Phase 3 Glioblastoma Clinical Trials
20 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 20 trials
Recruiting
Phase 2Phase 3
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
Glioblastoma
Global Coalition for Adaptive Research2,250 enrolled63 locationsNCT03970447
Recruiting
Phase 3
Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study
First Progression of Glioblastoma
European Organisation for Research and Treatment of Cancer - EORTC411 enrolled45 locationsNCT05904119
Recruiting
Phase 3
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
GlioblastomaGBMRecurrent Glioblastoma
CarThera560 enrolled48 locationsNCT05902169
Recruiting
Phase 3
Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM
Brain CancerGlioblastomaGBM+4 more
Northwell Health432 enrolled1 locationNCT05271240
Recruiting
Phase 3
Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care
Glioblastoma
GT Medical Technologies, Inc.766 enrolled5 locationsNCT07195591
Recruiting
Phase 3
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
Glioblastoma
NovoCure GmbH741 enrolled93 locationsNCT06556563
Recruiting
Phase 3
Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma
GlioblastomaNeoplastic DiseaseGlioblastoma (GBM)+3 more
Telix Pharmaceuticals (Innovations) Pty Limited50 enrolled4 locationsNCT07100730
Recruiting
Phase 3
Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma
Glioblastoma, IDH-wildtypeMGMT-Methylated Glioblastoma
Vastra Gotaland Region200 enrolled20 locationsNCT06419946
Recruiting
Phase 3
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
NeoplasmsBrain TumorGlioblastoma+5 more
NaviFUS Corporation32 enrolled2 locationsNCT06496971
Recruiting
Phase 3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Brain TumorGlioblastomaGBM+1 more
Ivy Brain Tumor Center450 enrolled95 locationsNCT06388733
Recruiting
Phase 3
Treatment Intensification With Temozolomide in Adults With a Glioblastoma
Glioblastoma
Centre Oscar Lambret486 enrolled19 locationsNCT03663725
Recruiting
Phase 3
Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma Patients
Glioblastoma
Jonsson Comprehensive Cancer Center15 enrolled1 locationNCT07461948
Not Yet Recruiting
Phase 3
The CONCISE trial: Condensed Chemoradiotherapy Schedule for Glioblastoma
Brain CancerGlioblastoma
The Walter and Eliza Hall Institute of Medical Research (WEHI)330 enrolled1 locationACTRN12626000036314
Recruiting
Phase 2Phase 3
Antisecretory Factor Glioblastoma Phase 2
Glioblastoma
Peter Siesjö300 enrolled1 locationNCT05669820
Not Yet Recruiting
Phase 3
A Phase III Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma ( IPAX-3 ) - Part 1
Glioblastoma
Telix Pharmaceuticals18 enrolled3 locationsACTRN12625000934448
Recruiting
Phase 3
Anterior Temporal Lobectomy in Temporal Glioblastoma
Newly Diagnosed GlioblastomaTemporal Lobe
University Hospital, Bonn178 enrolled1 locationNCT07021339
Recruiting
Phase 3
Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma
Glioblastoma
Severance Hospital178 enrolled1 locationNCT05439278
Recruiting
Phase 2Phase 3
Dendritic Cell Immunotherapy Against Cancer Stem Cells in Glioblastoma Patients Receiving Standard Therapy
Glioblastoma
Oslo University Hospital60 enrolled1 locationNCT03548571
Completed
Phase 3
The Multi-Arm GlioblastoMa Australasia (MAGMA) Trial is a platform trial that will assess a number of options in standard of care for the management of glioblastoma. Initial questions of interest are: QUESTION 1 whether or not to give a cycle of temozolomide prior to chemoradiotherapy and QUESTION 2: whether to give 6 cycles of temozolomide after chemoradiotherapy, or continue monthly treatment until disease progression
Glioblastoma
NHMRC Clinical Trials Centre (CTC), University of Sydney300 enrolled28 locationsACTRN12620000048987
Completed
Phase 3
Phase III Trial of Extended Temozolomide in Newly Diagnosed Glioblastoma
Brain CancerGlioblastoma
The Walter and Eliza Hall Institute of Medical Research315 enrolled15 locationsACTRN12618001944224