Phase 1 Lung Disease Clinical Trials
13 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–13 of 13 trials
Recruiting
Phase 1Phase 2
Feasibility of Semaglutide in Advanced Lung Disease
ObesityChronic Obstructive Pulmonary DiseaseInterstitial Lung Disease+2 more
University of Pennsylvania8 enrolled1 locationNCT05746039
Recruiting
Phase 1Phase 2
A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors
Thoracic Neoplasms, Lung Diseases, Small Cell Lung Carcinoma
MediLink Therapeutics (Suzhou) Co., Ltd.118 enrolled4 locationsNCT07407933
Recruiting
Phase 1
Investigation of Small Mobile Stem Cells (SMS Cells) in Participants With Chronic Obstructive Pulmonary Disease (COPD).
Chronic Obstructive Lung Disease
SMSbiotech18 enrolled2 locationsNCT06986070
Recruiting
Phase 1
A Study of the Pharmacokinetics and Safety of Single-dose Inhaled RJ026 in Healthy Volunteers and Patients With Interstitial Lung Disease
Healthy VolunteersInterstitial Lung Disease (ILD)
Ruijin Hospital84 enrolled1 locationNCT06992661
Recruiting
Phase 1
Nebulized Human Amniotic Fluid in Patients With Interstitial Lung Disease
Lung Diseases, Interstitial
Maule Stem Cell Research Institute, Inc.50 enrolled1 locationNCT07372989
Recruiting
Phase 1
Nebulized MSC-Exos for Anti-MDA5+ RP-ILD: Safety and Efficacy Trial
Anti-MDA5 Positive Dermatomyositis-Associated RP-ILDRapidly Progressive Interstitial Lung Disease
Li Shiyue10 enrolled1 locationNCT06919380
Recruiting
Phase 1
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
AsthmaCOPDCystic Fibrosis+4 more
Mario Castro, MD, MPH260 enrolled1 locationNCT04624490
Recruiting
Phase 1Phase 2
ADSCs Therapy in Patients With CTD-ILD
Interstitial Lung DiseaseConnective Tissue Diseases
China Medical University Hospital16 enrolled1 locationNCT06574581
Recruiting
Phase 1
Safety of Endobronchial Mesenchymal Stromal Cells in the Treatment of Chronic Lung Allograft Dysfunction
Chronic Lung DiseaseLung Transplant Rejection
Instituto De Investigación Sanitaria Puerta De Hierro-Segovia De Arana12 enrolled1 locationNCT06514378
Active
Phase 1
A 3-part study consisting of a randomised, double-blind, placebo-controlled, single ascending dose study in healthy participants, followed by an open-labelled single dose LPS-challenge study in healthy participants and an open-labelled multiple dose study in COPD patients to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of EMP-012 for Injection Administered Subcutaneously.
Chronic Lung Disease
Empirico Inc.40 enrolled2 locationsACTRN12624000650594
Completed
Phase 1
A Phase 1 Study of AP02 (Nintedanib Solution for Inhalation) Delivered via the PARI eFlow® Nebulizer System in Healthy Volunteers and Patients with Idiopathic Pulmonary Fibrosis or Progressive Fibrosing Interstitial Lung Disease
Progressive, Fibrosing Interstitial Lung DiseasesIdiopathic Pulmonary Fibrosis
Avalyn Pharma Pty Ltd38 enrolled1 locationACTRN12620001141932
Completed
Phase 1
Evaluation of the Safety, Tolerability, Immunogenicity, Pharmacokinetics and Pharmacodynamics of Intravenous ATYR1923 in Healthy Volunteers.
Interstitial Lung Disease
INCResearch Australia Pty Ltd36 enrolled1 locationACTRN12617001446358
Completed
Phase 1
Inhalation of Leukotriene B4 (LTB4) in patients suffering from Bronchiectasis
BronchiectasisChronic Suppurative Lung Disease
LTB4 Sweden AB30 enrolled1 locationACTRN12614001199606