Phase 1 Metastatic Castration-resistant Prostate Cancer Clinical Trials
34 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 34 trials
Recruiting
Phase 1
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
Breast CancerCervical CancerColon Cancer+4 more
Orano Med LLC48 enrolled4 locationsNCT05283330
Recruiting
Phase 1
First-in-human Study of 225Ac-PSMA-Trillium (BAY 3563254) in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)
Advanced Metastatic Castration-resistant Prostate CancerProstate Specific Membrane Antigen (PSMA) Expression
Bayer198 enrolled35 locationsNCT06217822
Recruiting
Phase 1Phase 2
Open-Label Study of Pocenbrodib Alone and in Combination With Abiraterone Acetate, Olaparib, or 177Lu-PSMA-617
Prostate CancerNeoplasmsNeoplasms by Site+7 more
Pathos AI, Inc.252 enrolled18 locationsNCT06785636
Recruiting
Phase 1
Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer
Prostate CancerMetastatic Castration-resistant Prostate CancerCastration-resistant Prostate Cancer
Janux Therapeutics43 enrolled1 locationNCT07545811
Recruiting
Phase 1Phase 2
Green Tea and Quercetin in Combination With Docetaxel Chemotherapy in Castration-resistant Prostate Cancer Patients
Metastatic Castration-resistant Prostate Cancer (mCRPC)
Charles Drew University of Medicine and Science99 enrolled1 locationNCT06615752
Recruiting
Phase 1Phase 2
A Study of MHB048C in Patients With Advanced Solid Tumors
Advanced Malignant Solid TumormCRPC (Metastatic Castration-resistant Prostate Cancer)
Minghui Pharmaceutical (Hangzhou) Ltd200 enrolled1 locationNCT07192120
Recruiting
Phase 1
Phase 1 Study of ACE-232 to Treat Patients With Metastatic Castration-Resistant Prostate Cancer
Prostate Cancer (Adenocarcinoma)mCRPC (Metastatic Castration-resistant Prostate Cancer)
Acerand Therapeutics (Hong Kong) Limited67 enrolled8 locationsNCT06801236
Recruiting
Phase 1Phase 2
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
Prostate CancerMetastatic Castration-resistant Prostate CancerUrogenital Neoplasms+3 more
Blue Earth Therapeutics Ltd82 enrolled23 locationsNCT05413850
Recruiting
Phase 1Phase 2
Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer
Prostate CancermCRPC (Metastatic Castration-resistant Prostate Cancer)Prostatic Neoplasms, Castration-Resistant+3 more
Celcuity Inc54 enrolled13 locationsNCT06190899
Recruiting
Phase 1
TSL2109 Capsules in Advanced Solid Tumor Patients: Safety, Tolerability, PK and Preliminary Efficacy
Metastatic Castration-Resistant Prostate Cancer Patients
Tasly Pharmaceutical Group Co., Ltd78 enrolled1 locationNCT07514065
Recruiting
Phase 1
Autologous Gamma Delta T Cells to Target Prostate Stem Cell Antigen in mCRPC
Metastatic Castration-resistant Prostate Cancer
H. Lee Moffitt Cancer Center and Research Institute30 enrolled1 locationNCT06193486
Recruiting
Phase 1
A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)
Metastatic Castration-resistant Prostate CancerMetastatic Castration-Resistant Prostate Cancer Patients
K36 Therapeutics, Inc.144 enrolled13 locationsNCT07103018
Recruiting
Phase 1
Novel ACK1 Inhibitor (R)-9b in Patients With Prostate Cancer
Metastatic Castration-resistant Prostate Cancer (CRPC)
TechnoGenesys, Inc.40 enrolled1 locationNCT06705686
Recruiting
Phase 1Phase 2
64Cu-GRIP B in Patients With Advanced Malignancies
Prostate CancerAdvanced Solid TumorSolid Tumor, Adult+3 more
Rahul Aggarwal91 enrolled1 locationNCT05888532
Recruiting
Phase 1Phase 2
A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer
Metastatic Castration-resistant Prostate Cancer
Regeneron Pharmaceuticals370 enrolled14 locationsNCT05125016
Recruiting
Phase 1
A Study of DS9051b in Participants With Advanced or Metastatic Adrenocortical Carcinoma and Metastatic Castration-resistant Prostate Cancer
Metastatic Castration-resistant Prostate CancerAdvanced or Metastatic Adrenocortical Carcinoma
Daiichi Sankyo40 enrolled6 locationsNCT07189403
Recruiting
Phase 1Phase 2
Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors
Advanced HR+/HER2- Breast CancerAdvanced CCNE1-amplified Solid TumorsMetastatic Castration-resistant Prostate Cancer
Novartis Pharmaceuticals205 enrolled4 locationsNCT07288359
Recruiting
Phase 1Phase 2
Phase Ib/IIa Dose Escalation and Expansion Study of [²¹²Pb]Pb-ADVC001 in Metastatic Prostate Cancer (TheraPb - Phase I/II Study).
Prostate CancerMetastatic Castration-resistant Prostate CancerMetastatic Hormone Sensitive Prostate Cancer
AdvanCell Pty Limited100 enrolled3 locationsNCT05720130
Recruiting
Phase 1
A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer
Metastatic Castration-resistant Prostate Cancer
Bristol-Myers Squibb140 enrolled8 locationsNCT06067841
Recruiting
Phase 1
A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)
Metastatic Castration-resistant Prostate Cancer
Daiichi Sankyo60 enrolled6 locationsNCT07244341