SHOULDER ARTHROPLASTY Clinical Trials

18 recruitingLast updated: June 18, 2026

There are 18 actively recruiting shoulder arthroplasty clinical trials across 9 countries. Studies span Not Applicable, Phase 4, Phase 3. Top locations include Denver, Colorado, United States, New York, New York, United States, Charlottesville, Virginia, United States. Updated daily from ClinicalTrials.gov.


SHOULDER ARTHROPLASTY Trials at a Glance

18 actively recruiting trials for shoulder arthroplasty are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Denver, New York, and Charlottesville. Lead sponsors running shoulder arthroplasty studies include Claudio Pedone, Emory University, and Arthrex, Inc..

Browse shoulder arthroplasty trials by phase

Treatments under study

About SHOULDER ARTHROPLASTY Clinical Trials

Looking for clinical trials for SHOULDER ARTHROPLASTY? There are currently 8 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new SHOULDER ARTHROPLASTY trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about SHOULDER ARTHROPLASTY clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 118 of 18 trials

Recruiting
Not Applicable

Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture

Orthopedic DisorderHumerus fractureSHOULDER ARTHROPLASTY+1 more
University of Virginia10 enrolled1 locationNCT06869343
Recruiting

Shoulder Innovations Clinical Data Registry

SHOULDER ARTHROPLASTY
Shoulder Innovations2,500 enrolled8 locationsNCT06754150
Recruiting
Phase 3

Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty

SHOULDER ARTHROPLASTY
University of Alabama at Birmingham60 enrolled1 locationNCT06902714
Recruiting
Not Applicable

Innovating Physical Therapy: A Pilot Study on Band Connect's Impact on Compliance, Satisfaction, and Revenue

Rotator Cuff TearsReverse Total Shoulder ArthroplastyAnatomic Total Shoulder Arthroplasty
University Hospitals Cleveland Medical Center499 enrolled1 locationNCT06733480
Recruiting
Phase 4

Addition of a Pectoserratus Block to Interscalene Block in Patients Undergoing Total Shoulder Replacement

Total Shoulder Arthroplasty
University of Minnesota110 enrolled1 locationNCT06143306
Recruiting
Not Applicable

Strengthening Exercises for Humeral Head Depressor Muscles

Reverse Shoulder ArthroplastyDepressor Muscle TrainingShoulder Rehabilitation
Hacettepe University27 enrolled1 locationNCT07309796
Recruiting

Hospital for Special Surgery Shoulder Arthroplasty Cohort

SHOULDER ARTHROPLASTY
Hospital for Special Surgery, New York250 enrolled2 locationsNCT00527839
Recruiting

Does Undergoing a Prehabilitation Protocol Aimed at Optimizing Scapulothoracic Mobility and Strengthening Improve Internal Rotation After Reverse Shoulder Arthroplasty?

Primary Reverse Total Shoulder Arthroplasty
University of Florida64 enrolled1 locationNCT07145957
Recruiting
Not Applicable

Role of Nutritional Status in Functional Recovery of Older Adults Undergoing Virtual Reality-augmented Shoulder Rehabilitation (VIR)

Virtual RealityRehabilitationSHOULDER ARTHROPLASTY+1 more
Claudio Pedone60 enrolled1 locationNCT07282561
Recruiting
Not Applicable

Pectoralis Minor Release Versus Non-release in RSA

Rotator Cuff Tear ArthropathyReverse Total Shoulder ArthroplastyAdvanced Glenohumeral Osteoarthritis
Emory University90 enrolled2 locationsNCT06292169
Recruiting

Clinical and Radiological Outcomes of Medacta Shoulder System FR

FractureRheumatoid Arthritis ShoulderPrimary Osteoarthritis+4 more
Medacta International SA200 enrolled1 locationNCT05926622
Recruiting
Phase 4

Effects on Postoperative Pain of Liposomal Bupivacaine in Interscalene Blocks for Total Shoulder Arthroplasty Patients

Total Shoulder ArthroplastyReverse Total Shoulder Arthroplasty
Johnny K. Lee120 enrolled1 locationNCT05900427
Recruiting

Total Shoulder Arthroplasty Multi-Center Registry

SHOULDER ARTHROPLASTY
Arthrex, Inc.2,500 enrolled24 locationsNCT03511586
Recruiting
Not Applicable

At Home, Digital Rehabilitation for Patients After Reverse Total Shoulder Arthroplasty

Reverse Total Shoulder ArthroplastyArthroplasty, Replacement, Shoulder
Samsung Medical Center100 enrolled1 locationNCT06891378
Recruiting
Not Applicable

Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty

SHOULDER ARTHROPLASTYPositive C. Acnes Culture
Henry Ford Health System150 enrolled1 locationNCT06831422
Recruiting

Duration of Immobilization After Reverse Total Arthroplasty for Proximal Humerus Fractures

Reverse Total Shoulder ArthroplastyProximal Humeral Fracture
The Cooper Health System40 enrolled1 locationNCT06133920
Recruiting
Not Applicable

Shoulder Prosthesis Telerehab Care Trial

TelerehabilitationRehabilitationSHOULDER ARTHROPLASTY
University Hospital, Ghent120 enrolled1 locationNCT05699031
Recruiting
Phase 4

The efficacy of topical preparations in reducing the incidence of P. Acnes in total shoulder arthroplasty

Total Shoulder ArthroplastyShoulder Osteoarthritis
Orthopaedic Research Institute Queensland105 enrolled1 locationACTRN12618000261213