Phase 1 Metastasis Clinical Trials
33 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 33 trials
Recruiting
Phase 1Phase 2
Exploration of the Application of Methotrexate-loaded Drug Vesicles in Intrathecal Injection for Meningeal Metastasis of Lung Cancer
Leptomeningeal Metastasis From Lung Cancer
Henan Cancer Hospital14 enrolled1 locationNCT07559097
Recruiting
Phase 1
FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3
Urinary Bladder NeoplasmsNeoplasm MetastasisUreteral Neoplasms
Eli Lilly and Company535 enrolled84 locationsNCT05614739
Recruiting
Phase 1Phase 2
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
MetastasisCastration-Resistant Prostatic Cancer
Merck Sharp & Dohme LLC360 enrolled75 locationsNCT06863272
Recruiting
Phase 1Phase 2
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Metastatic Renal Cell CarcinomaCarcinoma, Renal CellAdvanced Renal Cell Carcinoma+8 more
Pfizer224 enrolled49 locationsNCT07227415
Recruiting
Phase 1
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Breast NeoplasmsColorectal NeoplasmsProstate Neoplasm+2 more
Eli Lilly and Company421 enrolled28 locationsNCT07114601
Recruiting
Phase 1
A Phase I Study of the NovoTTF-200M and Novo TTF-200A Systems for the Treatment of Refractory Spinal Metastasis
Spinal Metastasis
M.D. Anderson Cancer Center30 enrolled1 locationNCT06906900
Recruiting
Phase 1Phase 2
A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
MelanomaAdvanced Solid TumorMetastasis+5 more
7 Hills Pharma, LLC126 enrolled5 locationsNCT06362369
Recruiting
Phase 1Phase 2
Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
Breast CancerMetastasis
Icahn School of Medicine at Mount Sinai42 enrolled3 locationsNCT05095207
Recruiting
Phase 1
Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors
Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)10 enrolled1 locationNCT07443020
Recruiting
Phase 1
Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
Advanced Solid TumorMetastatic Solid TumorSolid Tumor+4 more
Ankyra Therapeutics, Inc97 enrolled5 locationsNCT06171750
Recruiting
Phase 1Phase 2
Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases
CancerMetastatic CancerMetastasis+2 more
Baptist Health South Florida46 enrolled1 locationNCT05789589
Recruiting
Phase 1
Trial of Oligometastasis SBRT With Immediate, Simulation-Free Treatment Delivery (OLIGO-SWIFT)
Oligometastatic DiseaseOligometastasis
Case Comprehensive Cancer Center15 enrolled1 locationNCT07079098
Recruiting
Phase 1
Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC
Leptomeningeal MetastasisLung Cancer (NSCLC)
Shanghai Chest Hospital19 enrolled1 locationNCT06663306
Recruiting
Phase 1
Minimally-invasive Stabilization of Pelvic Metastases With Photodynamic Nails: A Multi-center Prospective Study of Functional Outcome
Pelvic Metastasis
M.D. Anderson Cancer Center50 enrolled1 locationNCT06083896
Recruiting
Phase 1Phase 2
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease
HER2-positive Breast CancerLeptomeningeal DiseaseLeptomeningeal Metastasis
H. Lee Moffitt Cancer Center and Research Institute39 enrolled2 locationsNCT04588545
Recruiting
Phase 1
ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer
Endometrial CancerMetastasisEndometrial Endometrioid Adenocarcinoma+5 more
UNC Lineberger Comprehensive Cancer Center58 enrolled1 locationNCT05542407
Recruiting
Phase 1
Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease
Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
David Bartlett, MD10 enrolled1 locationNCT07192900
Recruiting
Phase 1
A Prospective, Safety, and Efficacy Clinical Trial of Pressurized Intraperitoneal Aerosol Therapy for Peritoneal Metastasis of Colorectal Cancer
CRC (Colorectal Cancer)Peritoneal Metastasis
Second Affiliated Hospital, School of Medicine, Zhejiang University42 enrolled1 locationNCT07349043
Recruiting
Phase 1
Study of PAT in Patients With Solid Tumor Cancers
MetastasisSolid Tumor
Masonic Cancer Center, University of Minnesota21 enrolled1 locationNCT05338658
Recruiting
Phase 1
Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC
Head and Neck NeoplasmsNeoplasm MetastasisCarcinoma, Squamous Cell+3 more
University of Chicago36 enrolled1 locationNCT06912087