Harm Reduction Clinical Trials

8 recruitingLast updated: June 18, 2026

There are 8 actively recruiting harm reduction clinical trials across 2 countries. Studies span Not Applicable, Phase 3, Phase 4. Top locations include Boston, Massachusetts, United States, Chicago, Illinois, United States, Denver, Colorado, United States. Updated daily from ClinicalTrials.gov.


Harm Reduction Trials at a Glance

8 actively recruiting trials for harm reduction are listed on ClinicalTrialsFinder across 6 cities in 2 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Boston, Chicago, and Denver. Lead sponsors running harm reduction studies include Massachusetts General Hospital, NYU Langone Health, and Abramson Cancer Center at Penn Medicine.

Browse harm reduction trials by phase

Treatments under study

About Harm Reduction Clinical Trials

Looking for clinical trials for Harm Reduction? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Harm Reduction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Harm Reduction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 18 of 8 trials

Recruiting
Phase 4

Vending Machine Naloxone Distribution for Your Community (VENDY)

Harm ReductionOpioid OverdoseNaloxone
University of Colorado, Denver4,000 enrolled3 locationsNCT06429436
Recruiting
Not Applicable

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

E-cigarette useTobacco UseHarm Reduction+1 more
Abramson Cancer Center at Penn Medicine200 enrolled1 locationNCT06372899
Recruiting
Not Applicable

Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention

Health PromotionOpioid-use DisorderHarm Reduction
University of Pennsylvania390 enrolled3 locationsNCT06843213
Recruiting
Not Applicable

Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions

People Who Use Opioids/People With Opioid Use Disorder (OUD)Opioid Overdose PreventionReduction of Substance Use-related Stigma+2 more
University of Illinois at Chicago600 enrolled1 locationNCT06823453
Recruiting
Not Applicable

A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students

Substance UseAdolescent BehaviorHarm Reduction
Massachusetts General Hospital300 enrolled1 locationNCT06115746
Recruiting

Shelter HArm Reduction Evaluation

Harm ReductionOverdose
NYU Langone Health80 enrolled1 locationNCT07170072
Recruiting
Phase 3

Electronic Harm Reduction Treatment for Alcohol

Alcohol Use DisorderHarm ReductionHousing First (eg. Permanent Supportive Housing)
University of Washington160 enrolled1 locationNCT06702007
Recruiting
Not Applicable

Our Healthbox - Evaluating Interactive Dispensing Systems for Low-Barrier Access to HIV Testing and Harm Reduction.

HIVHIV Self-testingHarm Reduction+2 more
Unity Health Toronto5,000 enrolled1 locationNCT05516069