Phase 1 Protein Clinical Trials
19 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–19 of 19 trials
Recruiting
Phase 1
A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors
Metastatic Hepatocellular CarcinomaLocal Advanced Hepatocellular CarcinomaAlpha-fetoprotein (AFP)-Producing Gastric Cancer+2 more
BeOne Medicines140 enrolled20 locationsNCT06427941
Recruiting
Phase 1
Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.
Neuromyelitis Optica Spectrum Disorder (NMOSD)Multiple Sclerosis (MS)Myasthenia Gravis (MG)+3 more
Tongji Hospital6 enrolled1 locationNCT07526493
Recruiting
Phase 1Phase 2
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome
Ionis Pharmaceuticals, Inc.48 enrolled11 locationsNCT06430385
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)
Muscular DystrophyLimb Girdle Muscular DystrophyLGMD2I+6 more
AskBio Inc10 enrolled6 locationsNCT05230459
Recruiting
Phase 1
A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK
Alzheimer DiseaseAutosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder)Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder)+1 more
University College, London10 enrolled2 locationsNCT06372821
Recruiting
Phase 1
HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma
Soft Tissue SarcomaSarcomaOsteosarcoma+5 more
Baylor College of Medicine25 enrolled1 locationNCT04995003
Recruiting
Phase 1Phase 2
A Study of SRSD216 in Patients With Elevated Lipoprotein (a)
Hyperlipoproteinemia (a)
Sirius Therapeutics Co., Ltd.84 enrolled1 locationNCT07172646
Recruiting
Phase 1Phase 2
Safety and Efficacy of PMT Therapy of hPAP
Hereditary Pulmonary Alveolar Proteinosis
Children's Hospital Medical Center, Cincinnati3 enrolled1 locationNCT05761899
Recruiting
Phase 1Phase 2
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Breast CancerEsophageal CancerGastric Cancer+13 more
Tanabe Pharma America, Inc.27 enrolled6 locationsNCT06943521
Recruiting
Phase 1Phase 2
Peptide Vaccine To Prevent Acquired Resistance In Patients With Advanced ALK+ NSCLC
NSCLC Stage IVALK Fusion Protein Expression
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins12 enrolled1 locationNCT05950139
Recruiting
Phase 1
Phase I Study of JYP0322 in ROS1 Fusion-Positive Solid Tumors
Lung NeoplasmsBrain NeoplasmsProtein Kinase Inhibitors+1 more
Guangzhou JOYO Pharma Co., Ltd101 enrolled1 locationNCT06128148
Recruiting
Phase 1
A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases
Myasthenia GravisMultiple Sclerosis (MS)Neuromyelitis Optica Spectrum Disease (NMOSD)+1 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology37 enrolled3 locationsNCT06869278
Recruiting
Phase 1
PRE-I-SPY Phase I/Ib Oncology Platform Program
Metastatic Breast CancerHER2-negative Breast CancerMetastatic Cancer+5 more
QuantumLeap Healthcare Collaborative124 enrolled7 locationsNCT05868226
Recruiting
Phase 1
Impact of Recombinant Humanized Type III Collagen on the Immediate and Long-term Effects of Breast Tumor Surgery
Breast CancerCollagen Protein
Peking University People's Hospital30 enrolled1 locationNCT06725082
Recruiting
Phase 1
A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study
NeoplasmsMultiple MyelomaCardiovascular Diseases+11 more
OriCell Therapeutics Co., Ltd.81 enrolled1 locationNCT06271252
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma
NeoplasmsMultiple MyelomaParaproteinemias+5 more
Hellenic Society of Hematology36 enrolled2 locationsNCT05573802
Not Yet Recruiting
Phase 1
A Safety and Tolerability Study Evaluating CTX320 in Subjects With Elevated Lipoprotein(a) and a History of Atherosclerotic Cardiovascular Disease or Calcific Aortic Valve Stenosis.
Elevated Lipoprotein(a)Atherosclerotic Cardiovascular DiseaseCalcific Aortic Valve Stenosis
CRISPR Therapeutics AG24 enrolled1 locationACTRN12623001095651
Completed
Phase 1
A Study to Evaluate BW-00112 in Adult Subjects
Elevated Low-density lipoprotein cholesterol
ARGO BIOPHARMA AUSTRALIA PTY LTD32 enrolled1 locationACTRN12622001429741
Not Yet Recruiting
Phase 1
A Phase 1, Partially Blinded, Placebo-Controlled, Pharmacokinetic Study of Intravenously Administered BMS-943539-01-001 in Healthy Male Volunteers
Pharmacokinetics of Intravenously Administered BMS-943539 in Healthy Male Volunteers.
BMS-943539 is an Adnectin (protein) which is specifically engineered to bind to Human Serum Albumin (HSA).
Bristol-Myers Squibb Australia37 enrolled1 locationACTRN12610001043022