Phase 1 Lateral Clinical Trials
35 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 35 trials
Recruiting
Phase 1Phase 2
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
Amyotrophic Lateral Sclerosis(ALS)Mutation in the Superoxide Dismutase-1 (SOD1) Gene
Regeneron Pharmaceuticals54 enrolled20 locationsNCT06351592
Recruiting
Phase 1
A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Eli Lilly and Company32 enrolled10 locationsNCT07571174
Recruiting
Phase 1
A Master Protocol (OLMP): A Study of LY4256984 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis
Eli Lilly and Company32 enrolled10 locationsNCT07571200
Recruiting
Phase 1Phase 2
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Total Knee AnthroplastyOsteoarthritis PrimaryBilateral Knee Osteoarthritis+1 more
Unity Health Toronto60 enrolled1 locationNCT06809998
Recruiting
Phase 1Phase 2
Intestinal Microbiome Transplant in ALS
Amyotrophic Lateral Sclerosis(ALS)
Duke University20 enrolled1 locationNCT07017946
Recruiting
Phase 1
A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis
Insmed Gene Therapy LLC23 enrolled5 locationsNCT07290062
Recruiting
Phase 1
Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males
Inguinal Hernia BilateralInguinal Hernia UnilateralInguinal Hernia Without Obstruction or Gangrene+1 more
Northwestern University30 enrolled1 locationNCT07604272
Recruiting
Phase 1Phase 2
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Amyotrophic Lateral Sclerosis
Vector Y Therapeutics12 enrolled11 locationsNCT07287397
Recruiting
Phase 1Phase 2
A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis(ALS)
Nura Bio80 enrolled8 locationsNCT07369076
Recruiting
Phase 1Phase 2
A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Leal Therapeutics, Inc56 enrolled5 locationsNCT07660614
Recruiting
Phase 1Phase 2
TP04HN106 in the Treatment of Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Talengen Institute of Life Sciences, Shenzhen, P.R. China.60 enrolled1 locationNCT06726577
Recruiting
Phase 1
Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes
osseointegrationAmputationTranstibial Amputation - Unilateral+1 more
University of Colorado, Denver60 enrolled1 locationNCT07263945
Not Yet Recruiting
Phase 1
A study to assess safety, tolerability and pharmacokinetics of RTX-010/101/111 for participants with C9orf72-mediated Amyotrophic Lateral Sclerosis (ALS). Part 1C adults with C9orf72-mediated ALS only.
C9orf72-mediated Amyotrophic Lateral Sclerosis (ALS)
Repeat Therapeutics Pty Ltd16 enrolled1 locationACTRN12626000385347
Recruiting
Phase 1
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
ALS (Amyotrophic Lateral Sclerosis)
Eli Lilly and Company32 enrolled12 locationsNCT07100119
Recruiting
Phase 1Phase 2
Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss
Sensorineural Hearing Loss, Bilateral
Akouos, Inc.22 enrolled9 locationsNCT05821959
Recruiting
Phase 1
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
PRG Science & Technology Co., Ltd.48 enrolled1 locationNCT07221240
Recruiting
Phase 1Phase 2
Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis
Biogipuzkoa Health Research Institute90 enrolled1 locationNCT07414212
Recruiting
Phase 1
Safety and Tolerability Study of CTx1000 In Participants With Amyotrophic Lateral Sclerosis
ALS (Amyotrophic Lateral Sclerosis)
Celosia Therapeutics Pty Ltd15 enrolled1 locationNCT07401121
Recruiting
Phase 1Phase 2
Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral Limbal Stem Cell Deficiency
Total Bilateral Limbal Cell Deficiency
Hospices Civils de Lyon40 enrolled1 locationNCT03949881
Recruiting
Phase 1
The Safety, Tolerability and Preliminary Efficacy of Derived Motor Neuron Progenitor Cells (XS228CN) in Subjects With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis(ALS)
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT07118319