Stage II Lung Cancer Clinical Trials

2 recruiting

Stage II Lung Cancer Trials at a Glance

18 actively recruiting trials for stage ii lung cancer are listed on ClinicalTrialsFinder across 6 cities in 2 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in Houston, Chicago, and Buffalo. Lead sponsors running stage ii lung cancer studies include Roswell Park Cancer Institute, M.D. Anderson Cancer Center, and Alliance for Clinical Trials in Oncology.

Browse stage ii lung cancer trials by phase

Treatments under study

About Stage II Lung Cancer Clinical Trials

Looking for clinical trials for Stage II Lung Cancer? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Stage II Lung Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Stage II Lung Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 118 of 18 trials

Recruiting
Phase 3

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Lung Non-Small Cell Carcinoma+3 more
National Cancer Institute (NCI)1,210 enrolled1149 locationsNCT04267848
Recruiting
Phase 3

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Lung Non-Small Cell Carcinoma+1 more
National Cancer Institute (NCI)306 enrolled227 locationsNCT06498635
Recruiting
Phase 2

Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial

Lung CarcinomaStage III Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8+10 more
M.D. Anderson Cancer Center50 enrolled1 locationNCT04789681
Recruiting
Not Applicable

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

Esophageal CarcinomaStage III Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8+14 more
M.D. Anderson Cancer Center400 enrolled1 locationNCT03948100
Recruiting
Not Applicable

Avecure Flexible Microwave Ablation Probe For Lung Nodules

Lung CancerLung Cancer Stage ILung Cancer Stage II+3 more
Beth Israel Deaconess Medical Center10 enrolled1 locationNCT05281237
Recruiting
Phase 3

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Resectable Lung Non-Small Cell Carcinoma+1 more
Alliance for Clinical Trials in Oncology1,100 enrolled377 locationsNCT06632327
Recruiting

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Head and Neck CarcinomaMalignant Solid NeoplasmSarcoma+59 more
Alliance for Clinical Trials in Oncology2,000 enrolled745 locationsNCT05334069
Recruiting
Not Applicable

New York Better Breathing Study

Stage III Lung Cancer AJCC v8Stage II Lung Cancer AJCC v8Localized Lung Carcinoma+1 more
Roswell Park Cancer Institute100 enrolled1 locationNCT06869447
Recruiting
Phase 1

Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer

Malignant Solid NeoplasmClinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8+41 more
M.D. Anderson Cancer Center800 enrolled1 locationNCT03819296
Recruiting
Not Applicable

A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer

Stage III Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8Lung Non-Small Cell Carcinoma+1 more
Mayo Clinic100 enrolled1 locationNCT06122064
Recruiting
Phase 2

Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer

Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Lung Non-Small Cell Carcinoma+2 more
Mayo Clinic60 enrolled1 locationNCT06918132
Recruiting
Not Applicable

Cryodevitalization for the Treatment of Early Stage Lung Cancer, CRYSTAL Trial

Stage I Lung CancerStage II Lung Cancer
Vanderbilt-Ingram Cancer Center30 enrolled1 locationNCT06593106
Recruiting
Not Applicable

Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell CarcinomaMetastatic Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8+10 more
Rutgers, The State University of New Jersey34 enrolled2 locationsNCT04751747
Recruiting
Not Applicable

The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer

Stage III Lung Cancer AJCC v8Lung Non-Small Cell CarcinomaStage II Lung Cancer AJCC v8+1 more
Thomas Jefferson University100 enrolled4 locationsNCT05502523
Recruiting
Not Applicable

Quality of Life Intervention to Inform Patient Decision-Making in Early-Stage Lung Cancer

Lung Non-Small Cell CarcinomaStage II Lung Cancer AJCC v8Stage IIB Lung Cancer AJCC v8+6 more
Roswell Park Cancer Institute150 enrolled1 locationNCT05292521
Recruiting
Not Applicable

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

Lung CarcinomaStage IIIA Lung Cancer AJCC v8Lung Non-Small Cell Carcinoma+3 more
Northwestern University70 enrolled1 locationNCT05802186
Recruiting
Phase 2

Respiratory Muscle Training Before Surgery in Preventing Lung Complications in Patients With Stage I-IIIB Lung Cancer

Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Stage II Lung Cancer AJCC v8+7 more
Roswell Park Cancer Institute220 enrolled1 locationNCT04067830
Recruiting
Phase 1

Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8+6 more
Ohio State University Comprehensive Cancer Center28 enrolled2 locationsNCT05136846