Rheumatic disease Clinical Trials

25 recruitingLast updated: May 13, 2026

There are 25 actively recruiting rheumatic disease clinical trials across 26 countries. Studies span Not Applicable, Phase 4, Early Phase 1, Phase 2, Phase 3. Top locations include Milan, Italy, New York, New York, United States, Bethesda, Maryland, United States. Updated daily from ClinicalTrials.gov.


Rheumatic disease Trials at a Glance

25 actively recruiting trials for rheumatic disease are listed on ClinicalTrialsFinder across 6 cities in 26 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Milan, New York, and Bethesda. Lead sponsors running rheumatic disease studies include IRCCS San Raffaele, McGill University Health Centre/Research Institute of the McGill University Health Centre, and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

Browse rheumatic disease trials by phase

Treatments under study

About Rheumatic disease Clinical Trials

Looking for clinical trials for Rheumatic disease? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Rheumatic disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Rheumatic disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 25 trials

Recruiting

Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease

Rheumatic disease
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)350 enrolled1 locationNCT02504879
Recruiting
Phase 2

A Study of SPY072 in Rheumatic Disease

Rheumatoid ArthritisPsoriatic ArthritisRheumatic Diseases+5 more
Spyre Therapeutics, Inc.285 enrolled64 locationsNCT07148414
Recruiting

Studies of the Natural History of Rheumatic Diseases

ArthritisRheumatic Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)7,500 enrolled1 locationNCT00024479
Recruiting
Phase 3

A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases

Interstitial Lung DiseasesSystemic Autoimmune Rheumatic Diseases Associated Interstitial Lung Diseases
Boehringer Ingelheim400 enrolled158 locationsNCT06806592
Recruiting

The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions

VasculitisSystemic Lupus Erthematosus (SLE)Rheumatic Diseases+3 more
McGill University Health Centre/Research Institute of the McGill University Health Centre100 enrolled1 locationNCT07278609
Recruiting

Compassionate Care and Organization of Healthcare Services for a Successful Transition in Rheumatology

Chronic Inflammatory Rheumatic Diseases of ChildhoodJuvenile-Onset Chronic Inflammatory Rheumatic DiseasesTransition of Care in Chronic Inflammatory Rheumatic Diseases
Assistance Publique - Hôpitaux de Paris50 enrolled1 locationNCT07469787
Recruiting
Early Phase 1

Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases

Systemic Lupus Erythematosus (SLE)Rheumatic DiseasesPediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)+1 more
The Children's Hospital of Zhejiang University School of Medicine36 enrolled1 locationNCT07490041
Recruiting
Phase 4

Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases Under Immunomodulators

Autoimmune Rheumatic Diseases
University of Sao Paulo General Hospital200 enrolled1 locationNCT07280741
Recruiting

Rheumatology Patient Registry and Biorepository

Rheumatoid ArthritisLyme DiseaseSarcoidosis+17 more
Yale University5,000 enrolled1 locationNCT04402086
Recruiting

Exploring and Measuring the Impact of Steroids in Children and Young People

Rheumatic DiseasesRheumatic DisorderRheumatologic Conditions (JRA,Lupus)
University of the West of England70 enrolled3 locationsNCT07350395
Recruiting

Dynamic Gait Index as a Functional Gait Assessment Measure in Children With JIA

Juvenile Idiopathic ArthritisChildhood Rheumatic Disease
Istanbul University - Cerrahpasa52 enrolled1 locationNCT06870045
Recruiting

Investigation of Catastrophizing of Pain Reported by Parents in JIA Patients

Juvenile Idiopathic Arthritis (JIA)Childhood Rheumatic Diseases
Hacettepe University50 enrolled1 locationNCT07185750
Recruiting

Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy

Psoriatic Arthritis (PsA)Rheumatoid Arthritis (RA)Systemic Sclerosis (SSc)+10 more
University of Bonn120 enrolled1 locationNCT07150000
Recruiting

Autoimmune and Autoinflammatory Genetics Study

Rheumatic diseaseAutoimmune DiseaseAutoinflammatory Disease+1 more
NYU Langone Health1,500 enrolled2 locationsNCT06004349
Recruiting
Not Applicable

Evaluation of Mood Disorders Under Biologics in Chronic Inflammatory Rheumatic Disease

Mood DisordersRheumatic Diseases
Centre Hospitalier Universitaire de Besancon108 enrolled1 locationNCT04817072
Recruiting

Medically Assisted Fertilization Techniques in Systemic Immunoreumatologic Diseases

Pregnancy ComplicationsFertility DisordersPregnancy, High Risk+2 more
IRCCS San Raffaele500 enrolled1 locationNCT05807256
Recruiting

Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome

Pregnancy ComplicationsPreeclampsiaPregnancy, High Risk+3 more
IRCCS San Raffaele60 enrolled1 locationNCT05786235
Recruiting

Observational Pharmaco-Epidemiology Research & Analysis

Cardiovascular DiseasesInflammatory Bowel DiseasesLiver Diseases+4 more
Epividian2,000,000 enrolled1 locationNCT03813862
Recruiting
Not Applicable

tDCS in Post-Acute COVID-19 Patients With SARDs

Autoimmune DiseasesRheumatic Diseases
University of Sao Paulo20 enrolled1 locationNCT04890483
Recruiting
Not Applicable

Evaluation of Cognitive Behavioral Therapy for Long-term Pain in Rheumatic Disease, Including Validation of AE-FS

Pain, ChronicRheumatic Diseases
Diakonhjemmet Hospital200 enrolled1 locationNCT06413914