Phase 1 Metastatic Head and Neck Squamous Cell Carcinoma Clinical Trials

5 recruitingPhase 1

What is a Phase 1 trial?

Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.

Showing 1–5 of 5 trials

Recruiting

Phase 1Phase 2

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Triple-Negative Breast Carcinoma+97 more

Mayo Clinic132 enrolled1 locationNCT05269381

Recruiting

Phase 1

Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell Carcinoma

Metastatic Head and Neck Squamous Cell CarcinomaRefractory Head and Neck Squamous Cell CarcinomaLocally Recurrent Head and Neck Squamous Cell Carcinoma

University of California, Davis24 enrolled2 locationsNCT06211335

Recruiting

Phase 1

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

Metastatic Head and Neck Squamous Cell CarcinomaStage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8Recurrent Head and Neck Squamous Cell Carcinoma+20 more

Emory University40 enrolled2 locationsNCT06868433

Recruiting

Phase 1

(89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma

Head and Neck Squamous Cell CarcinomaMetastatic Head and Neck Squamous Cell CarcinomaStage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck

Eben Rosenthal60 enrolled1 locationNCT05747625

Recruiting

Phase 1Phase 2

A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab

Metastatic Head and Neck Squamous Cell CarcinomaMetastatic Pancreatic CancerMetastatic Prostate Cancer

ImmunoGenesis71 enrolled1 locationNCT06782555