Phase 1 Pharmacokinetic Clinical Trials
27 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 27 trials
Recruiting
Phase 1
Comparing the Extent to Which Two Evolocumab Drug Products Are Made Available in the Body After a Single Subcutaneous Dose
Healthy ParticipantsPharmacokinetics
Amgen400 enrolled5 locationsNCT07422285
Recruiting
Phase 1
Pharmacokinetics of Sulopenem Etzadroxil Plus Probenecid in Adolescents
Pharmacokinetics After Oral Intake
Iterum Therapeutics, International Limited12 enrolled1 locationNCT07092813
Recruiting
Phase 1
Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With Nafamostat (PF614-MPAR-102)
Pharmacokinetics
Ensysce Biosciences30 enrolled1 locationNCT06500793
Recruiting
Phase 1
Acute Effects of Oral Nicotine Pouches
Nicotine Pouch Self-AdministrationNicotine Pharmacokinetic StudyNicotine Pharmacodynamic Study
Johns Hopkins University120 enrolled1 locationNCT07128329
Recruiting
Phase 1
A Phase 1 Ethnobridging TriaL of AGA2118 in Healthy Japanese, Chinese, and Caucasian ParticipantS (ATLAS)
Healthy ParticipantsPharmacokinetic Study
Angitia Incorporated Limited30 enrolled1 locationNCT07361354
Recruiting
Phase 1
Pharmacokinetics of Olverembatinib in Participants With Hepatic Impairment
PharmacokineticOlverembatinib
Ascentage Pharma Group Inc.48 enrolled1 locationNCT07282093
Recruiting
Phase 1
Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination
Healthy VolunteerSafetyPharmacokinetics+2 more
Basilea Pharmaceutica46 enrolled1 locationNCT06733675
Recruiting
Phase 1
Study of BB-025, Alone and After BB-031, in Healthy Volunteers
Healthy VolunteersPharmacokineticsPharmacodynamics
Basking Biosciences, Inc.72 enrolled1 locationNCT07202663
Recruiting
Phase 1
Safety, Tolerability, and Pharmacokinetics of RCS-21 in Healthy Volunteers.
SafetyHealthy VolunteersTolerability+1 more
RNATICS GmbH24 enrolled1 locationNCT06752122
Recruiting
Phase 1
High Potency Cannabis: Acute and Protracted Effects
PainPharmacokineticsAbuse Cannabis
University of California, Los Angeles30 enrolled1 locationNCT06859723
Recruiting
Phase 1Phase 2
Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors
Safety IssuesTolerabilityPharmacokinetics
Nanjing Immunophage Biotech Co., Ltd196 enrolled7 locationsNCT05142592
Recruiting
Phase 1
Food Effect on PK of DW-1021 (Pelubiprofen 45 mg / Tramadol 45.9 mg) in Healthy Adults
Healthy VolunteersPharmacokineticsFood Effect in Healthy Volunteers
Haiphong University of Medicine and Pharmacy14 enrolled2 locationsNCT07060209
Recruiting
Phase 1
Vancomycin Dose Optimization in Obesity
Pharmacokinetics and Pharmacodynamics
University of Michigan24 enrolled1 locationNCT06601257
Recruiting
Phase 1
Relative Bioavailability of Two Orally Administered CBD Formulations in Healthy Male Adults
Pharmacokinetics
University of Saskatchewan20 enrolled1 locationNCT06574100
Recruiting
Phase 1
Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects
Pharmacokinetics
Modern Biosciences Ltd48 enrolled1 locationNCT06379958
Suspended
Phase 1
Effect of probenecid on the pharmacokinetics of cefalexin in children
antibiotic pharmacokinetics
A/Prof Tony Walls18 enrolled1 locationACTRN12619000959178
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of atorvastatin oral spray against the innovator atorvastatin capsule conducted under fasting conditions in healthy male and female volunteers
Pilot pharmacokinetic study conducted in healthy volunteers comparing two formulations of atorvastatin (oral spray and capsule) with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, atorvastatin is used as an adjunct to diet for the treatment of patients with hypercholesterolaemia.
Zenith Technology Corp Ltd10 enrolled1 locationACTRN12618000208202
Completed
Phase 1
Intravenous pentoxifylline as adjunct therapy in preterm infants with late-onset sepsis or necrotizing enterocolitis
Pentoxifylline pharmacokineticsPreterm infant
Tobias Strunk23 enrolled1 locationACTRN12616000219482
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of Inhaled Insulin against the innovators Humalog KwikPen for injection and the AFREZZA Inhalation Powder Cartridge conducted under fasting conditions in healthy male and female volunteers
Pharmacokinetic and pharmacodynamic study conducted in healthy volunteers comparing three formulations of Insulin with no health condition or problem studied.
Insulin is a medicine that is used to lower blood glucose.
Zenith Technology Corp Ltd18 enrolled1 locationACTRN12615001100583
Completed
Phase 1
A Phase I, Randomised, Open Label Study of the Safety, Tolerability and Pharmacokinetics of Single Sublingual or Oral Dose of GDN-1 in Adult Healthy Volunteers.
This trial is to assess the tolerability and pharmacokinetics in healthy adult volunteers and does not focus on any particular health condition or problem.
Subsequent studies are planned to evaluate efficacy in promoting improved exercise endurance and recovery, reduced muscle damage and soreness post exercise and for its lipid lowering effects in appropriate populations.
Gordagen Pharmaceuticals Pty Ltd60 enrolled1 locationACTRN12615000560594