Phase 1 HAE Clinical Trials
28 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 28 trials
Recruiting
Phase 1Phase 2
Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients
Haemodynamic Rebound
New Valley University2 enrolled1 locationNCT06490731
Recruiting
Phase 1
A Research Study Looking at How Different Doses of Study Medicine (Inno8) Work in the Body of People With Haemophilia A
Haemophilia A
Novo Nordisk A/S30 enrolled33 locationsNCT07220564
Recruiting
Phase 1Phase 2
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).
ParagangliomaPheochromocytomaSolid Tumor Cancer+17 more
Fundación de investigación HM25 enrolled1 locationNCT06607692
Recruiting
Phase 1
A Study of AZD2962, an IRAK4 Inhibitor (IRAK4 [a Body Protein] Blocker), in Participants With Haematologic Neoplasms (Blood Cancers)
Haematologic Neoplasms
AstraZeneca72 enrolled21 locationsNCT07064122
Recruiting
Phase 1
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
chronic strokeStrokeIschemic Stroke+9 more
Johns Hopkins University20 enrolled1 locationNCT07053917
Recruiting
Phase 1
A Phase 1 Study to Assess STP938 as a Monotherapy in Adults With High Risk Essential Thrombocythaemia
Essential Thrombocythaemia
Step Pharma, SAS20 enrolled13 locationsNCT06786234
Recruiting
Phase 1
Phase I Study of CTL Anti-DP Infusion Post-hematopoietic Stem Cell Transplantation
Haematologic Disease
Nantes University Hospital6 enrolled1 locationNCT04180059
Recruiting
Phase 1
A Research Study Looking at How Food Intake Affects Inno8 in the Body of Healthy People
Haemophilia A
Novo Nordisk A/S80 enrolled1 locationNCT07238816
Recruiting
Phase 1
Clinical Trial of the Adsorbed Acellular Pertussis (Tricomponent) DTaP-Haemophilus Influenzae Type b (Conjugate)-ACYW135 Group Meningococcal (Conjugate) Combined Vaccine
Diphtheria, Tetanus and Acellular PertussisEpidemic MeningitisHaemophilus Influenzae Type B Infection
CanSino Biologics Inc.260 enrolled1 locationNCT07203755
Recruiting
Phase 1Phase 2
Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies
Acute Myeloid LeukemiaNon-Hodgkin LymphomaMultiple Myeloma+3 more
CellCentric Ltd.250 enrolled39 locationsNCT04068597
Recruiting
Phase 1Phase 2
To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of KN060 in ESRD Dialysis Patients
End-Stage Renal Disease Requiring Haemodialysis
Suzhou Alphamab Co., Ltd.12 enrolled1 locationNCT07201467
Recruiting
Phase 1Phase 2
Oral Deucrictibant for Prophylactic and Acute Treatment in Hereditary Angioedema Patients
Hereditary Angioedema (HAE)AngioedemaBradykinin-mediated Angioedema+1 more
Institute for Asthma and Allergy10 enrolled1 locationNCT07046806
Recruiting
Phase 1Phase 2
Neonatal Hypoxic Ischemic Encephalopathy : Safety and Feasibility Study of a Curative Treatment With Autologous Cord Blood Stem Cells
neonatal hypoxic ischaemic encephalopathy
Assistance Publique Hopitaux De Marseille20 enrolled1 locationNCT02881970
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma
NeoplasmsMultiple MyelomaParaproteinemias+5 more
Hellenic Society of Hematology36 enrolled2 locationsNCT05573802
Completed
Phase 1
An open-label, multiple dose study to compare the single-dose and steady-state pharmacokinetics of a 40 mg PHA-022121 extended-release (XR) tablet administered once daily between healthy Japanese, Chinese, and Caucasian volunteers.
Hereditary Angioedema (HAE)
Pharvaris Netherlands B.V.36 enrolled1 locationACTRN12623000736640
Recruiting
Phase 1
Phase I trial of multi-virus-specific T cells for paediatric haploidentical -stem cell transplant recipients
Haplo-identical haematopoietic stem cell transplantation
QIMR Berghofer Medical Research Institute20 enrolled1 locationACTRN12620000141943
Completed
Phase 1
A randomised, double-blind, single-dose study to evaluate the pharmacokinetic, safety, tolerability, immunogenicity and pharmacodynamic profile of ISU305 compared to Soliris® (Eculizumab) in Healthy Male Volunteers
Atypical haemolytic uraemic syndrome (aHUS)Paroxysmal nocturnal haemoglobinuria (PNH)
ISU Abxis148 enrolled2 locationsACTRN12619000694112
Withdrawn
Phase 1
A phase I study investigating the mean circulation time, biodistribution and safety of an infusion of cultured red cells (CRC) in patients with myelodysplastic syndrome (MDS) or patients in remission from haematologic malignancy
haematologic malignancy in remission and not on active treatmentvery-low or low risk myelodysplastic syndrome
Cell Therapies Pty Ltd10 enrolled2 locationsACTRN12618000661279
Completed
Phase 1
Trial of Amnion Cell Therapy for Ischaemic Stroke (I-ACT)
Ischaemic Stroke
Prof Thanh Phan8 enrolled1 locationACTRN12618000076279
Recruiting
Phase 1
5 year study of 6 children each year with vascular anomalies who have severe complications failing to respond to the usual treatments will be offered a new use of an old medication- sirolimus
PIKC3A related overgrowth syndrome (PROS)Vascular tumours (tufted angiomas and kaposiform haemangioendotheliomas)Complex lymphatic malformations+2 more
Sydney Children's Hospital, Randwick30 enrolled1 locationACTRN12616000943448