RecruitingPhase 1Phase 2NCT05774704
Curcumin and Retinal Study
Curcumin and Retinal Amyloid-beta Pilot Study
Sponsor
Texas Tech University Health Sciences Center
Enrollment
60 participants
Start Date
Aug 21, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
To test how two weeks of curcumin supplementation would cross the blood brain barrier (BBB) and attach to amyloid beta proteins, to assess the feasibility (safety and bioavailability), and to explore the resulting abundance/composition of gut microbiota.
Eligibility
Min Age: 40 YearsMax Age: 89 Years
Inclusion Criteria3
- Both male and female, age 40 - 89 years.
- Diagnosed with Aβ deposits in retina (peripheral superior quadrants)--to be confirmed after consent obtained. If there is documentation the potential participant has been diagnosed with Aβ deposits in retina within 6 months before the consent session, we will use this diagnosis/documentation for eligibility criteria. Otherwise, the ophthalmic exam will be repeated after consent is obtained for the study.
- No pre-existing liver or kidney diseases by self-report.
Exclusion Criteria5
- Patients with ocular diseases (macular degeneration, severe diabetes retinopathy)
- Had used systemic antibiotics within 1 month prior to the start of the study intervention
- Had taken any turmeric or curcumin products within 2 weeks prior to the start of the study intervention
- Had a known allergy to black pepper
- Women that are pregnant or breastfeeding
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGLow curcumin group
One curcumin capsule (250 mg curcumin) after each meal, 3 times a day for 2 weeks.
DRUGHigh curcumin group
One curcumin capsule (500 mg curcumin) after each meal, 3 times a day for 2 weeks.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05774704
Related Trials
Goat Milk-Derived Formula vs. Undiluted Goat Milk in Infants Unable to Exclusively Breastfeed: Growth and Biomarker Analysis
NCT072251531 location
Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure
NCT067355991 location
Microbiome and Diet in Parkinson's Disease
NCT062071361 location
Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men
NCT074815781 location
Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage Cancer
NCT068189941 location