Surfactant Clinical Trials

11 recruitingLast updated: May 21, 2026

There are 11 actively recruiting surfactant clinical trials across 19 countries. Studies span Not Applicable, Phase 4, Early Phase 1. Top locations include Bangui, Central African Republic, Brno, Czechia, Budapest, Hungary. Updated daily from ClinicalTrials.gov.


Surfactant Trials at a Glance

11 actively recruiting trials for surfactant are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 4 trials, with the heaviest enrollment activity in Bangui, Brno, and Budapest. Lead sponsors running surfactant studies include Connecticut Children's Medical Center, Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, and Children's Hospital of Fudan University.

Browse surfactant trials by phase

About Surfactant Clinical Trials

Looking for clinical trials for Surfactant? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Surfactant trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Surfactant clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 111 of 11 trials

Recruiting
Not Applicable

Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure

Neonatal Brain Injuryperinatal morbidityMechanical Ventilation+10 more
Medical College of Wisconsin320 enrolled1 locationNCT07274527
Recruiting
Phase 4

Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes

Cerebral oxygen saturationInfant Respiratory Distress SyndromeCerebral Oxygenation+3 more
Medical University of Graz76 enrolled1 locationNCT07261787
Recruiting
Phase 4

Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome

SurfactantRespiratory Distress Syndrome in Premature InfantsRespiratory Distress Syndrome (RDS)
Uludag University234 enrolled5 locationsNCT07350018
Recruiting
Phase 4

Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa

Premature BirthRespiratory Distress Syndrome in Premature InfantSurfactant Deficiency Syndrome Neonatal+1 more
Indiana University1,512 enrolled8 locationsNCT06554522
Recruiting
Early Phase 1

Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes

Interstitial Lung DiseaseSurfactant Dysfunction
Children's Hospital of Fudan University60 enrolled1 locationNCT04532346
Recruiting

Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)

Preterm BirthAcute Respiratory Distress SyndromeRespiratory distress syndrome+1 more
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University400 enrolled1 locationNCT04777760
Recruiting
Not Applicable

Surfactant Administration by Insure or Thin Catheter

AnalgesiaSurfactant Deficiency Syndrome NeonatalRDS of Prematurity
Karolinska Institutet160 enrolled1 locationNCT04445571
Recruiting
Not Applicable

Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure

Intensive Care Units, NeonatalRespiratory Distress Syndrome, NewbornPulmonary Surfactants
Connecticut Children's Medical Center52 enrolled1 locationNCT06446453
Recruiting

A Prospective Observational Study of Video Laryngoscopy Versus Direct Laryngoscopy for Insertion of a Thin Endotracheal Catheter for Surfactant Administration in Newborn Infants

Video LaryngoscopyRespiratory Distress Syndrome (Neonatal)Surfactant+1 more
University College Dublin600 enrolled16 locationsNCT06758492
Recruiting
Not Applicable

Infants with Severe Acute Respiratory Distress Syndrome: the Prone Trial

Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)Surfactant DysfunctionInfant
Medical University of Vienna14 enrolled1 locationNCT05002478
Recruiting
Phase 4

Premedication for Less Invasive Surfactant Administration

Surfactant Deficiency Syndrome Neonatal
University of Oulu40 enrolled1 locationNCT03735563