A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases

This study is testing a new type of immune cell therapy called LCAR-AIO CAR-T cell therapy for people with severe, treatment-resistant neurological autoimmune diseases — conditions where the immune system attacks the nervous system. **You may be eligible if...** - You are between 18 and 70 years old - You have been diagnosed with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody disease (MOGAD), or myasthenia gravis (MG) for at least 6 months - Your disease has relapsed or not responded to standard treatments - Your disease is confirmed by specific blood antibody tests (such as AQP4-IgG, MOG-IgG, AChR-IgG, or MuSK-IgG) - Your organ function is within acceptable ranges **You may NOT be eligible if...** - You have active infections like hepatitis or tuberculosis - You have other autoimmune diseases - You have a serious condition like cancer, uncontrolled diabetes, or significant heart disease - You are pregnant, breastfeeding, or planning to become pregnant Talk to your doctor to see if this trial is right for you.