Lung Cancer Stage I Clinical Trials

28 recruitingLast updated: June 18, 2026

There are 28 actively recruiting lung cancer stage i clinical trials across 16 countries. Studies span Phase 2, Not Applicable, Phase 1, Early Phase 1, Phase 3. Top locations include New York, New York, United States, Montvale, New Jersey, United States, Harrison, New York, United States. Updated daily from ClinicalTrials.gov.


Lung Cancer Stage I Trials at a Glance

28 actively recruiting trials for lung cancer stage i are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Phase 2 with 15 trials, with the heaviest enrollment activity in New York, Montvale, and Harrison. Lead sponsors running lung cancer stage i studies include Memorial Sloan Kettering Cancer Center, Sun Yat-sen University, and Wake Forest University Health Sciences.

Browse lung cancer stage i trials by phase

Treatments under study

About Lung Cancer Stage I Clinical Trials

Looking for clinical trials for Lung Cancer Stage I? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Lung Cancer Stage I trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Lung Cancer Stage I clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 28 trials

Recruiting
Phase 2

Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer

Non-small Cell Lung CancerMetastatic Squamous Non-Small Cell Lung CarcinomaNon-Small Cell Lung Cancer (Stage III)+5 more
Genelux Corporation142 enrolled15 locationsNCT06463665
Recruiting

A Registry for People With Lung Cancer

Lung CancerLung Cancer Stage I
Memorial Sloan Kettering Cancer Center600 enrolled17 locationsNCT06424327
Recruiting
Phase 2

Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare Mutations.

MutationLung Cancer Stage III
Sun Yat-sen University120 enrolled1 locationNCT06563999
Recruiting
Phase 2

Neoadjuvant IBI308, Bevacizumab, Plus Pemetrexed and Carboplatin Followed by Surgery in Unresectable Stage III NSCLC

Lung Cancer Stage III
Sun Yat-sen University36 enrolled1 locationNCT03872661
Recruiting
Phase 2

Pulmonary Rehabilitation in Advanced Lung Cancer Survivors

Lung CancerNon-small Cell Lung CancerNon-Small Cell Lung Cancer (Stage III)+1 more
Case Comprehensive Cancer Center85 enrolled1 locationNCT07104630
Recruiting
Not Applicable

Avecure Flexible Microwave Ablation Probe For Lung Nodules

Lung CancerLung Cancer Stage ILung Cancer Stage II+3 more
Beth Israel Deaconess Medical Center10 enrolled1 locationNCT05281237
Recruiting
Not Applicable

Transthoracic vs Transbronchial Radiofrequency Ablation for Lung Cancer

Lung Cancer Stage IA
Shanghai Chest Hospital110 enrolled1 locationNCT06503744
Recruiting
Phase 1Phase 2

Alectinib Pharmacokinetic in Patients With NSCLC

ALK Gene MutationNon-small Cell Lung Cancer Stage IIIB
Instituto Nacional de Cancerologia de Mexico45 enrolled1 locationNCT05713006
Recruiting
Phase 2

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

Brain MetastasesNonsmall Cell Lung Cancer Stage III
Wake Forest University Health Sciences60 enrolled1 locationNCT05692635
Recruiting
Phase 2

Quick Start Durvalumab Following Chemoradiation for Stage III Nonsmall Cell Lung Cancer

Nonsmall Cell Lung Cancer Stage IIIUnresectable Non-Small Cell Lung CarcinomaNonsmall Cell Lung Cancer, Stage II
Wake Forest University Health Sciences28 enrolled1 locationNCT05696782
Recruiting
Phase 1Phase 2

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

Non-small Cell Lung Cancer (NSCLC)KRAS, NRAS, HRAS-mutated NSCLCKRAS G12C-mutated Solid Tumors, Lung Cancer+2 more
Revolution Medicines, Inc.616 enrolled89 locationsNCT06162221
Recruiting
Phase 2

A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease

Non-small Cell Lung CancerNSCLCNSCLC Stage II+5 more
Memorial Sloan Kettering Cancer Center25 enrolled7 locationsNCT07323732
Recruiting
Phase 2

A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

Non-small Cell Lung CancerNon-small Cell Lung Cancer Stage IINon-small Cell Lung Cancer Stage IIIB+1 more
Memorial Sloan Kettering Cancer Center14 enrolled10 locationsNCT07428044
Recruiting
Phase 2

Adjuvant ctDNA-Adapted Personalized Treatment in Early Stage NSCLC (ADAPT-E)

Non-small Cell Lung CancerNon-Small Cell Lung Cancer (Stage III)Non-small Cell Lung Cancer Stage I+1 more
Stanford University80 enrolled1 locationNCT04585477
Recruiting
Phase 2

Risk-adapted, Proteomic-guided Systemic Therapy for Previously Untreated Advanced Non-small Cell Lung Cancer

Non-small Cell Lung CancerNon-small Cell Lung Cancer MetastaticNon-small Cell Lung Cancer Stage IV+2 more
University of California, Davis56 enrolled1 locationNCT07250477
Recruiting
Early Phase 1

[177Lu]Lu-AKIR001 First-in-human Study

Thyroid Gland Anaplastic CarcinomaPoorly Differentiated Thyroid CarcinomaCancer Head and Neck+3 more
Karolinska University Hospital15 enrolled1 locationNCT06639191
Recruiting
Phase 2

Adding Certolizumab to Chemotherapy + Nivolumab in People Who Have Lung Cancer That Can Be Treated With Surgery

Lung CancerLung Cancer Stage IILung Cancer Stage III
Memorial Sloan Kettering Cancer Center60 enrolled7 locationsNCT04991025
Recruiting

Characteristics of Advanced LUNG CANCER at the tIme of Diagnosis in a Large Italian Cohor

Lung Cancer Stage IV
Fondazione Policlinico Universitario Agostino Gemelli IRCCS1,000 enrolled3 locationsNCT06076005
Recruiting
Phase 1Phase 2

AK129 Combination Therapy for Advanced Solid Tumors

Head and Neck Squamous Cell Carcinoma (HNSCC)Advanced Solid TumorsColorectal Adenocarcinoma+1 more
Akeso230 enrolled1 locationNCT06943820
Recruiting
Phase 3

Bovine Reinforcement in Stomach, Colorectal and Lung Operation

Rectal Cancer Stage IIILung Cancer Stage III
Shanghai Cingularbio Co. Ltd172 enrolled1 locationNCT06968221