Phase 1 Infections Clinical Trials
40 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 40 trials
Recruiting
Phase 1Phase 2
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
NeutropeniaInfectionsWarts+2 more
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled1 locationNCT00967785
Recruiting
Phase 1Phase 2
A Study on the Safety and Immune Response of a Urinary Tract Infection (UTI) Vaccine in Adults 18-64 Years of Age and Clinical Efficacy in Females 18-64 Years of Age
Urinary Tract Infections
GlaxoSmithKline448 enrolled8 locationsNCT06702449
Recruiting
Phase 1
First Time in Human Study of Long Acting VH4524184 Formulations
HIV Infections
ViiV Healthcare268 enrolled3 locationsNCT06310551
Recruiting
Phase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)40 enrolled7 locationsNCT06665646
Recruiting
Phase 1Phase 2
CAR-T Cells for HIV Infection
HIV Infections
Steven Deeks18 enrolled2 locationsNCT04648046
Recruiting
Phase 1Phase 2
FMT for the Decolonization of Carbapenem-resistant Enterobacteriaceae
Enterobacteriaceae InfectionsMulti-antibiotic Resistance
Fondazione Policlinico Universitario Agostino Gemelli IRCCS52 enrolled1 locationNCT04759001
Recruiting
Phase 1
Safety and Immunogenicity Study of Three mRNAs Encoding HIV Immunogens in Adult Participants Without HIV and in Overall Good Health in South Africa.
HIV Infections
International AIDS Vaccine Initiative96 enrolled6 locationsNCT06694753
Recruiting
Phase 1
[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects
Bacterial Infections
University of Pennsylvania20 enrolled1 locationNCT04263792
Recruiting
Phase 1
Single-Dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Pevifoscorvir Sodium (ALG-000184) in Subjects With Moderate Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function
Chronic Hepaititis B Infections
Aligos Therapeutics16 enrolled1 locationNCT07342868
Recruiting
Phase 1Phase 2
A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection
Cystic Fibrosis LungRespiratory Infections, Recurrent, Chronic
Respirion Pharmaceuticals Pty Ltd72 enrolled22 locationsNCT06016088
Recruiting
Phase 1
A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV
HIV Infections
ViiV Healthcare100 enrolled41 locationsNCT07053384
Recruiting
Phase 1
A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants
HIV Infections
ViiV Healthcare214 enrolled3 locationsNCT05418868
Recruiting
Phase 1Phase 2
A Study of BLB-201 RSV Vaccine in Infants and Children
Respiratory Syncytial Virus Infections
Blue Lake Biotechnology Inc.137 enrolled11 locationsNCT05655182
Recruiting
Phase 1
A Study to Investigate Safety and Pharmacokinetics of Intravenous Cefiderocol/Xeruborbactam in Participants With Renal Impairment
Bacterial Infections
Qpex Biopharma, Inc.40 enrolled2 locationsNCT07104162
Recruiting
Phase 1
MTC Versus FMT in for RCDI
Clostridiodies Difficile Infections
Icahn School of Medicine at Mount Sinai60 enrolled1 locationNCT05911997
Recruiting
Phase 1
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of VH4011499 Compared to Placebo in Adults Without HIV
HIV Infections
ViiV Healthcare168 enrolled2 locationsNCT06724640
Recruiting
Phase 1Phase 2
Phase 1b/2a Randomized Double-blind Study to Investigate Safety Tolerability PK PD Preliminary Efficacy of Oral Administration of SNIPR001 in Patients With Hematologic Malignancy Scheduled for Allogeneic Hematopoietic Stem-Cell Transplant Receiving FQ Prophylaxis & Harboring FQR Ecoli Pre-Transplant
E Coli InfectionsAllogenic Transplant Patients
SNIPR Biome Aps.24 enrolled8 locationsNCT06938867
Recruiting
Phase 1
Phase I Study of Single/Multiple Ascending Doses of JKN2501 for Injection in Chinese Healthy Volunteers
Bacterial InfectionsRespiratory Tract InfectionsUrinary Tract Infections+1 more
Joincare Pharmaceutical Group Industry Co., Ltd66 enrolled1 locationNCT07207291
Recruiting
Phase 1
Assess the Plasma, Epithelial Lining, and Alveolar Macrophage Concentrations of Intravenous Meropenem-Pralubactam (Meropenem/FL058) in China Healthy Adult Participants
Infections
Qilu Pharmaceutical Co., Ltd.16 enrolled1 locationNCT07124468
Recruiting
Phase 1
RV630 - Approach to Control HIV With Immune Enhancement and Vaccination (ACHIEV
HIV InfectionsARTAcute HIV Infection+1 more
Henry M. Jackson Foundation for the Advancement of Military Medicine48 enrolled1 locationNCT06484335