RecruitingPhase 1Phase 2NCT05746039

Feasibility of Semaglutide in Advanced Lung Disease

Feasibility of Semaglutide Therapy for Weight Loss in Advanced Lung Disease: A Pilot Study

Sponsor

University of Pennsylvania

Enrollment

8 participants

Start Date

Jan 29, 2024

Study Type

INTERVENTIONAL

Conditions

Obesity Chronic Obstructive Pulmonary Disease Interstitial Lung Disease Pulmonary Hypertension Sarcoidosis, Pulmonary

Summary

The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide therapy? 2. Are we able to titrate semaglutide therapy to a target weight? Participants will be asked to perform pulmonary function, physical function and body composition testing, as well as a blood draw before and after 12-weeks of semaglutide therapy. While on therapy, subjects will be surveyed regarding any adverse events or side effects.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether semaglutide (a weight-loss and diabetes drug, brand names Ozempic/Wegovy) is safe and feasible for people with advanced lung disease who are also significantly overweight. Researchers hope that weight loss may ease breathing and reduce disease burden. **You may be eligible if...** - You have been diagnosed with interstitial lung disease, sarcoidosis, COPD, or pulmonary hypertension - You are over 18 years old with a BMI over 30 - You need supplemental oxygen when active - Your treatment regimen has been stable for at least 90 days **You may NOT be eligible if...** - You have diabetes - You are pregnant or breastfeeding - You have a history of gastroparesis (delayed stomach emptying), scleroderma, or pancreatitis - You have had recent unexplained weight loss - You have ongoing stomach or digestive complaints - You have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 - You have a pacemaker or defibrillator - You have had suicidal thoughts or attempts in the past 90 days Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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