Phase 2 Metastasis Clinical Trials
41 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 41 trials
Recruiting
Phase 1Phase 2
Exploration of the Application of Methotrexate-loaded Drug Vesicles in Intrathecal Injection for Meningeal Metastasis of Lung Cancer
Leptomeningeal Metastasis From Lung Cancer
Henan Cancer Hospital14 enrolled1 locationNCT07559097
Recruiting
Phase 2
Cadonilimab With Chemoradiation for Recurrent and Oligometastatic Endometrial Carcinoma
Neoplasm MetastasisEndometrial NeoplasmsNeoplasm Recurrence, Local
Shandong Cancer Hospital and Institute30 enrolled1 locationNCT06532539
Recruiting
Phase 1Phase 2
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
MetastasisCastration-Resistant Prostatic Cancer
Merck Sharp & Dohme LLC360 enrolled75 locationsNCT06863272
Recruiting
Phase 1Phase 2
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Metastatic Renal Cell CarcinomaCarcinoma, Renal CellAdvanced Renal Cell Carcinoma+8 more
Pfizer224 enrolled49 locationsNCT07227415
Recruiting
Phase 2
Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer
Stage IV Esophageal Cancer AJCC v7Stage IV Gastric Cancer AJCC v7Gastric Adenocarcinoma+2 more
M.D. Anderson Cancer Center100 enrolled1 locationNCT03161522
Recruiting
Phase 1Phase 2
Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
Breast CancerMetastasis
Icahn School of Medicine at Mount Sinai42 enrolled3 locationsNCT05095207
Recruiting
Phase 1Phase 2
A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
MelanomaAdvanced Solid TumorMetastasis+5 more
7 Hills Pharma, LLC126 enrolled5 locationsNCT06362369
Recruiting
Phase 2Phase 3
Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
Prostate CancerMetastatic Prostate CancerOligometastasis+3 more
VA Office of Research and Development464 enrolled20 locationsNCT04787744
Recruiting
Phase 2
Hepatic Arterial Infusion of Sodium Bicarbonate (NaHCO3) Combined With NASOX Regimen and Programmed Death-1 (PD-1) Inhibitors for Pancreatic Cancer Liver Metastases
Pancreatic NeoplasmsHepatic Metastasis of Pancreatic Cancer
Ruijin Hospital50 enrolled1 locationNCT07504471
Recruiting
Phase 2
A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma
MetastasisOsteosarcoma
Memorial Sloan Kettering Cancer Center45 enrolled7 locationsNCT07477457
Recruiting
Phase 2
A Phase II Trial Evaluating Radiation Boost to Painful Spinal Metastases
Spine Metastasis
Sunnybrook Health Sciences Centre108 enrolled1 locationNCT07478289
Recruiting
Phase 2
Magnetic Resonance-guided Adaptive Stereotactic Body Radiotherapy for Hepatic Metastases
Hepatic Metastasis
University Hospital Heidelberg90 enrolled1 locationNCT05027711
Recruiting
Phase 2
Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy
Prostate CancerProstate CarcinomaProstate Neoplasm+12 more
Shehzad Basaria, M.D.60 enrolled1 locationNCT06957691
Recruiting
Phase 2
Stereotactic Radiotherapy (SBRT) of Lung Metastasis
Non-small Cell Lung CancerMetastasis From Other Cancers
University Health Network, Toronto200 enrolled1 locationNCT01803542
Recruiting
Phase 1Phase 2
Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases
CancerMetastatic CancerMetastasis+2 more
Baptist Health South Florida46 enrolled1 locationNCT05789589
Recruiting
Phase 2
Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer
Metastatic CancerLeptomeningeal MetastasisBrain Cancer+2 more
Memorial Sloan Kettering Cancer Center30 enrolled1 locationNCT06058988
Recruiting
Phase 1Phase 2
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease
HER2-positive Breast CancerLeptomeningeal DiseaseLeptomeningeal Metastasis
H. Lee Moffitt Cancer Center and Research Institute39 enrolled2 locationsNCT04588545
Recruiting
Phase 2
Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.
Leptomeningeal Metastasis
Guangzhou Medical University36 enrolled1 locationNCT06296745
Recruiting
Phase 2
A Prospective Single Arm Phase II Exploratory Study on the Combination of Whole Brain Radiotherapy, Thiotepa Intrathecal Injection and Systemic Treatment of Primary Diseases in the Treatment of Solid Tumor Leptomeningeal Metastasis
Solid Tumor Leptomeningeal Metastasis
Second Affiliated Hospital, School of Medicine, Zhejiang University58 enrolled1 locationNCT06376292
Recruiting
Phase 2
Phase II Trial of Albumin-Bound Paclitaxel Combined With Nedaplatin (TP) Via Hepatic Arterial Infusion for Advanced Breast Cancer Patients With Liver Metastases After Failure of Standard Therapy
Hepatic Artery InfusionLiver Metastasis of Breast Cancer
Zhejiang Cancer Hospital30 enrolled1 locationNCT07284836