Otitis Media Clinical Trials

22 recruitingLast updated: May 13, 2026

There are 22 actively recruiting otitis media clinical trials across 8 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3. Top locations include Caen, France, Cherry Hill, New Jersey, United States, Chicago, Illinois, United States. Updated daily from ClinicalTrials.gov.


Otitis Media Trials at a Glance

22 actively recruiting trials for otitis media are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Not Applicable with 10 trials, with the heaviest enrollment activity in Caen, Cherry Hill, and Chicago. Lead sponsors running otitis media studies include Menzies School of Health Research, Telethon Kids Institute, and Curtin University.

Browse otitis media trials by phase

Treatments under study

About Otitis Media Clinical Trials

Looking for clinical trials for Otitis Media? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Otitis Media trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Otitis Media clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 22 trials

Recruiting
Phase 2

Safety and Efficacy of wSp Vaccine in Young Children

Acute Otitis Media (AOM)
Serum Life Science Europe GmbH320 enrolled4 locationsNCT07216430
Recruiting
Not Applicable

Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma

Pediatric AsthmaAsthma ExacerbationAcute Otitis Media (AOM)+1 more
Medentum Innovations84 enrolled1 locationNCT07500532
Recruiting
Not Applicable

Laser Acupuncture for Otitis Media With Effusion in Children

Otitis Media with Effusion
Indonesia University32 enrolled1 locationNCT07242001
Recruiting
Not Applicable

Coherent Optical Detection of Middle Ear Disease

Otitis MediaOtitis Media AcuteOtitis Media with Effusion
Medical College of Wisconsin235 enrolled2 locationsNCT05353569
Recruiting
Not Applicable

Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care

AnginaAcute BronchiolitisAcute Bronchitis+8 more
University Hospital, Caen4,500 enrolled1 locationNCT07359287
Recruiting
Not Applicable

Artificial Intelligence Diagnostic Decision Support to Reduce Antimicrobial Prescriptions in Young Children With Colds

Acute Otitis Media (AOM)Upper Respiratory Infection
Timothy Shope300 enrolled2 locationsNCT06876259
Recruiting
Not Applicable

Perspectives on Antibiotics and Tracking Symptoms in Children

PharyngitisOtitis MediaCellulitis+4 more
Murdoch Childrens Research Institute300 enrolled1 locationNCT07093749
Recruiting
Not Applicable

Interventions to De-implement Unnecessary Antibiotic Prescribing for Children With Ear Infections

Ear InfectionPediatric Infectious DiseaseAcute Otitis Media
Intermountain Health Care, Inc.1,566 enrolled3 locationsNCT06034080
Recruiting
Not Applicable

Effect of Chitodex Gel in Tympanoplasty Surgery

Otitis Mediatympanic membrane perforationSurgery+1 more
Central Adelaide Local Health Network Incorporated44 enrolled2 locationsNCT06260618
Recruiting

Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry

Otitis MediaOtitis Media with EffusionAcute Otitis Media
Smith & Nephew, Inc.200 enrolled6 locationsNCT05915078
Recruiting
Not Applicable

Respiratory Tract Microbiome and Probiotics in Children With Cleft Palate

Cleft Palate ChildrenOtitis Media in Children
University Hospital, Antwerp40 enrolled1 locationNCT06505330
Recruiting
Phase 4

Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present

Otitis Media
Boston Children's Hospital125 enrolled1 locationNCT03655665
Recruiting
Not Applicable

Effect of Ventilation Tubes in Otitis-prone Children

Recurrent acute otitis media
Lund University150 enrolled1 locationNCT05348291
Recruiting

Sound Ear Check (SEC) in Hearing Diagnostics in Young Children

Hearing LossTympanostomyOtitis Media with Effusion
Vesa Lahdes100 enrolled1 locationNCT05535634
Recruiting

Perth Children's Hospital (PCH) Healthy Ears: A telehealth-facilitated randomised-controlled trial utilising a health promotion intervention to resolve otitis media with effusion for children on specialist Ear, Nose and Throat (ENT) waiting lists.

Otitis Media with Effusion
Telethon Kids Institute250 enrolled1 locationACTRN12622000546752
Recruiting

Deadly Ears in Deadly Hands: Aboriginal Health Professional-led ear and hearing assessment and discharge planning for Aboriginal children at risk of severe ear infection

severe otitis media
Menzies School of Health Research600 enrolled1 locationACTRN12622000478718
Recruiting

A non-invasive treatment for Otitis Media with Effusion

otitis media with effusion (OME)
Curtin University25 enrolled1 locationACTRN12621000949886
Recruiting
Phase 2

ATOMIC Ears: A Phase IIB randomised controlled trial to assess safety, tolerability and acceptability of a 5-day Dornase alfa treatment as an adjunct therapy to ventilation tube insertion for otitis media in children

Recurrent acute otitis mediaChronic otitis media with effusion ("glue ear")
Telethon Kids Insitute120 enrolled5 locationsACTRN12619001306101
Recruiting

Cockburn Ear Portal: An Ears, Nose and Throat (ENT) and Audiology referral portal for improving access to ear health services for Aboriginal children in metropolitan areas using telehealth

Otitis Media
Telethon Kids Institute120 enrolled1 locationACTRN12619000040167
Recruiting

PCH Ear Portal: An urban-based Ears, Nose and Throat (ENT) and Audiology referral telehealth portal to provide equitable access to specialist ear health services for children

Otitis Media
Telethon Kids Institute360 enrolled1 locationACTRN12619000039189