Severe Brain Injury Clinical Trials

8 recruitingLast updated: May 13, 2026

There are 8 actively recruiting severe brain injury clinical trials across 5 countries. Studies span Not Applicable. Top locations include Boston, Massachusetts, United States, Charlestown, Massachusetts, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Severe Brain Injury Trials at a Glance

8 actively recruiting trials for severe brain injury are listed on ClinicalTrialsFinder across 6 cities in 5 countries. The largest study group is Not Applicable with 4 trials, with the heaviest enrollment activity in Boston, Charlestown, and Dallas. Lead sponsors running severe brain injury studies include Centre Hospitalier St Anne, Fondazione Don Carlo Gnocchi Onlus, and BDH-Klinik Hessisch Oldendorf.

Browse severe brain injury trials by phase

About Severe Brain Injury Clinical Trials

Looking for clinical trials for Severe Brain Injury? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Severe Brain Injury trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Severe Brain Injury clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 18 of 8 trials

Recruiting

Assessment of Consciousness With CRS-R and SECONDs

Disorders of Consciousness Due to Severe Brain InjuryMinimally Conscious StateUnresponsive Wakefulness Syndrome
BDH-Klinik Hessisch Oldendorf110 enrolled1 locationNCT07456020
Recruiting
Not Applicable

Promoting Recovery After Brain Injury Using Focused Ultrasound

Consciousness DisordersDisorders of Consciousness Due to Severe Brain Injury
Massachusetts General Hospital36 enrolled2 locationsNCT07277309
Recruiting

Effect of the Stellate Ganglion Block on the Retinal Microcirculation

Severe Brain InjurySubarachnoid HemorrhageIntracerebral Hemorrhage+1 more
University of Texas Southwestern Medical Center50 enrolled1 locationNCT06797752
Recruiting
Not Applicable

Ultrasound Stimulation for Patients in a Disorder of Consciousness

Consciousness DisordersDisorders of Consciousness Due to Severe Brain Injury
University of California, Los Angeles60 enrolled4 locationsNCT06939348
Recruiting
Not Applicable

Consciousness Prognosis Evaluation Using Olfactory Stimulations in Comatose Patients)

Disorders of Consciousness Due to Severe Brain Injury
Centre Hospitalier St Anne96 enrolled1 locationNCT07127224
Recruiting
Not Applicable

Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness

Severe Brain InjuryDisorders of ConsciousnessMinimally Conscious State+1 more
Xijing Hospital10 enrolled2 locationsNCT06851156
Recruiting

Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury

StrokeRehabilitationVascular Severe Brain Injury
Fondazione Don Carlo Gnocchi Onlus60 enrolled3 locationsNCT06871800
Recruiting

Observational Study on Energy Expenditure and Protein Metabolism Changes in Patients With Severe Brain Injury.

Energy Metabolism and Muscle Mass Changes in Patients With Severe Brain Injury
Southeast University, China6 enrolled1 locationNCT06577402