Heart Clinical Trials in Durham, North Carolina
46 recruitingDurham, North Carolina
Showing 1–20 of 46 trials
Recruiting
Phase 3
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Heart Failure and Impaired Kidney Function
AstraZeneca4,800 enrolled845 locationsNCT06307652
Recruiting
Phase 3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
ObesityHeart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection Fraction
Amgen5,056 enrolled596 locationsNCT07037459
Recruiting
Phase 1
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Heart
Vasa Therapeutics42 enrolled21 locationsNCT07219511
Recruiting
Phase 3
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Heart Failure
AstraZeneca11,300 enrolled928 locationsNCT06677060
Recruiting
Not Applicable
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Heart FailureHeart Failure, DiastolicCardiorenal Syndrome+5 more
Procyrion320 enrolled48 locationsNCT05677100
Recruiting
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Heart FailurePainInsomnia+22 more
Duke University5,000 enrolled51 locationsNCT04278404
Recruiting
Not Applicable
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
Heart FailureCardiovascular DiseasesHeart Diseases
BrioHealth Solutions, Inc.780 enrolled37 locationsNCT06310031
Recruiting
Phase 3
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
CardiomyopathiesAmyloidosisHeart Diseases+3 more
Eidos Therapeutics, a BridgeBio company582 enrolled98 locationsNCT06563895
Recruiting
Not Applicable
XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)
Heart FailureHeart TransplantTransplant; Failure, Heart
XVIVO Perfusion60 enrolled14 locationsNCT06895070
Recruiting
Phase 2
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Heart Failure
Novo Nordisk A/S200 enrolled109 locationsNCT06979362
Recruiting
Phase 3
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Heart FailureHeart Failure With Reduced Ejection Fraction
Cytokinetics1,800 enrolled183 locationsNCT06736574
Recruiting
Phase 2
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
Heart FailureCardiomyopathiesCardiogenic Shock+1 more
Stanford University50 enrolled5 locationsNCT06080074
Recruiting
Not Applicable
Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)
Heart FailureGroup 2 Pulmonary Hypertension
Gradient Denervation Technologies50 enrolled8 locationsNCT06052072
Recruiting
Phase 2
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Heart Failure
Bristol-Myers Squibb208 enrolled117 locationsNCT06122779
Recruiting
Not Applicable
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers
Pulmonary Embolism (Diagnosis)Diagnostic ImagingImplementation Science+7 more
Duke University75 enrolled1 locationNCT07159269
Recruiting
Phase 3
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
Acute Decompensated Heart Failure
Reprieve Cardiovascular, Inc400 enrolled53 locationsNCT06898515
Recruiting
Phase 2
Study of JK07 in Patients With Chronic Heart Failure
Heart Failure With Reduced Ejection FractionHeart Failure With Preserved Ejection Fraction
Salubris Biotherapeutics Inc282 enrolled62 locationsNCT06369298
Recruiting
Phase 3
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
Heart Failure With Preserved Ejection Fraction
Uppsala University2,000 enrolled78 locationsNCT02901184
Recruiting
Not Applicable
BiVACOR® Total Artificial Heart Early Feasibility Study
Heart FailureBiventricular Failure
BiVACOR Inc.5 enrolled4 locationsNCT06174103
Recruiting
Phase 1
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction
Heart Failure With Preserved Ejection FractionHeart Failure, Diastolic
Sardocor Corp.10 enrolled2 locationsNCT06061549