gastrointestinal Clinical Trials

346 recruitingLast updated: May 13, 2026

There are 346 actively recruiting gastrointestinal clinical trials across 51 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Boston, Massachusetts, United States, Houston, Texas, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


gastrointestinal Trials at a Glance

346 actively recruiting trials for gastrointestinal are listed on ClinicalTrialsFinder across 6 cities in 51 countries. The largest study group is Not Applicable with 130 trials, with the heaviest enrollment activity in Boston, Houston, and New York. Lead sponsors running gastrointestinal studies include National Cancer Institute (NCI), Chinese University of Hong Kong, and Asan Medical Center.

Browse gastrointestinal trials by phase

Treatments under study

About gastrointestinal Clinical Trials

Looking for clinical trials for gastrointestinal? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new gastrointestinal trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about gastrointestinal clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 346 trials

Recruiting
Phase 2

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Pancreatic Neuroendocrine TumorVon Hippel-Lindau DiseasePheochromocytoma/Paraganglioma+2 more
Merck Sharp & Dohme LLC322 enrolled84 locationsNCT04924075
Recruiting
Phase 1

A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers

Colorectal NeoplasmsGastrointestinal Neoplasms
Janssen Research & Development, LLC220 enrolled11 locationsNCT06663319
Recruiting
Phase 2

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Breast CancerOvarian CancerNon-small Cell Lung Cancer+4 more
National Cancer Institute (NCI)285 enrolled1 locationNCT03412877
Recruiting
Not Applicable

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

Esophageal CarcinomaGastric CarcinomaGastroesophageal Junction Carcinoma+7 more
Alliance for Clinical Trials in Oncology420 enrolled316 locationsNCT07283939
Recruiting

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

Breast CancerLung CancerMelanoma+7 more
University Health Network, Toronto7,000 enrolled1 locationNCT07524114
Recruiting
Not Applicable

A Novel Two-Tooth Clip for ESD and EFTR of GIST: A Prospective RCT

GIST - Gastrointestinal Stromal Tumor
Affiliated Hospital to Academy of Military Medical Sciences60 enrolled1 locationNCT07581977
Recruiting
Phase 1Phase 2

A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer

Carcinoma, Non-Small Cell LungSquamous Cell Carcinoma of Head and NeckOvarian Neoplasms+8 more
Cancer Research UK167 enrolled4 locationsNCT06380816
Recruiting
Phase 2

Study to Assess the Efficacy and Safety of Rina-S in Participants With Advanced Gastrointestinal (GI) Cancers

Gastrointestinal Cancers
Genmab160 enrolled2 locationsNCT07539311
Recruiting

DESTINY-PANTUMOUR04

Liver CancerEsophageal CancerPancreatic Cancer+24 more
AstraZeneca100 enrolled17 locationsNCT07124000
Recruiting
Not Applicable

Gastrointestinal Response of Pediatric Cystic Fibrosis Patients on Mediterranean Diet

Cystic Fibrosis (CF)Cystic Fibrosis Gastrointestinal Disease
Dartmouth-Hitchcock Medical Center20 enrolled2 locationsNCT07223255
Recruiting

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Gastric CancerGastric NeoplasmGastrointestinal Stromal Tumor (GIST)+2 more
National Cancer Institute (NCI)400 enrolled1 locationNCT04557969
Recruiting
Phase 1Phase 2

COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

Colorectal, CancerStenosisFibrosis, Liver+4 more
Massachusetts General Hospital80 enrolled1 locationNCT05692024
Recruiting
Not Applicable

Exclude or Expose in Irritable Bowel Syndrome: What Works for Whom and How?

Gastrointestinal DiseaseIntestinal DiseasesIrritable Bowel Syndrome (IBS)
University of Melbourne235 enrolled1 locationNCT06940596
Recruiting

Integrated Cancer Repository for Cancer Research

Breast CancerLiver CancerEsophageal Cancer+47 more
University of Nebraska999,999 enrolled42 locationsNCT02012699
Recruiting
Phase 1

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

Metastatic CancerGastrointestinal NeoplasmsGastrointestinal Diseases+2 more
IDRX, Inc., a wholly owned subsidiary of GSK, LLC278 enrolled31 locationsNCT05489237
Recruiting
Not Applicable

The Influence of Feeding Source on the Gut Microbiome and Time to Full Feeds in Neonates With Congenital Gastrointestinal Pathologies

gastroschisisHirschsprung DiseaseGastrointestinal Complication+3 more
Seattle Children's Hospital116 enrolled1 locationNCT06072976
Recruiting
Not Applicable

Efficacy of LcS-Fermented Milk on Constipation-Related Symptoms in Filipino Adults

Gastrointestinal DiscomfortConstipation
University of Santo Tomas60 enrolled1 locationNCT07083596
Recruiting

Frailty in Patients With Gastrointestinal Cancer Who Are Undergoing Major Surgery

Gastrointestinal Cancer
The Guthrie Clinic100 enrolled2 locationsNCT05694338
Recruiting

Video Capsule Endoscopy for Detection of Gastrointestinal Bleeding in the Small Bowel

Gastrointestinal Bleeding
University Hospital Freiburg1,300 enrolled1 locationNCT05949268
Recruiting
Not Applicable

Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production

Gastrointestinal MicrobiomeHydrogen Sulfide
University of Colorado, Denver25 enrolled1 locationNCT06802276