Phase 1 HIV-1 Clinical Trials

7 recruitingPhase 1

What is a Phase 1 trial?

Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.

Showing 1–7 of 7 trials

Recruiting

Phase 1Phase 2

Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age

HIV-1-infection

National Institute of Allergy and Infectious Diseases (NIAID)90 enrolled12 locationsNCT05660980

Recruiting

Phase 1

Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1

HIV-1

National Institute of Allergy and Infectious Diseases (NIAID)48 enrolled17 locationsNCT06517693

Recruiting

Phase 1

Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Newborns Exposed to HIV

HIV-1-infection

Gilead Sciences16 enrolled7 locationsNCT07055451

Recruiting

Phase 1

Study of GS-3242 in Participants With HIV-1; Substudy-05

HIV-1-infection

Gilead Sciences30 enrolled28 locationsNCT07001319

Recruiting

Phase 1Phase 2

Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1

HIV-1-infection

National Institute of Allergy and Infectious Diseases (NIAID)36 enrolled12 locationsNCT06071767

Recruiting

Phase 1

PET Imaging of Radiolabeled Anti-HIV-1 Envelope Monoclonal Antibody (VRC01)

HIV-1-infection

University of California, San Francisco30 enrolled1 locationNCT03729752

Recruiting

Phase 1Phase 2

Administration of Venetoclax to Promote Apoptosis of HIV-infected Cells and Reduce the Size of the HIV Reservoir Among People Living With HIV on ART

HIV-1-infection

University of Aarhus18 enrolled1 locationNCT05668026