Sarcoma,Soft Tissue Clinical Trials

24 recruitingLast updated: June 17, 2026

There are 24 actively recruiting sarcoma,soft tissue clinical trials across 16 countries. Studies span Phase 2, Phase 1, Not Applicable, Early Phase 1. Top locations include Madrid, Spain, Barcelona, Spain, Erlangen, Germany. Updated daily from ClinicalTrials.gov.


Sarcoma,Soft Tissue Trials at a Glance

24 actively recruiting trials for sarcoma,soft tissue are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Phase 2 with 13 trials, with the heaviest enrollment activity in Madrid, Barcelona, and Erlangen. Lead sponsors running sarcoma,soft tissue studies include Grupo Espanol de Investigacion en Sarcomas, EpicentRx, Inc., and Cancer Institute and Hospital, Chinese Academy of Medical Sciences.

Browse sarcoma,soft tissue trials by phase

Treatments under study

About Sarcoma,Soft Tissue Clinical Trials

Looking for clinical trials for Sarcoma,Soft Tissue? There are currently 24 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Sarcoma,Soft Tissue trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Sarcoma,Soft Tissue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 24 trials

Recruiting
Phase 2

Preoperative IMRT With Anlotinib and Penpulimab for Localized Sarcoma (SPARE-01)

Sarcoma,Soft TissueAnlotinibIntensity Modulated Radiotherapy+3 more
Cancer Institute and Hospital, Chinese Academy of Medical Sciences30 enrolled1 locationNCT05167994
Recruiting

Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients

Gait disorderSarcoma,Soft TissueSarcoma, Bone
St. Jude Children's Research Hospital300 enrolled1 locationNCT07502885
Recruiting
Phase 2

Pemetrexed, Cisplatin With Soft Tissue Sarcoma

Sarcoma,Soft Tissue
Yonsei University164 enrolled1 locationNCT04605770
Recruiting
Phase 1Phase 2

Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

Soft Tissue SarcomaSarcomaSarcoma,Soft Tissue+1 more
Memorial Sloan Kettering Cancer Center98 enrolled1 locationNCT04577014
Recruiting

The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)

Sarcoma,Soft TissueEpithelioid Hemangioendothelioma
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano100 enrolled22 locationsNCT06408441
Recruiting
Not Applicable

Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion

Sarcoma,Soft Tissue
University Hospital Heidelberg64 enrolled1 locationNCT04219202
Recruiting
Phase 2

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Sarcoma,Soft TissueSarcoma Metastatic
Wake Forest University Health Sciences50 enrolled2 locationsNCT07291297
Recruiting
Not Applicable

Short Course of Radiotherapy Prior to Surgery of Soft Tissue Sarcomas

SarcomaSarcoma,Soft TissueSarcoma of Soft Tissue
The Netherlands Cancer Institute150 enrolled6 locationsNCT07071727
Recruiting

GISAR German Interdisciplinary Sarcoma Registry

SarcomaSarcoma,Soft TissueSarcoma of Bone+1 more
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest9,000 enrolled21 locationsNCT04122872
Recruiting
Phase 2

Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma (TNT-HYPE)

Sarcoma,Soft Tissue
Swiss Cancer Institute24 enrolled8 locationsNCT06835049
Recruiting

Colorectal Resections in Patients With Retroperitoneal Sarcoma

Sarcoma,Soft TissueRetroperitoneal Sarcoma
Heidelberg University120 enrolled13 locationsNCT06943612
Recruiting
Not Applicable

Preventive Application of Single-use Negative Pressure Wound Therapy (sNPWT) in the Postoperative Course of Radiotreatated Limb Sarcoma Surgery

SarcomaSarcoma,Soft Tissue
Istituto Oncologico Veneto IRCCS48 enrolled1 locationNCT06941194
Recruiting
Phase 1Phase 2

Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic Cancers

Triple-Negative Breast CancerNon-small Cell Lung CancerMetastatic Cancer+6 more
Hadassah Medical Organization3 enrolled1 locationNCT05296564
Recruiting
Phase 1Phase 2

Sequential Infusion of CD146-Targeted and HER2-Targeted CAR T Cells in Patients With Advanced Sarcomas

SarcomaSarcoma, SynovialSarcoma,Soft Tissue+6 more
Essen Biotech60 enrolled1 locationNCT07066982
Recruiting
Phase 2

Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma (SeliSarc)

Sarcoma,Soft Tissue
Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas88 enrolled11 locationsNCT06114004
Recruiting
Phase 2

Brachytherapy (Iodine-125 Seeds) and Fluzoparib Combination Therapy for Advanced Unresectable Soft Tissue Sarcoma

Sarcoma,Soft TissueBrachytherapyPoly(ADP-ribose) Polymerase Inhibitors
Fujun Zhang32 enrolled1 locationNCT05894018
Recruiting
Not Applicable

Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life

Sarcoma,Soft Tissue
Fondazione Policlinico Universitario Campus Bio-Medico120 enrolled3 locationsNCT06873685
Recruiting
Phase 2

A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors

SarcomaCancerSolid Tumor, Adult+3 more
EpicentRx, Inc.140 enrolled6 locationsNCT04673942
Recruiting
Phase 2

Phase II Clinical Trial of Chidamide Combined With AK112 for Second-line and Advanced Bone and Soft Tissue Sarcoma

SarcomaSarcoma,Soft TissueSarcoma of Bone
Shanxi Province Cancer Hospital30 enrolled1 locationNCT06637007
Recruiting
Phase 1

Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma and Osteosarcoma

Sarcoma,Soft Tissue
Grupo Espanol de Investigacion en Sarcomas14 enrolled6 locationsNCT04595994