Phase 2 Granuloma Clinical Trials
12 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–12 of 12 trials
Recruiting
Phase 2
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
Immune DysregulationPrimary Immune Regulatory DisorderChronic Granulomatous Disease+12 more
Paul Szabolcs25 enrolled1 locationNCT07284641
Recruiting
Phase 1Phase 2
Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists
Chronic Granulomatous Disease
National Institute of Allergy and Infectious Diseases (NIAID)50 enrolled1 locationNCT05463133
Recruiting
Phase 1Phase 2
Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease
X-Linked Chronic Granulomatous Disease
Ensoma15 enrolled9 locationsNCT06876363
Recruiting
Phase 1Phase 2
Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease
Chronic Granulomatous Disease (CGD)X-Linked Chronic Granulomatous Disease
National Institute of Allergy and Infectious Diseases (NIAID)10 enrolled1 locationNCT06325709
Recruiting
Phase 1Phase 2
Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis
Chronic Granulomatous Disease-associated Colitis
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled1 locationNCT05333471
Recruiting
Phase 2
Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis
Eosinophilic Granulomatosis With PolyangiitisChurg-Strauss Syndrome
NS Pharma, Inc.45 enrolled34 locationsNCT06046222
Recruiting
Phase 2
Obinutuzumab for Remission Induction in Patients With Relapsing PR3-ANCA Granulomatosis With Polyangiitis
Granulomatosis With Polyangiitis
Assistance Publique - Hôpitaux de Paris33 enrolled1 locationNCT06940661
Recruiting
Phase 2Phase 3
A Study to Evaluate the Efficacy and Safety of SHR-1703 in Subjects With Eosinophilic Granulomatosis With Polyangiitis （EGPA）
Eosinophilic Granulomatosis With Polyangiitis
Guangdong Hengrui Pharmaceutical Co., Ltd166 enrolled2 locationsNCT05979051
Recruiting
Phase 2
Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
Langerhan's Cell HistiocytosisJuvenile XanthogranulomaErdheim-Chester Disease+4 more
Carl Allen90 enrolled12 locationsNCT04079179
Recruiting
Phase 2
Combination of Ibuprofen, G-CSF and Plerixafor as Stem Cells Mobilization Regimen in Patients Affected by X-CGD
Chronic Granulomatous Disease X-linked (X-CGD)
IRCCS San Raffaele3 enrolled2 locationsNCT03055247
Recruiting
Phase 2
Mirdametinib in Histiocytic Disorders
Histiocytic DisordersRosai-Dorfman Disease (RDD)Langerhans Cell Histiocytosis (LCH)+1 more
Children's Hospital Medical Center, Cincinnati40 enrolled1 locationNCT06153173
Recruiting
Phase 1Phase 2
Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE)
Systemic Lupus ErythematosusAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisSjogren's Syndrome+6 more
Essen Biotech75 enrolled1 locationNCT06350110