Muscle Clinical Trials

489 recruitingLast updated: July 25, 2026

There are 489 actively recruiting muscle clinical trials across 58 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include New York, New York, United States, Boston, Massachusetts, United States, Los Angeles, California, United States. Updated daily from ClinicalTrials.gov.


Muscle Trials at a Glance

489 actively recruiting trials for muscle are listed on ClinicalTrialsFinder across 6 cities in 58 countries. The largest study group is Not Applicable with 249 trials, with the heaviest enrollment activity in New York, Boston, and Los Angeles. Lead sponsors running muscle studies include Riphah International University, Cairo University, and Assiut University.

Treatments under study

About Muscle Clinical Trials

Looking for clinical trials for Muscle? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Muscle trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Muscle clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 489 trials

Recruiting

Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults

Muscle WeaknessProblems Moving Their Arms and Legs
National Institutes of Health Clinical Center (CC)23 enrolled1 locationNCT06998134
Recruiting

Tumor-informed ctDNA in Muscle-invasive Bladder Cancer for Evaluation of Residual/Recurrent Disease - the TiMBER Trial

Muscle Invasive Bladder Urothelial CarcinomaStage II Bladder Cancer AJCC v8Stage IIIA Bladder Cancer AJCC v8
OHSU Knight Cancer Institute100 enrolled1 locationNCT07726602
Recruiting
Phase 2

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

Stage I Bladder Cancer AJCC v8Non-Muscle Invasive Bladder Urothelial CarcinomaRecurrent Non-Muscle Invasive Bladder Urothelial Carcinoma
National Cancer Institute (NCI)160 enrolled134 locationsNCT06770582
Recruiting
Phase 2Phase 3

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Muscle Invasive Bladder Urothelial CarcinomaStage IV Bladder Urothelial Carcinoma AJCC v7Muscle Invasive Renal Pelvis Urothelial Carcinoma+4 more
National Cancer Institute (NCI)992 enrolled499 locationsNCT05987241
Recruiting
Phase 1

A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

Non Muscle Invasive Bladder Cancer
Pfizer294 enrolled68 locationsNCT07206225
Recruiting
Not Applicable

Prebiotic Inulin for Late-Reproductive Individuals

Insulin ResistanceObesity, OverweightMicrobiota+9 more
George Washington University27 enrolled1 locationNCT07724522
Recruiting
Not Applicable

Acute Effects of Neurodynamics on Strength and Endurance in Athletes

hamstring muscle tightnessHamstring injuriesHamstring Muscle Strain+8 more
High Point University45 enrolled1 locationNCT07721220
Recruiting
Phase 2

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

Muscle Invasive Bladder Urothelial CarcinomaStage II Bladder Cancer AJCC v8Stage IIIA Bladder Cancer AJCC v8
National Cancer Institute (NCI)111 enrolled159 locationsNCT07061964
Recruiting
Phase 3

An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC

High-risk Muscle Invasive Urothelial Carcinoma
AstraZeneca915 enrolled160 locationsNCT07720284
Recruiting

The Relationship Between Transversus Abdominis Muscle Architecture and Upper Extremity Function in Patients With Chronic Low Back Pain

UltrasoundLow Back PainScapular Dyskinesis+2 more
Ilayda Dilan Isik90 enrolled1 locationNCT07474610
Recruiting
Phase 1

Adaptive RADiation Therapy With Concurrent Sacituzumab Govitecan (SG) for Muscle Invasive Bladder Cancer

Muscle-Invasive Bladder CarcinomaLocalized Muscle Invasive Bladder Urothelial Carcinoma
Shilpa Gupta, MD20 enrolled1 locationNCT05833867
Recruiting
Not Applicable

Pro-social Power Training Activity for Aging and Well-being With Chronic Kidney Disease

Lower Extremity Muscle Strength
VA Office of Research and Development30 enrolled1 locationNCT06089057
Recruiting
Not Applicable

Transversus Thoracic Muscle Plane Block Versus Pectointercostal Fascial Block for Enhanced Recovery After Cardiac Surgery

Cardiac SurgeryTransversus Thoracic Muscle Plane BlockPecto-intercostal Fascial Block+1 more
Assiut University90 enrolled1 locationNCT07417462
Recruiting
Early Phase 1

Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction

Voice disordersMuscle Tension DysphoniaVocal Fold Polyp+1 more
Massachusetts General Hospital100 enrolled2 locationsNCT05970562
Recruiting
Phase 1

Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

MelanomaNon-small Cell Lung CancerMuscle-Invasive Bladder Carcinoma+1 more
Washington University School of Medicine64 enrolled3 locationsNCT06529822
Recruiting
Phase 2

A Study to Find Out if Enfortumab Vedotin Given With Pembrolizumab Helps People With Muscle-invasive Bladder Cancer Keep Their Bladder

Muscle Invasive Bladder Cancer
Astellas Pharma Global Development, Inc.240 enrolled12 locationsNCT07475806
Recruiting
Not Applicable

Nordic vs Blood Flow Restriction Nordic Exercise in Elite Female Pole Vaulters

Sports injury preventionAthletic PerformanceMuscle Strength+1 more
Toros University36 enrolled1 locationNCT07705698
Recruiting
Phase 1Phase 2

CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy

Age-related Muscle Decline
Unlimited Biotechnology LLC12 enrolled1 locationNCT07443826
Recruiting
Not Applicable

Evaluation of Muscle Oxygen With MRI

Muscle Oxygenation
Icahn School of Medicine at Mount Sinai75 enrolled1 locationNCT07638384
Recruiting
Phase 1Phase 2

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)

Non Muscle Invasive Bladder Cancer
Merck Sharp & Dohme LLC32 enrolled13 locationsNCT06637423