Phase 2 Mesothelioma Clinical Trials
40 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 40 trials
Recruiting
Phase 2
Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma
Peritoneal Malignant Mesothelioma
National Cancer Institute (NCI)66 enrolled40 locationsNCT05001880
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
Colorectal, CancerOvarian CancerLung Cancer+17 more
A2 Biotherapeutics Inc.474 enrolled12 locationsNCT06051695
Recruiting
Phase 1Phase 2
Integration of the PD-L1 Inhibitor Atezolizumab and WT1/DC Vaccination Into Platinum/Pemetrexed-based First-line Treatment for Epithelioid Malignant Pleural Mesothelioma
Malignant Pleural Mesothelioma
University Hospital, Antwerp15 enrolled3 locationsNCT05765084
Recruiting
Phase 1Phase 2
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Colorectal, CancerEsophageal CancerGastric Cancer+5 more
Perspective Therapeutics112 enrolled8 locationsNCT06710756
Recruiting
Phase 2
Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma
Pleural Biphasic MesotheliomaPleural Sarcomatoid Mesothelioma
Alliance for Clinical Trials in Oncology26 enrolled132 locationsNCT05647265
Recruiting
Phase 1Phase 2
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
Triple-Negative Breast CancerEndometrial CancerPrimary Peritoneal Carcinoma+12 more
Genmab884 enrolled66 locationsNCT05579366
Recruiting
Phase 2
A Study of Sacituzumab Govitecan in People With Mesothelioma
MesotheliomaMesotheliomas PleuralMesothelioma; Pleura
Memorial Sloan Kettering Cancer Center33 enrolled7 locationsNCT06477419
Recruiting
Phase 2
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
Sub-study 1 Cervical Cancer (Volrustomig Monotherapy)Sub-study 2 Head and Neck Squamous Cell Carcinoma (Volrustomig Monotherapy)Sub-study 3 Head and Neck Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy)+2 more
AstraZeneca257 enrolled95 locationsNCT06535607
Recruiting
Phase 2
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
Gastric CancerOvarian CancerCholangiocarcinoma+7 more
National Cancer Institute (NCI)320 enrolled1 locationNCT06503146
Recruiting
Phase 2
Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery
Malignant MesotheliomaCD30-Positive Neoplastic Cells Present
M.D. Anderson Cancer Center55 enrolled1 locationNCT03007030
Recruiting
Phase 1Phase 2
A 2-part Phase 1/2 Open-label Trial on ODM-212
Pancreatic CancerMesotheliomaNSCLC (Advanced Non-small Cell Lung Cancer)
Orion Corporation, Orion Pharma229 enrolled2 locationsNCT07563738
Recruiting
Phase 2
Agnostic Therapy in Rare Solid Tumors
Cancer of Unknown PrimarySoft Tissue SarcomaCholangiocarcinoma+38 more
Instituto do Cancer do Estado de São Paulo28 enrolled8 locationsNCT06638931
Recruiting
Phase 1Phase 2
A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
Colorectal, CancerHepatocellular CarcinomaMelanoma+15 more
7 Hills Pharma, LLC126 enrolled5 locationsNCT06362369
Recruiting
Phase 1Phase 2
Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma
Malignant Pleural Mesotheliomas
Beijing Biotech36 enrolled1 locationNCT07510815
Recruiting
Phase 1Phase 2
Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
NSCLCSolid Tumor, AdultMesothelioma
Vivace Therapeutics, Inc434 enrolled12 locationsNCT04665206
Recruiting
Phase 2
Evaluating Ivonescimab as a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and Chemotherapy
Pleural Mesotheliomas
Intergroupe Francophone de Cancerologie Thoracique38 enrolled20 locationsNCT06840834
Recruiting
Phase 1Phase 2
Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Advanced Renal Cell Carcinoma, Mesothelioma and Osteosarcoma
Advanced Renal Cell CarcinomaAdvanced MesotheliomaAdvanced Osteosarcoma
M.D. Anderson Cancer Center50 enrolled1 locationNCT05703854
Recruiting
Phase 1Phase 2
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
Esophageal CancerPancreatic CancerHead and Neck Squamous Cell Carcinoma (HNSCC)+22 more
VM Oncology, LLC242 enrolled15 locationsNCT03556228
Recruiting
Phase 2
MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI
Mesothelioma
Brigham and Women's Hospital130 enrolled1 locationNCT05730816
Recruiting
Phase 2
IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers
Peritoneal MesotheliomaAnaplastic Thyroid CarcinomasCarcinoid Tumor+3 more
Hospices Civils de Lyon154 enrolled15 locationsNCT06790706