Prosthetic joint infection Clinical Trials

29 recruitingLast updated: June 18, 2026

There are 29 actively recruiting prosthetic joint infection clinical trials across 11 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4. Top locations include Boston, Massachusetts, United States, New York, New York, United States, Lyon, France. Updated daily from ClinicalTrials.gov.


Prosthetic joint infection Trials at a Glance

29 actively recruiting trials for prosthetic joint infection are listed on ClinicalTrialsFinder across 6 cities in 11 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Boston, New York, and Lyon. Lead sponsors running prosthetic joint infection studies include Hospices Civils de Lyon, First Affiliated Hospital of Fujian Medical University, and Assistance Publique - Hôpitaux de Paris.

Browse prosthetic joint infection trials by phase

Treatments under study

About Prosthetic joint infection Clinical Trials

Looking for clinical trials for Prosthetic joint infection? There are currently 18 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Prosthetic joint infection trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Prosthetic joint infection clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 29 trials

Recruiting

Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care.

Intensive care patientsProsthetic joint infectionOsteoarticular Infections
Assistance Publique - Hôpitaux de Paris150 enrolled1 locationNCT07107685
Recruiting
Phase 3

Infection Prophylaxis in Total Joint Replacement

Periprosthetic Joint Infection
Hamilton Health Sciences Corporation21,006 enrolled1 locationNCT06126614
Recruiting
Phase 2

Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections

Periprosthetic Joint Infection
OsteoRemedies, LLC60 enrolled3 locationsNCT06428448
Recruiting
Phase 2Phase 3

Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty

Prosthetic joint infection
Peptilogics240 enrolled9 locationsNCT07214311
Recruiting
Phase 1

Methylene Blue in Total Knee Arthroplasty (TKA)

Total Knee ArthroplastyProsthetic joint infectionIrrigation
University of Miami20 enrolled1 locationNCT07324954
Recruiting
Not Applicable

Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection

Arthroplasty ComplicationsProsthetic joint infectionKnee Infection+2 more
Northwestern University153 enrolled1 locationNCT06293352
Recruiting

Long Term Follow-up of Patients With Prosthetic Joint Infection of the Hip Treated at University Hospitals Leuven

Prosthetic joint infectionHip Prosthesis Infection
Universitaire Ziekenhuizen KU Leuven50 enrolled1 locationNCT05000723
Recruiting
Not Applicable

Reduction of Bacterial Seeding in Total Shoulder Arthroplasty

Prosthetic joint infectionShoulderCutibacterium Acnes+1 more
St. Louis University60 enrolled1 locationNCT07406893
Recruiting
Phase 1Phase 2

A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants

Periprosthetic Joint Infection (PJI)
TenNor Therapeutics Inc.33 enrolled1 locationNCT06889701
Recruiting
Not Applicable

The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infection of the Hip and Knee

Prosthetic joint infection
NYU Langone Health152 enrolled1 locationNCT06919913
Recruiting
Not Applicable

IP-coated Revision Hip Implants

Peri-Prosthetic Joint Infection
Aesculap AG268 enrolled2 locationsNCT06737809
Recruiting
Not Applicable

Rifampin-combined Antibiotic Therapy for Staphylococcal PJI

Periprosthetic Joint Infection
First Affiliated Hospital of Fujian Medical University428 enrolled1 locationNCT07313215
Recruiting
Phase 4

The Use of CCK vs PS in Revision TKAs

Aseptic Loosening of Prosthetic JointInstability of Prosthetic JointReimplantation for Periprosthetic Joint Infection+2 more
Rush University Medical Center170 enrolled1 locationNCT06782295
Recruiting
Phase 2

Study to Evaluate the Efficacy and Safety of TRL1068 for the Treatment of Prosthetic Joint Infection

Prosthetic Joint Infections of HipProsthetic Joint Infections of Knee
Trellis Bioscience LLC60 enrolled17 locationsNCT06621251
Recruiting

Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Markers

Prosthetic joint infection
Istituto Ortopedico Rizzoli270 enrolled1 locationNCT04858217
Recruiting

A Diagnostic Test Accuracy Study Comparing Biopsy to Aspiration in Shoulder and Elbow Arthroplasty Revision Surgery (BASE Study)

Periprosthetic Joint Infection
Wrightington, Wigan and Leigh NHS Foundation Trust244 enrolled1 locationNCT06268795
Recruiting
Phase 2Phase 3

Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement.

Antibiotic Resistant InfectionOsteoarthritis, HipProsthetic joint infection+1 more
University Hospital, Linkoeping1,100 enrolled1 locationNCT05169229
Recruiting

OsteoArticular Sepsis in Intensive Care unitS

Intensive care patientsProsthetic joint infectionOsteoarticular Infection
Assistance Publique - Hôpitaux de Paris150 enrolled1 locationNCT06627842
Recruiting

Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections

Prosthetic joint infection
University Hospital, Brest143 enrolled1 locationNCT06062251
Recruiting

Molecular Biology in the Identification of Pathogens at Reimplantation in the Two-Stage Treatment of Periprosthetic Infections

Periprosthetic Joint Infection (PJI)
IRCCS Azienda Ospedaliero-Universitaria di Bologna100 enrolled1 locationNCT06804265