Phase 2 Sickle Cell Clinical Trials
44 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 44 trials
Recruiting
Phase 2
Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease
Sickle Cell Disease
St. Jude Children's Research Hospital45 enrolled1 locationNCT07616154
Recruiting
Phase 1Phase 2
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Sickle Cell Disease
Novartis Pharmaceuticals161 enrolled9 locationsNCT06546670
Recruiting
Phase 2
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
Sickle Cell DiseaseOsteonecrosisAvascular Necrosis+2 more
University of California, Davis30 enrolled1 locationNCT06016634
Recruiting
Phase 2
Tocilizumab for Acute Chest Syndrome
Sickle Cell DiseaseAcute Chest Syndrome
University of Chicago200 enrolled1 locationNCT05640271
Recruiting
Phase 1Phase 2
Optimizing Hydroxyurea Therapy in Children With Sickle Cell Anemia In Malaria Endemic Areas: The NOHARM Maximum Tolerated Dose (MTD) Study
Sickle Cell DiseaseSickle Cell Anemia in Children
Children's Hospital Medical Center, Cincinnati250 enrolled1 locationNCT07708714
Recruiting
Phase 1Phase 2
Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
Beta-ThalassemiaSickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)90 enrolled1 locationNCT07599176
Recruiting
Phase 2
Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease
Sickle Cell Disease
University of Illinois at Chicago50 enrolled1 locationNCT03121001
Recruiting
Phase 1Phase 2
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
Diamond-Blackfan AnemiaSickle Cell Anemiabeta thalassemia major
Paul Szabolcs5 enrolled1 locationNCT03653338
Recruiting
Phase 1Phase 2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Healthy VolunteersAnemia, Sickle Cell
Bristol-Myers Squibb224 enrolled33 locationsNCT06481306
Recruiting
Phase 1Phase 2
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
Sickle Cell Disease
Kamau Therapeutics15 enrolled6 locationsNCT04819841
Recruiting
Phase 2
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)
Sickle Cell DiseaseThalassemiaThalassemia (beta)
Memorial Sloan Kettering Cancer Center24 enrolled6 locationsNCT05736419
Recruiting
Phase 1Phase 2
Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
Sickle Cell DiseaseGraft FailureHematopoetic Stem Cell Transplant+2 more
Arkansas Children's Hospital Research Institute24 enrolled4 locationsNCT07252050
Recruiting
Phase 2
Allo HSCT for High Risk Hemoglobinopathies
Sickle Cell DiseaseHemoglobinopathiesGraft Failure
Masonic Cancer Center, University of Minnesota62 enrolled1 locationNCT06872333
Recruiting
Phase 1Phase 2
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
HemoglobinopathiesBone Marrow Failure SyndromesMetabolic Disorders+3 more
Washington University School of Medicine29 enrolled4 locationsNCT03128996
Recruiting
Phase 2
Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin
AlbuminuriaSickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
University of Illinois at Chicago20 enrolled1 locationNCT07175051
Recruiting
Phase 2
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
Sickle Cell Disease Vaso-occlusive Crisis
CSL Behring70 enrolled19 locationsNCT06699849
Recruiting
Phase 2
Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
Sickle Cell Disease
CSL Behring63 enrolled5 locationsNCT07224360
Recruiting
Phase 2
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Sickle Cell Disease
St. Jude Children's Research Hospital40 enrolled1 locationNCT05583721
Recruiting
Phase 2
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor
Sickle Cell DiseaseStem Cell Transplant ComplicationsPure Red Cell Aplasia+1 more
University of Calgary12 enrolled1 locationNCT03214354
Recruiting
Phase 1Phase 2
RH Genotype Matched RBC Transfusions
Sickle Cells Disease
Children's Hospital of Philadelphia35 enrolled1 locationNCT04156893