Phase 2 Lupus Nephritis Clinical Trials
23 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 23 trials
Recruiting
Phase 2
Obe-cel in Severe, Refractory Systemic Lupus Erythematosus With Active Lupus Nephritis
Lupus Nephritis
Autolus Limited35 enrolled26 locationsNCT07053800
Recruiting
Phase 2
A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)
Lupus Erythematosus, SystemicLupus Nephritis
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company89 enrolled93 locationsNCT07015983
Recruiting
Phase 2
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
Lupus Nephritis
Novartis Pharmaceuticals240 enrolled103 locationsNCT05268289
Recruiting
Phase 1Phase 2
Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders
Systemic Lupus ErythematosusLupusAutoimmune Disorders+2 more
M.D. Anderson Cancer Center47 enrolled2 locationsNCT06434363
Recruiting
Phase 1Phase 2
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
Systemic Lupus ErythematosusLupus Nephritis
Cabaletta Bio28 enrolled23 locationsNCT06121297
Recruiting
Phase 2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
Lupus Nephritis
Hoffmann-La Roche40 enrolled42 locationsNCT05039619
Recruiting
Phase 2
The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study
Lupus Nephritis
Children's Hospital Medical Center, Cincinnati105 enrolled19 locationsNCT05538208
Recruiting
Phase 2
The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment
Systemic Lupus Erythematosus (SLE)Lupus Nephritis (LN)
Nanjing University School of Medicine50 enrolled1 locationNCT07340463
Recruiting
Phase 1Phase 2
Anti-CD19 Chimeric Antigen Receptor T Cells for Refractory Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE)Lupus Nephritis (LN)
Beijing GoBroad Hospital18 enrolled1 locationNCT06585514
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
Lupus NephritisPrimary Membranous Nephropathy
Nkarta, Inc.96 enrolled16 locationsNCT06557265
Recruiting
Phase 1Phase 2
Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.
Refractory Lupus NephritisSystemic SclerosisPrimary Sjogren's Syndrome Combined With Pulmonary Hypertension
Beijing GoBroad Hospital45 enrolled1 locationNCT06947473
Recruiting
Phase 1Phase 2
CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH
Refractory Lupus NephritisSystemic SclerosisPrimary Sjogren's Syndrome Combined With Pulmonary Hypertension
Beijing GoBroad Hospital45 enrolled1 locationNCT06947460
Recruiting
Phase 2
A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)
Lupus Erythematosus, SystemicLupus Nephritis
Novartis Pharmaceuticals179 enrolled93 locationsNCT06581198
Recruiting
Phase 2
Study to Assess Efficacy and Safety of HSK39297 Tablets in Patients With LN
Lupus Nephritis (LN)
Haisco Pharmaceutical Group Co., Ltd.105 enrolled1 locationNCT07363460
Recruiting
Phase 1Phase 2
Phase IIa Study for IPG11406 in Patients With Lupus Nephritis
Lupus Nephritis
Nanjing Immunophage Biotech Co., Ltd36 enrolled17 locationsNCT06717815
Recruiting
Phase 2
VIBRANT: VIB4920 for Active Lupus Nephritis
Lupus Nephritis
National Institute of Allergy and Infectious Diseases (NIAID)74 enrolled17 locationsNCT05201469
Recruiting
Phase 2
A Phase II Clinical Study on the Efficacy and Safety of SHR-2173 Injection in the Treatment of Patients With Active Lupus Nephritis
Active Lupus Nephritis
Guangdong Hengrui Pharmaceutical Co., Ltd51 enrolled1 locationNCT07229742
Recruiting
Phase 2
A Study to Evaluate the Efficacy, Safety, and Tolerability of Human Sialidase Fusion Protein (HLX79) in Combination With Rituximab Injection Versus Placebo in Patients With Active Glomerulonephritis
Lupus Nephritis (LN)Membranous Nephropathy
Shanghai Henlius Biotech24 enrolled17 locationsNCT07038382
Recruiting
Phase 2
Treatment of Lupus Nephritis With Allogeneic Mesenchymal Stem Cells
Lupus ErythematosusLupus Nephritis
Red de Terapia Celular20 enrolled1 locationNCT03673748
Recruiting
Phase 2
SGLT2 Inhibitor in Lupus Nephritis Patients With Chronic Kidney Disease
Chronic Kidney DiseasesLupus Nephritis
The University of Hong Kong150 enrolled1 locationNCT06155604