Phase 1 Safety Clinical Trials
35 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 35 trials
Recruiting
Phase 1
A First in Human Study of the Safety, Tolerability, and the Physiologically Based Pharmacokinetics of XFB19 in Healthy Adult Volunteers.
Focus of the Study: Safety of XFB19
Xfibra, Inc.40 enrolled1 locationNCT05361733
Recruiting
Phase 1
A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD)
SafetyTolerabilityAdult Growth Hormone Deficiency
Changchun GeneScience Pharmaceutical Co., Ltd.64 enrolled1 locationNCT07016802
Recruiting
Phase 1
Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage Cancer
SafetyDemoralization
Gustavo Vazquez15 enrolled1 locationNCT06818994
Recruiting
Phase 1
Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease
First in Man Study to Evaluate Initial Safety
Gliknik Inc.70 enrolled1 locationNCT05318534
Recruiting
Phase 1Phase 2
Safety and Tolerability of IRL757 in Participants With Parkinson's Disease and Apathy
SafetyPARKINSON DISEASE (Disorder)Apathy
Integrative Research Laboratories AB75 enrolled13 locationsNCT07461220
Recruiting
Phase 1
Safety, Tolerability, PK and PD of SSS55 in Healthy Subjects
Safety Issues
Shenyang Sunshine Pharmaceutical Co., LTD.26 enrolled1 locationNCT07058779
Recruiting
Phase 1
A Study of GensSci098 in Subjects With Graves' Disease
SafetyGraves DiseaseTolerability+1 more
Changchun GeneScience Pharmaceutical Co., Ltd.24 enrolled1 locationNCT07286656
Recruiting
Phase 1
A Study of GenSci098 in Subjects With Active Thyroid Eye Disease
SafetyTolerabilityGenSci098+1 more
Changchun GeneScience Pharmaceutical Co., Ltd.76 enrolled1 locationNCT06569758
Recruiting
Phase 1
Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders
Temporal Interference StimulationHealth AdultsSafety and Effectiveness+1 more
Taipei Veterans General Hospital, Taiwan80 enrolled1 locationNCT07179848
Recruiting
Phase 1
A Safety Study of IVMED-85 Ophthalmic Solution in Healthy Adults
Safety Study
iVeena Delivery Systems, Inc.36 enrolled1 locationNCT07370584
Recruiting
Phase 1Phase 2
Phase 1/2 Study of HYP-2090PTSA in Patients With Advanced Solid Tumors Harboring KRAS Mutation
EfficacySafetyTolerability
Sichuan Huiyu Pharmaceutical Co., Ltd257 enrolled6 locationsNCT06243354
Recruiting
Phase 1Phase 2
Phase 1/2 Clinical Study of HY07121 Powder for Solution for Infusion in Patients With Advanced Solid Tumors
EfficacySafetyTolerability
Sichuan Huiyu Pharmaceutical Co., Ltd258 enrolled1 locationNCT06639256
Recruiting
Phase 1Phase 2
Curcumin and Retinal Study
SafetyGut MicrobiomeBioavailability
Texas Tech University Health Sciences Center60 enrolled1 locationNCT05774704
Recruiting
Phase 1
Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination
Healthy VolunteerSafetyPharmacokinetics+2 more
Basilea Pharmaceutica46 enrolled1 locationNCT06733675
Recruiting
Phase 1
Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
EfficacySafetySpinal Cord Injury+4 more
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT06976229
Recruiting
Phase 1
Safety, Tolerability, and Pharmacokinetics of RCS-21 in Healthy Volunteers.
SafetyHealthy VolunteersTolerability+1 more
RNATICS GmbH24 enrolled1 locationNCT06752122
Recruiting
Phase 1
Single Ascending Dose and Multiple Ascending Dose Evaluation of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MDI-2517 in Healthy Participants
Safety After Oral Intake
MDI Therapeutics, Inc.52 enrolled1 locationNCT07220889
Recruiting
Phase 1Phase 2
Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors
Safety IssuesTolerabilityPharmacokinetics
Nanjing Immunophage Biotech Co., Ltd196 enrolled7 locationsNCT05142592
Recruiting
Phase 1Phase 2
Evaluation of Clinical, Perceived and Instrumental Efficacy of a Scar Gel in Preventing Hypertrophic Scars
Safety and EfficacyTopical AdministrationAcceptability Study+1 more
Herbarium Laboratorio Botanico Ltda80 enrolled2 locationsNCT06751433
Recruiting
Phase 1
Intracoronary Administration of OmniMSC-AMI for Acute ST-segment Elevation Myocardial Infarction Patients
Safety Issues
Taiwan Bio Therapeutics Inc.10 enrolled1 locationNCT05724576