Older Clinical Trials

189 recruitingLast updated: June 18, 2026

There are 189 actively recruiting older clinical trials across 36 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1. Top locations include New York, New York, United States, Boston, Massachusetts, United States, Hong Kong, Hong Kong. Updated daily from ClinicalTrials.gov.


Older Trials at a Glance

189 actively recruiting trials for older are listed on ClinicalTrialsFinder across 6 cities in 36 countries. The largest study group is Not Applicable with 117 trials, with the heaviest enrollment activity in New York, Boston, and Hong Kong. Lead sponsors running older studies include The Hong Kong Polytechnic University, Istituto Nazionale di Ricovero e Cura per Anziani, and Peking University First Hospital.

Browse older trials by phase

Treatments under study

About Older Clinical Trials

Looking for clinical trials for Older? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Older trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Older clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 189 trials

Recruiting
Phase 2

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma

Smoldering Multiple Myeloma (SMM)Monoclonal Gammopathy of Undetermined Significance (MGUS)
Regeneron Pharmaceuticals116 enrolled39 locationsNCT06140524
Recruiting
Phase 2

Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias

Older Adults With Elevated Dementia Risk
University of South Carolina54 enrolled1 locationNCT07638046
Recruiting
Not Applicable

Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults

Healthy Older Adults
Florida State University30 enrolled1 locationNCT07649005
Recruiting
Not Applicable

Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline

Older AdultsPhysical InactivityPhysical Activity+4 more
The University of Tennessee, Knoxville64 enrolled2 locationsNCT07207993
Recruiting
Not Applicable

Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health

Cognitive DeclineStrokeLoneliness+1 more
Universidad de Especialidades Espiritu Santo500 enrolled1 locationNCT07319663
Recruiting
Phase 3

A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)

High Risk Smoldering Multiple Myeloma (HR-SMM)
Regeneron Pharmaceuticals270 enrolled1 locationNCT07393282
Recruiting
Not Applicable

Video Intervention for Older Adults With Chronic Pain

Musculoskeletal PainChronic PainOlder Adults With Chronic Pain
Butler Hospital100 enrolled1 locationNCT07404618
Recruiting
Phase 1

A Study of Psychedelics in Healthy Older Adults With Low Well-being

Older Adults (50-90 Years)Anhedonia in Healthy Volunteers
Jennifer Mitchell80 enrolled1 locationNCT07386730
Recruiting
Not Applicable

Mitigation of Health Effects in Older Adults With Hypertension by Reducing Exposure to Heat and Air Pollution

Hypertension Arterial65 Years Older
University of Cyprus102 enrolled2 locationsNCT07606859
Recruiting

Physical and Cognitive Aging Study in Older Adults

ExerciseOlder Adults (65 Years and Older)Cognitive Aging+2 more
University of Florida100 enrolled1 locationNCT06726616
Recruiting
Not Applicable

Increasing Gait Automaticity in Older Adults by Exploiting Locomotor Adaptation

Community Mobility of Older AdultsLocomotor AdaptabilityGait Automaticity
University of Pittsburgh42 enrolled1 locationNCT04934956
Recruiting
Not Applicable

CAPABLE Care + Connect

Quality of LifeDisability PhysicalSocial Isolation or Loneliness+3 more
Johns Hopkins University450 enrolled1 locationNCT07123298
Recruiting
Not Applicable

Pharyngeal Exercise (Plus Protein)

Pre-Frail Older Adults
NYU Langone Health120 enrolled2 locationsNCT05963113
Recruiting
Not Applicable

Motivational Interviewing to Enhance Advance Care Planning for Older Adults and Caregivers After Emergency Visits

Older AdultsFamily MembersAdvance Care Planning+1 more
The University of Hong Kong300 enrolled1 locationNCT06090240
Recruiting
Not Applicable

How Video Game Therapy Affects Thinking and Emotions in Older Adults With Cognitive Impairment

Older Adults (65 Years and Older)Cognitive Impairment, Mild
Golden Gamers Go SL60 enrolled1 locationNCT07615647
Recruiting
Not Applicable

Zinc Supplementation and Infections in Older Medical Patients

Older Adults (65 Years and Older)Medical Patients in the Emergency Department
Herlev Hospital8,000 enrolled2 locationsNCT07367412
Recruiting
Not Applicable

Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health

Cardiometabolic healthHealthy AgingBrain Health+2 more
South Dakota State University20 enrolled1 locationNCT07623785
Recruiting
Phase 2

Iberdomide Alone or in Combination With Dexamethasone for the Treatment of Intermediate- or High-Risk Smoldering Multiple Myeloma

Smoldering Plasma Cell Myeloma
Emory University68 enrolled1 locationNCT04776395
Recruiting
Phase 2Phase 3

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

Indolent Systemic MastocytosisSmoldering Systemic Mastocytosis
Blueprint Medicines Corporation534 enrolled68 locationsNCT04910685
Recruiting

Frailty in Older Adults With Prostate Cancer: a Prospective Cohort Study

Prostate CancerFrailty at Older Adults
University of Limerick80 enrolled1 locationNCT07605936