Phase 1 Locally Advanced or Metastatic Solid Tumors Clinical Trials
19 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–19 of 19 trials
Recruiting
Phase 1
A First-in-human Phase I Study to Evaluate EMB-15 in Patients With Locally Advanced or Metastatic Solid Tumors.
Locally Advanced or Metastatic Solid Tumors
Shanghai EpimAb Biotherapeutics Co., Ltd.50 enrolled1 locationNCT07607054
Recruiting
Phase 1
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
Colorectal, CancerEsophageal CancerGastric Cancer+9 more
Genentech, Inc.450 enrolled41 locationsNCT05581004
Recruiting
Phase 1
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
Colorectal, CancerPancreatic CancerGastric Cancer+1 more
ArriVent BioPharma, Inc.405 enrolled20 locationsNCT07066657
Recruiting
Phase 1Phase 2
BC3195 in Combination With Pembrolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Biocity Biopharmaceutics Co., Ltd.111 enrolled1 locationNCT07469774
Recruiting
Phase 1
GenSci145 as Monotherapy or in Combination Therapy, in Participants With PIK3CA-mutated, Locally Advanced or Metastatic Solid Tumors.
Locally Advanced or Metastatic Solid Tumors With PIK3CA-mutated
Changchun GeneScience Pharmaceutical Co., Ltd.186 enrolled1 locationNCT07407504
Recruiting
Phase 1
A Study to Investigate ANS014004 in Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Avistone Biotechnology Co., Ltd.63 enrolled15 locationsNCT06307795
Recruiting
Phase 1
Study of XB010 in Subjects With Solid Tumors
Hormone Receptor-Positive Breast CancerLocally Advanced or Metastatic Solid TumorsTriple Negative Breast Cancer(TNBC)+3 more
Exelixis396 enrolled19 locationsNCT06545331
Recruiting
Phase 1
A Study to Investigate ANS03 in Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors Harboring a ROS1 or NTRK Alteration
Avistone Biotechnology Co., Ltd.96 enrolled5 locationsNCT06716138
Recruiting
Phase 1Phase 2
IBI3014 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
Unresectable Locally Advanced or Metastatic Solid Tumors
Innovent Biologics (Suzhou) Co. Ltd.250 enrolled3 locationsNCT06974812
Recruiting
Phase 1
A Study of BL-M05D1 in Patients With Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Sichuan Baili Pharmaceutical Co., Ltd.30 enrolled1 locationNCT06349811
Recruiting
Phase 1
A Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of ATG 037 Monotherapy and Combination Therapy With Pembrolizumab in Patients With Advanced Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Antengene Therapeutics Limited98 enrolled7 locationsNCT05205109
Recruiting
Phase 1Phase 2
A Study to Investigate the Safety, Pharmacokinetics, and Clinical Activity of AP203 in Patients with Locally Advanced or Metastatic Solid Tumors, and Expansion to Selected Malignancies
Head and Neck Squamous Cell Carcinoma (HNSCC)Non-small Cell Lung Cancer (NSCLC)Locally Advanced or Metastatic Solid Tumors+1 more
AP Biosciences Inc.168 enrolled1 locationNCT05473156
Recruiting
Phase 1Phase 2
PTT-936 Alone or in Combination in Patients With Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Pyrotech Therapeutics, Inc.68 enrolled3 locationsNCT06244992
Recruiting
Phase 1Phase 2
Clinical Trial to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DA-4505 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Dong-A ST Co., Ltd.125 enrolled2 locationsNCT06293651
Recruiting
Phase 1
Study of IBI3005 in Subjects With Unresectable, Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Solid TumorsUnresectable
Innovent Biologics (Suzhou) Co. Ltd.198 enrolled1 locationNCT06418061
Recruiting
Phase 1
A Study of TYK-00540 in Adult Patients With Solid Tumors
Locally Advanced or Metastatic Solid Tumors
TYK Medicines, Inc156 enrolled1 locationNCT06246071
Recruiting
Phase 1Phase 2
IFNα Expressing Mesenchymal Stromal Cells for Locally Advanced/Metastatic Solid Tumors
Locally Advanced or Metastatic Solid Tumors
Chinese PLA General Hospital40 enrolled1 locationNCT05699811
Recruiting
Phase 1
Phase I study to evaluate Safety and Tolerability of RX108-A Tablets in Patients with advanced Cancer
Locally Advanced or Metastatic Solid Tumors
NeuPharma Pty Ltd20 enrolled2 locationsACTRN12623000307606
Recruiting
Phase 1Phase 2
A Study of XZP-5955 Tablets in Patients With NTRK or ROS1 Fusion Positive Locally Advanced or Metastatic Solid Tumors
Locally Advanced or Metastatic Non-small Cell Lung CancerLocally Advanced or Metastatic Solid Tumors
Xuanzhu Biopharmaceutical Co., Ltd.360 enrolled1 locationNCT04996121