Phase 1 HIV-1 Clinical Trials
11 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–11 of 11 trials
Recruiting
Phase 1Phase 2
Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1
HIV-1-infection
National Institute of Allergy and Infectious Diseases (NIAID)36 enrolled12 locationsNCT06071767
Recruiting
Phase 1
Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1
HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)48 enrolled17 locationsNCT06517693
Recruiting
Phase 1Phase 2
Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age
HIV-1-infection
National Institute of Allergy and Infectious Diseases (NIAID)90 enrolled12 locationsNCT05660980
Recruiting
Phase 1
Inhibiting the Anti-apoptotic Factor, BCL-2, at the Time of ART Initiation to Promote Apoptosis of HIV-infected Cells and Restrict the Seeding of the HIV Reservoir (The INITIATE Study)
HIV-1
Thomas Aagaard Rasmussen38 enrolled2 locationsNCT07481175
Recruiting
Phase 1
A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV
HIV-1-infection
BioNTech SE61 enrolled3 locationsNCT07392372
Recruiting
Phase 1
Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Newborns Exposed to HIV
HIV-1-infection
Gilead Sciences16 enrolled7 locationsNCT07055451
Recruiting
Phase 1
Study of GS-3242 in Participants With HIV-1; Substudy-05
HIV-1-infection
Gilead Sciences30 enrolled28 locationsNCT07001319
Recruiting
Phase 1
Safety Study of MucoCept-CVN
HIV-1-infection
Craig Cohen, MD, MPH12 enrolled1 locationNCT07181486
Recruiting
Phase 1Phase 2
Pomalidomide as an Immune-enhancing Agent for the Control of HIV
HIV-1-infection
University of Aarhus32 enrolled2 locationsNCT06660498
Recruiting
Phase 1
PET Imaging of Radiolabeled Anti-HIV-1 Envelope Monoclonal Antibody (VRC01)
HIV-1-infection
University of California, San Francisco30 enrolled1 locationNCT03729752
Recruiting
Phase 1Phase 2
Administration of Venetoclax to Promote Apoptosis of HIV-infected Cells and Reduce the Size of the HIV Reservoir Among People Living With HIV on ART
HIV-1-infection
University of Aarhus18 enrolled1 locationNCT05668026