Phase 2 Metastatic Cancer Clinical Trials
38 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 38 trials
Recruiting
Phase 2
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
Cervical CancerMetastatic CancerAnal Cancer+18 more
Christian Hinrichs20 enrolled3 locationsNCT05686226
Recruiting
Phase 2
Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.
Metastatic CancerCastrate Sensitive Prostate CancerNeoplasm, Prostate+1 more
Sun Pharmaceutical Industries Limited192 enrolled12 locationsNCT05422911
Recruiting
Phase 1Phase 2
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Colorectal, CancerProstate CancerCancer+12 more
Parabilis Medicines, Inc.595 enrolled33 locationsNCT05919264
Recruiting
Phase 2
KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting
GISTGIST - Gastrointestinal Stromal TumorGastrointestinal Tumors+2 more
Kumquat Biosciences Inc.46 enrolled8 locationsNCT07406633
Recruiting
Phase 1Phase 2
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
Advanced Solid TumorNon-small Cell Lung CancerMetastatic Cancer+1 more
Aulos Bioscience, Inc.159 enrolled18 locationsNCT05267626
Recruiting
Phase 2
Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)
Gastric CancerEsophageal AdenocarcinomaMetastatic Cancer+3 more
I-Mab Biopharma US Limited180 enrolled6 locationsNCT07432295
Recruiting
Phase 1Phase 2
A Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer
Locally AdvancedUnresectableMetastatic Cancers+1 more
Recursion Pharmaceuticals Inc.170 enrolled6 locationsNCT06678659
Recruiting
Phase 2
A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change
Metastatic Cancer
Memorial Sloan Kettering Cancer Center45 enrolled7 locationsNCT05010031
Recruiting
Phase 2Phase 3
Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers
FatigueMetastatic Cancers
M.D. Anderson Cancer Center240 enrolled1 locationNCT06085716
Recruiting
Phase 2
Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors
CancerMetastatic CancerLocally Advanced+2 more
University of Cincinnati37 enrolled1 locationNCT06416007
Recruiting
Phase 2
Biomarkers to Detect Endocrine Therapy Resistance
Breast CancerMetastatic CancerLobular Breast Carcinoma
University of Wisconsin, Madison8 enrolled1 locationNCT06067503
Recruiting
Phase 1Phase 2
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
Breast CancerBreast Cancer MetastaticOvarian Cancer+6 more
Incyclix Bio150 enrolled18 locationsNCT05735080
Recruiting
Phase 1Phase 2
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Ovarian CancerEndometrial CancerMetastatic Cancer+6 more
Artios Pharma Ltd442 enrolled79 locationsNCT04657068
Recruiting
Phase 1Phase 2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Breast CancerTriple-Negative Breast CancerColorectal, Cancer+26 more
PMV Pharmaceuticals, Inc300 enrolled76 locationsNCT04585750
Recruiting
Phase 1Phase 2
Safety and Efficacy of Allogeneic HPV-specific T Cells in Adults With Recurrent or Metastatic HPV16+ Cancers
HPV 16+ Recurrent or Metastatic Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins24 enrolled1 locationNCT04713046
Recruiting
Phase 1Phase 2
Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases
CancerMetastatic CancerMetastasis+2 more
Baptist Health South Florida46 enrolled1 locationNCT05789589
Recruiting
Phase 2
Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer
Metastatic CancerLeptomeningeal MetastasisBrain Cancer+2 more
Memorial Sloan Kettering Cancer Center30 enrolled1 locationNCT06058988
Recruiting
Phase 2
Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)
Metastatic CancerAdvanced CancerMalignant Neoplasm of Lung
Mirati Therapeutics Inc.200 enrolled120 locationsNCT05853575
Recruiting
Phase 2
Hybrid Arc Palliative Radiation Therapy (HART): A Single Arm Phase II Trial
Palliative RadiotherapyMetastatic Cancer (Different Solid Tumour Types)
University of Vermont Medical Center103 enrolled1 locationNCT06778408
Recruiting
Phase 2
Study of Cabozantinib and Nivolumab in Metastatic Castration Resistant Prostate Cancer
Metastatic CancerCastration-resistant Prostate Cancer
Rana McKay, MD47 enrolled4 locationsNCT05502315