiting gastrointestinal clinical trials across 54 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Boston, Massachusetts, United States, Houston, Texas, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


gastrointestinal Trials at a Glance

369 actively recruiting trials for gastrointestinal are listed on ClinicalTrialsFinder across 6 cities in 54 countries. The largest study group is Not Applicable with 139 trials, with the heaviest enrollment activity in Boston, Houston, and New York. Lead sponsors running gastrointestinal studies include National Cancer Institute (NCI), Chinese University of Hong Kong, and Asan Medical Center.

Browse gastrointestinal trials by phase

Treatments under study

About gastrointestinal Clinical Trials

Looking for clinical trials for gastrointestinal? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new gastrointestinal trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about gastrointestinal clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 369 trials

Recruiting
Phase 3

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

Colorectal NeoplasmsNeoplasms by SiteGastrointestinal Neoplasms+7 more
Pfizer800 enrolled285 locationsNCT07222800
Recruiting

DESTINY-PANTUMOUR04

Liver CancerEsophageal CancerPancreatic Cancer+24 more
AstraZeneca100 enrolled18 locationsNCT07124000
Recruiting
Not Applicable

Prebiotic Inulin for Late-Reproductive Individuals

Insulin ResistanceObesity, OverweightMicrobiota+9 more
George Washington University27 enrolled1 locationNCT07724522
Recruiting
Phase 2

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Pancreatic Neuroendocrine TumorVon Hippel-Lindau DiseasePheochromocytoma/Paraganglioma+2 more
Merck Sharp & Dohme LLC355 enrolled84 locationsNCT04924075
Recruiting
Phase 1

Study of DCC-2618 in Patients With GIST After at Least 3 Prior Treatments

Gastrointestinal Stromal Tumors
Ono Pharmaceutical Co., Ltd.10 enrolled2 locationsNCT07618377
Recruiting

Comprehensive HHT Outcomes Registry of the United States (CHORUS)

Gastrointestinal BleedingTelangiectasiaArteriovenous Malformations+4 more
Cure HHT10,000 enrolled16 locationsNCT06259292
Recruiting

Evaluation of Patients With Gastrointestinal Disease

Gastrointestinal DiseasesLower GI Disease
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)4,000 enrolled1 locationNCT05041374
Recruiting

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Gastric CancerGastric NeoplasmGastrointestinal Stromal Tumor (GIST)+2 more
National Cancer Institute (NCI)400 enrolled1 locationNCT04557969
Recruiting
Phase 1Phase 2

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

Gastrointestinal Cancer
Merck Sharp & Dohme LLC180 enrolled62 locationsNCT06596694
Recruiting
Not Applicable

Performance Characteristics and Technical Outcomes of Single-use Gastroscopes Used Bedside Versus Reusable Gastroscopes Used in the Endoscopy Unit Evaluated in Subacute Patients

Upper Gastrointestinal Disorder
Zealand University Hospital180 enrolled1 locationNCT06771102
Recruiting
Not Applicable

Goals of Care Discussion for Patients With Advanced Lung and Gastrointestinal Cancer in the Emergency Department of a Comprehensive Cancer Center

Lung CancerGastrointestinal Cancer
M.D. Anderson Cancer Center200 enrolled1 locationNCT06420206
Recruiting
Not Applicable

A Study on Gastrointestinal Cancer Screening Using a Multi-Targeted Combined Detection Model: A Multi-center Prospective Randomized Controlled Trial

Gastrointestinal Tumors
Xijing Hospital10,000 enrolled6 locationsNCT07712107
Recruiting
Phase 1Phase 2

A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed

Gastrointestinal Neoplasms
GlaxoSmithKline451 enrolled85 locationsNCT06885034
Recruiting
Phase 3

Electroacupuncture for Chemotherapy-Induced GI Symptom Clusters in Breast Cancer

Standard Quadruple Antiemetic TherapyElectroacupunctureChemotherapy-induced Gastrointestinal Symptom Cluster
Jiuda Zhao388 enrolled1 locationNCT06952920
Recruiting
Not Applicable

Effect of Fecal Microbiota Transplantation (FMT) in Pediatric Functional Gastrointestinal Disorders

Functional Gastrointestinal Disorders
Biao Zou100 enrolled1 locationNCT05753774
Recruiting

LRG GIST Patient Registry

GISTGIST - Gastrointestinal Stromal TumorGastrointestinal Stromal Tumor (GIST)
The Life Raft Group5,000 enrolled1 locationNCT07697248
Recruiting
Phase 2

KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

GISTGIST - Gastrointestinal Stromal TumorGastrointestinal Tumors+2 more
Kumquat Biosciences Inc.46 enrolled16 locationsNCT07406633
Recruiting
Phase 1

Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies

Colorectal, CancerOvarian CancerPeritoneal Carcinomatosis+4 more
National Cancer Institute (NCI)60 enrolled1 locationNCT04847063
Recruiting
Not Applicable

The Effect of Humiome® Post LB on Gut COMFort in healthY Adult Volunteers

Gastrointestinal SymptomsGI IssuesBowel Movements
dsm-firmenich Switzerland AG250 enrolled1 locationNCT06937814
Recruiting
Phase 3

Tegoprazan for Prevention of Gastrointestinal Complication in Ischemic Stroke Patients on Antiplatelet Therapy (TegoStroke)

Gastrointestinal BleedingIschemic StrokeCerebrovascular Disease+3 more
Hanyang University Guri Hospital1,524 enrolled24 locationsNCT07687706