Phase 2 Major Depressive Disorder Clinical Trials
63 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 63 trials
Recruiting
Phase 2
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Major Depressive Disorder (MDD)
Draig Therapeutics Ltd300 enrolled40 locationsNCT07300969
Recruiting
Phase 2
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Major Depressive DisorderAnxiety Disorders
National Institute of Mental Health (NIMH)3,500 enrolled1 locationNCT00018057
Recruiting
Phase 1Phase 2
Personalized Ultrasonic Brain Stimulation for Depression (R61)
Depression - Major Depressive DisorderMajor Depressive EpisodeTreatment-Resistant Major Depressive Disorder
Brian Mickey30 enrolled1 locationNCT06902298
Recruiting
Phase 2
Mindfulness Engaged Neurostimulation for Depression (MEND II)
DepressionDepressive DisorderDepressive Symptoms+2 more
University of California, San Diego120 enrolled1 locationNCT07512284
Recruiting
Phase 1Phase 2
Pharmacokinetics, Safety, Tolerability and Efficacy of a Subcutaneous Long-Acting Injection of Cariprazine (Cariprazine Depot) in Subjects Eligible for Treatment With Oral Cariprazine
SchizophreniaMajor Depressive DisorderBipolar I Disorder
Mapi Pharma Ltd.24 enrolled6 locationsNCT07185815
Recruiting
Phase 2
Neutralizing Interleukin (IL)-6
Major Depressive Disorder
Icahn School of Medicine at Mount Sinai60 enrolled1 locationNCT07493317
Recruiting
Phase 1Phase 2
Neural Response to Inflammatory Challenge in Major Depressive Disorder
Major Depressive Disorder
Laureate Institute for Brain Research, Inc.180 enrolled1 locationNCT04751331
Recruiting
Phase 2
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
Major Depressive Disorder (MDD)Depressive Disorder, Treatment-Resistant
ACADIA Pharmaceuticals Inc.153 enrolled13 locationsNCT07284667
Recruiting
Phase 2
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Major Depressive Disorder
Syndeio Biosciences, Inc164 enrolled32 locationsNCT07115329
Recruiting
Phase 2
Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder
Major Depressive Disorder (MDD)
Roger McIntyre30 enrolled1 locationNCT07523048
Recruiting
Phase 2
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
Mild Neurocognitive DisorderMajor Depressive DisorderHIV
National Institute of Allergy and Infectious Diseases (NIAID)186 enrolled40 locationsNCT06705478
Recruiting
Phase 2
A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder
Major Depressive Disorder
Sirtsei Pharmaceuticals, Inc.456 enrolled50 locationsNCT06254612
Recruiting
Phase 2
A Randomized Neuroimaging Trial of Psilocybin in Depression
Depressive DisorderMajor Depressive Disorder
Sunnybrook Health Sciences Centre50 enrolled1 locationNCT06072898
Recruiting
Phase 2
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
Major Depressive Disorder (MDD)Major Depressive Disorder With Anxious Distress
Seaport Therapeutics360 enrolled45 locationsNCT07065240
Recruiting
Phase 2
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
Major Depressive Disorder
AbbVie195 enrolled31 locationsNCT07276997
Recruiting
Phase 2
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
Major Depressive Disorder (MDD)
Supernus Pharmaceuticals, Inc.230 enrolled1 locationNCT07226661
Recruiting
Phase 2
Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Major Depressive Disorder
Syndeio Biosciences, Inc164 enrolled34 locationsNCT06547489
Recruiting
Phase 2
A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression
Major Depressive Disorder (MDD)
Daniel Lindqvist12 enrolled1 locationNCT07396272
Not Yet Recruiting
Phase 2
PANDA: Psilocybin-assisted therapy for treatment of alcohol use disorder and comorbid depression
Major Depressive DisorderAlcohol Use Disorder
Eastern Health10 enrolled1 locationACTRN12626000316303
Recruiting
Phase 2
Imaging Depression in Parkinson's Disease
Major Depressive DisorderParkinson's Disease
Yale University120 enrolled1 locationNCT06402955