Phase 1 Migraine Clinical Trials
13 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–13 of 13 trials
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine
Acute Treatment of Migraine
Pfizer16 enrolled13 locationsNCT06995729
Not Yet Recruiting
Phase 1
Does middle meningeal artery embolisation reduce headache severity in adults with chronic migraine?
Chronic Migraine
South West Sydney - Local Health District40 enrolled1 locationACTRN12625000597493
Completed
Phase 1
A First-In-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-645 in Healthy Volunteers
Migraine
Kallyope, Inc.16 enrolled1 locationACTRN12624001241527
Withdrawn
Phase 1
A Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-3505 in Healthy Volunteers (PART II)
Migraine
KALLYOPE, Inc.12 enrolled1 locationACTRN12624001026516
Withdrawn
Phase 1
A Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-3505 in Healthy Volunteers (PART I).
Migraine
KALLYOPE, Inc.28 enrolled1 locationACTRN12624000990527
Completed
Phase 1
A Study to Evaluate Single Doses of Dihydroergotamine Mesylate Inhalation Powder and Dihydroergotamine Mesylate Intravenous in Healthy Adult Subjects
Acute Migraine
Syneos Health New Zealand Ltd28 enrolled1 locationACTRN12623001201662
Completed
Phase 1
A Phase 1, Randomised, Double-Blind, Placebo-Controlled, First-in-Human Study of the Safety, Tolerability and Pharmacokinetics of AXN-001 in Healthy Volunteers.
Migraine
Avance Clinical Pty Ltd56 enrolled1 locationACTRN12623000296639
Completed
Phase 1
Safety, Tolerability and Pharmacokinetics of ALD1910
Migraine
Alder BioPharmaceuticals, Inc.96 enrolled1 locationACTRN12619001380189
Completed
Phase 1
Crossover Comparison of the Tolerability and Pharmacokinetics of ZP-Zolmitriptan Intracutaneous Microneedle System with Oral Zolmitriptan and Subcutaneous (SC) Sumatriptan in Healthy Volunteers
Migraine
Pharmaceutical Solutions Ltd20 enrolled1 locationACTRN12616000050459
Completed
Phase 1
Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of ALD403
Migraine
Alder BioPharmaceuticals, Inc.60 enrolled1 locationACTRN12615000531516
Completed
Phase 1
Safety, Pharmacokinetics and Pharmacodynamics of ALD403
Migraine
Alder Biopharmaceuticals60 enrolled1 locationACTRN12614000681651
Completed
Phase 1
Evaluation of the Pharmacokinetics and Safety of Dihydroergotamine Administered Via Two Intranasal Delivery Devices
Migraine
Impax Laboratories, Inc14 enrolled1 locationACTRN12614000330640
Recruiting
Phase 1
Feasibility Clinical Study of the Ovalis, Inc. Patent Foramen Ovale (PFO) Closure System in Patients with Cryptogenic Neurologic Events, Migraines, and Decompression Illness
Patients with cryptogenic neurologic events, migraines and decompression illness due to patent foramen ovale
Robust Industries30 enrolled1 locationACTRN12606000407594