Phase 1 SpA Clinical Trials
18 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–18 of 18 trials
Recruiting
Phase 1Phase 2
EAST-1 (ERAP-inhibition in Axial Spondyloarthritis Trial - 1)
Axial Spondyloarthritis (AxSpA)
Grey Wolf Therapeutics141 enrolled15 locationsNCT07047703
Recruiting
Phase 1Phase 2
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
Spasticity
Ipsen240 enrolled81 locationsNCT04752774
Recruiting
Phase 1
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Spinal Cord InjurySpasticityShockwave Therapy
Kessler Foundation12 enrolled1 locationNCT07501429
Recruiting
Phase 1
Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies
Genetic epilepsyDevelopmental and Epileptic EncephalopathiesEpileptic Spasms+1 more
Heather Olson10 enrolled1 locationNCT06700811
Not Yet Recruiting
Phase 1
A study in healthy women comparing two topical gels (Mi-Gel® and estriol gel) applied to the vulva twice daily over 6 consecutive days in two seperate applicaton periods.
VestibulitisVulvodyniaDyspareunia
Zenith Technology Corporation Limited34 enrolled1 locationACTRN12625001284459
Not Yet Recruiting
Phase 1
A pivotal study in healthy women comparing Mi-Gel® and amitriptyline gel applied topically for 6 consecutive days.
VestibulitisVulvodyniaDyspareunia
Zenith Technology Corporation Limited24 enrolled1 locationACTRN12625000939493
Completed
Phase 1
A study in healthy women comparing Mi-Gel® and estriol gel applied topically for 6 consecutive days.
VestibulitisVulvodyniaDyspareunia
Zenith Technology Corporation Limited8 enrolled1 locationACTRN12625000393459
Completed
Phase 1
A study in healthy women comparing Mi-Gel® and amitriptyline gel applied topically for 6 consecutive days.
VestibulitisVulvodyniaDyspareunia
Zenith Technology Corporation Limited8 enrolled1 locationACTRN12625000315415
Completed
Phase 1
An Open-label, 2 Part, Study to Assess the Pharmacokinetics of a Spray Dried Dispersion Formulation of Radiprodil Under Fasted and Fed Conditions in Healthy Adult Subjects: Part B
Glutamate receptor ionotropic N-methyl-D-aspartate (GRIN) related disorder - neurodevelopmental syndromes
GRIN Therapeutics, Inc.18 enrolled1 locationACTRN12624001440516
Recruiting
Phase 1
Low or High Botox Dilution for the Hemiplegic Gait?
Post Stroke Spastic Hemiplegia
University of Ioannina20 enrolled1 locationNCT04630873
Completed
Phase 1
An Open-label, 2 Part, Study to Assess the Pharmacokinetics of a Spray Dried Dispersion Formulation of Radiprodil Under Fasted and Fed Conditions in Healthy Adult Subjects: Part A
Glutamate receptor ionotropic N-methyl-D-aspartate (GRIN) related disorder - neurodevelopmental syndromes
GRIN Therapeutics, Inc.18 enrolled1 locationACTRN12624001366549
Recruiting
Phase 1Phase 2
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)
Spasticity, MuscleSpastic ParaplegiaMicrocephaly+3 more
Elpida Therapeutics SPC4 enrolled1 locationNCT05518188
Terminated
Phase 1
Comparative, Multiple-Dose, Fixed Sequence, Pharmacokinetic Study of 2 Sizes of Daily MRX-4TZT TDS (Tizanidine Transdermal Delivery System) Applied for 3 Days and 2 Dose Levels of Oral Tizanidine in Healthy Adult Subjects
Spasticity
MEDRx Australia Pty Ltd24 enrolled1 locationACTRN12624001134516
Completed
Phase 1
A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Assess the Safety and Pharmacokinetics of CHI-541 among Healthy Participants
Muscle SpasticityPainEpilepsy+1 more
10607410 CANADA INC. DBA Spectrum Therapeutics40 enrolled1 locationACTRN12619001723178
Completed
Phase 1
A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Assess the Safety and Pharmacokinetics of CHI-936 in Healthy Participants
Muscle SpasticityPainEpilepsy+1 more
10607410 CANADA INC. DBA Spectrum Therapeutics40 enrolled1 locationACTRN12619001450101
Recruiting
Phase 1
The impact of Sulpiride (600mg; a dopamine antagonist) on behavioural and electrophysiological measures of visuospatial attention and inhibition
Inhibitory Control DeficitsSpatial Attention Deficits
Professor Mark Bellgrove50 enrolled1 locationACTRN12617000652370
Terminated
Phase 1
A trial to evaluate the effect of FLX-787 ODT on Motor Neuron Disease.
Spasticity & cramps in patients with Motor Neuron Disease
Flex Pharma, Inc50 enrolled3 locationsACTRN12616001060437
Completed
Phase 1
A Randomised, Cross-over Study to Evaluate Efficacy and Tolerability of FLX-787 in Patients with Multiple Sclerosis spasticity and spasms/cramps
Spasticity & cramps in patients with MS
Flex Pharma, Inc80 enrolled8 locationsACTRN12616000714482