Phase 2 Multiple Sclerosis Clinical Trials
51 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 51 trials
Recruiting
Phase 1Phase 2
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
Multiple Sclerosis
National Institute of Allergy and Infectious Diseases (NIAID)250 enrolled1 locationNCT03109288
Recruiting
Phase 2
A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
Multiple Sclerosis
ModernaTX, Inc.180 enrolled17 locationsNCT06735248
Recruiting
Phase 2
Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis
InsomniaMultiple Sclerosis
University of Kansas Medical Center70 enrolled1 locationNCT06428006
Recruiting
Phase 2
A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)
Relapsing Multiple Sclerosis
Hoffmann-La Roche12 enrolled17 locationsNCT07161258
Recruiting
Phase 2
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Multiple Sclerosis Spasticity
Celgene200 enrolled54 locationsNCT06782490
Recruiting
Phase 2
Solriamfetol for the Treatment of Multiple Sclerosis Fatigue
Multiple SclerosisMultiple Sclerosis Fatigue
Johns Hopkins University46 enrolled1 locationNCT06170970
Recruiting
Phase 2
Hyperpolarized Carbon Metabolic Imaging in Multiple Sclerosis
Multiple SclerosisRRMSRelapsing Remitting MS
Ari Green40 enrolled1 locationNCT07510607
Recruiting
Phase 2
Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques
Multiple Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)30 enrolled1 locationNCT02784210
Recruiting
Phase 1Phase 2
An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple Sclerosis
Relapsing Multiple Sclerosis
Novartis Pharmaceuticals28 enrolled18 locationsNCT06617793
Recruiting
Phase 2
A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)
Multiple Sclerosis
Hoffmann-La Roche182 enrolled56 locationsNCT07074886
Recruiting
Phase 2
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
Progressive Multiple Sclerosis
Hoffmann-La Roche360 enrolled73 locationsNCT07282574
Recruiting
Phase 1Phase 2
MB-CART2019.1 in Refractory Multiple Sclerosis
Multiple SclerosisCAR-T Cell Therapy
Miltenyi Biomedicine GmbH26 enrolled1 locationNCT07178431
Recruiting
Phase 2
Psilocybin Therapy for Psychological Distress in Palliative Patients
COPD, Chronic Obstructive Pulmonary DiseaseMajor Depressive Disorder (MDD)ALS (Amyotrophic Lateral Sclerosis)+2 more
University Medical Center Groningen108 enrolled4 locationsNCT06782724
Recruiting
Phase 2
Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis
Multiple Sclerosis
Johns Hopkins University120 enrolled1 locationNCT07497399
Recruiting
Phase 1Phase 2
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
Multiple SclerosisMultiple Sclerosis (MS) Primary ProgressiveMultiple Sclerosis (MS) Secondary Progressive+2 more
Tr1X, Inc.39 enrolled2 locationsNCT07477639
Recruiting
Phase 2
The Effect of Rituximab on Cognitive and Hand Functions in Secondary Progressive Multiple Sclerosis
Secondary-progressive Multiple Sclerosis (SPMS)
Cairo University46 enrolled1 locationNCT06599307
Recruiting
Phase 1Phase 2
Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy
Multiple Sclerosis (MS)Multiple Sclerosis, Relapsing-RemittingMultiple Sclerosis, Primary Progressive+4 more
University of California, San Francisco74 enrolled1 locationNCT05359653
Not Yet Recruiting
Phase 2
A Multicenter, Randomized, Fixed Sequence, Cross-over Study to Assess the Safety, Tolerability, and Pharmacokinetics of MRX-4TZT TDS (Tizanidine Transdermal Delivery System) versus Oral Tizanidine in Multiple Sclerosis Patients with Established Spasticity
Multiple SclerosisSpasticity
MEDRx Australia Pty Ltd80 enrolled1 locationACTRN12626000112369
Recruiting
Phase 1Phase 2
Molecular Imaging of NET Using [C-11]MRB-PET in MS
Multiple Sclerosis
Brigham and Women's Hospital19 enrolled1 locationNCT03207464
Recruiting
Phase 1Phase 2
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
Multiple SclerosisAlzheimer s Disease
Brigham and Women's Hospital250 enrolled1 locationNCT02649985