Phase 2 LET Clinical Trials
45 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 45 trials
Recruiting
Phase 2Phase 3
A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Bristol-Myers Squibb590 enrolled277 locationsNCT07063745
Recruiting
Phase 1Phase 2
Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients
Lung CancerNSCLCThoracic Cancer+5 more
Tango Therapeutics, Inc.183 enrolled18 locationsNCT06922591
Recruiting
Phase 1Phase 2
NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
AngiosarcomaLiposarcomaAdipocytic Neoplasm+6 more
St. Jude Children's Research Hospital139 enrolled6 locationsNCT06239272
Recruiting
Phase 1Phase 2
A First-in-human Study to Learn How Safe BAY 3713372 is and How it Works in Participants With MTAP-deleted Solid Tumors
MTAP-deleted Solid Tumors
Bayer370 enrolled60 locationsNCT06914128
Recruiting
Phase 2
A Phase II Study Evaluating BMS-986504 in MTAP-deleted Pancreatic Cancer
Phase 2 StudyBMS-986504MTAP-deleted Pancreatic Cancer
M.D. Anderson Cancer Center60 enrolled1 locationNCT07283705
Recruiting
Phase 2
Low-Dose Sirolimus to Increase Hematopoietic Function in Patients With RUNX1 Familial Platelet Disorder
Familial Platelet DisorderHematopoietic
M.D. Anderson Cancer Center6 enrolled1 locationNCT06261060
Recruiting
Phase 1Phase 2
S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP
MTAP-deleted Solid Tumors
Servier Bio-Innovation LLC342 enrolled35 locationsNCT06188702
Recruiting
Phase 2
A Phase 2 Study of Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
MTAP-deleted NSCLC
Amgen200 enrolled91 locationsNCT06593522
Recruiting
Phase 2
Hippocampus-Protective Radiotherapy Combined With Osimertinib for Symptomatic Brain Metastases in EGFR-Mutated Lung Cancer
Naive Advanced Non-small Cell Lung Cancer With EGFR-sensitive Mutations (EGFR Exon 19 Deletion and Exon 21 L858R Mutation) and Symptomatic Brain Metastases
Tianjin Medical University Cancer Institute and Hospital74 enrolled1 locationNCT07505173
Recruiting
Phase 2
Platelet Rich Plasma Injections In Young And Old Human Subjects
OsteoarthritisMusculoskeletal DisordersArticular Cartilage
University of California, San Francisco60 enrolled1 locationNCT06451120
Recruiting
Phase 1Phase 2
SNB-101 for Treatment of Extensive Stage Small Cell Lung Cancer
Patient is Not Suitable for Complete Surgical Resection With a Cytologically or Histologically Confirmed Small Cell Lung Cancer(SCLC)
SN BioScience55 enrolled1 locationNCT07391813
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Phase 2
BPC 157 for Acute Hamstring Muscle Strain Repair
Hamstring Muscle StrainSkeletal Muscle Injury
Hudson Biotech120 enrolled1 locationNCT07437547
Recruiting
Phase 2
Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders
Dyskeratosis CongenitaFanconi AnemiaMyelodysplastic Syndromes+5 more
Masonic Cancer Center, University of Minnesota48 enrolled1 locationNCT03579875
Recruiting
Phase 2
Neoadjuvant Immunochemotherapy and Chemoradiotherapy Followed by Surgery for Advanced Esophageal Squamous Cell Carcinoma
ESCCPathological Complete ResponseTotal Neoadjuvant Treatment
National Taiwan University Hospital50 enrolled1 locationNCT06764355
Recruiting
Phase 2
Delayed Cold-Stored Platelets -PLTS-1
BleedingCardiac SurgeryCardiopulmonary Bypass+1 more
University Health Network, Toronto150 enrolled2 locationsNCT06147531
Recruiting
Phase 1Phase 2
Phase I/II Study of Engineered T Cell Receptor-Modified NK Cells Targeting PRAME in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Myeloid Malignancies
Myeloid MalignanciesLymphodepleting Chemotherapy
M.D. Anderson Cancer Center44 enrolled1 locationNCT06383572
Recruiting
Phase 2
Using ctDNA to Determine Therapies for Lung Cancer
Non-small Cell Lung CancerCirculating Tumor DNAComplete Surgical Resection
University Health Network, Toronto66 enrolled1 locationNCT04966663
Not Yet Recruiting
Phase 2
Clinical Trial to investigate the feasibility, safety, and tolerability of BMS-986504 in patients with recurrent MTAP-deleted Glioblastoma
Recurrent MTAP-deleted Glioblastoma
Peter MacCallum Cancer Centre10 enrolled1 locationACTRN12625001238460
Recruiting
Phase 1Phase 2
Study of CM313(SC) Injection in Subjects With Platelet Transfusion Refractoriness
Platelet Transfusion Refractoriness
Keymed Biosciences Co.Ltd110 enrolled1 locationNCT06792019