Phase 3 Symptom Clinical Trials
29 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 29 trials
Recruiting
Phase 3
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)
Chronic Inducible UrticariaCold UrticariaSymptomatic Dermographism+1 more
Celldex Therapeutics240 enrolled72 locationsNCT07266402
Recruiting
Phase 3
REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
Symptomatic Venous Thromboembolism (VTE)
Regeneron Pharmaceuticals2,000 enrolled16 locationsNCT07213778
Recruiting
Phase 2Phase 3
A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy
Symptomatic Genetic Dilated Cardiomyopathy
Kardigan, Inc.332 enrolled33 locationsNCT07210723
Recruiting
Phase 3
Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications
Negative Symptoms of Schizophrenia
Minerva Neurosciences380 enrolled2 locationsNCT07565428
Recruiting
Phase 3
Nebulized Ketamine for the Treatment of Major Depressive Disorder
MidazolamDepressive SymptomSevere Depression+14 more
Theresa Jacob, PhD, MPH40 enrolled1 locationNCT06752759
Recruiting
Phase 2Phase 3
A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).
PediatricSymptomatic Obstructive Hypertrophic Cardiomyopathy
Cytokinetics55 enrolled38 locationsNCT06412666
Recruiting
Phase 3
Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3
Opioid UseOpioid-use DisorderWithdrawal Symptoms
Emory University103 enrolled6 locationsNCT05834478
Recruiting
Phase 3
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms
Axsome Therapeutics, Inc.508 enrolled13 locationsNCT07484217
Recruiting
Phase 3
Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach
Parkinson's Disease (PD)Freezing of GaitFreezing of Gait Symptoms in Parkinson Disease
Radboud University Medical Center60 enrolled1 locationNCT07316296
Recruiting
Phase 3
Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries
Preterm BirthStillbirthSmall for Gestational Age (SGA)+1 more
NICHD Global Network for Women's and Children's Health1,134 enrolled7 locationsNCT06723392
Recruiting
Phase 3
Electroacupuncture for Chemotherapy-Induced GI Symptom Clusters in Breast Cancer
Standard Quadruple Antiemetic TherapyElectroacupunctureChemotherapy-induced Gastrointestinal Symptom Cluster
Jiuda Zhao388 enrolled1 locationNCT06952920
Recruiting
Phase 3
Saccharomyces Boulardii CNCM I-745 in Irritable Bowel Syndrome
IBS - Irritable Bowel SyndromeIBS-D (Diarrhea-predominant)IBS, Mixed Symptoms
Biocodex406 enrolled10 locationsNCT07168434
Recruiting
Phase 3
Home-based Cycling for People With Lumbar Spinal Stenosis
Symptomatic Lumbar Spinal Stenosis
Assistance Publique - Hôpitaux de Paris302 enrolled1 locationNCT04075539
Recruiting
Phase 3
Drug- Eluting Stent for Symptomatic Intracranial Arterial Stenosis
Symptomatic Intracranial Atherosclerotic Stenosis
Beijing Tiantan Hospital224 enrolled1 locationNCT07197970
Recruiting
Phase 3
Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT
Asymptomatic Brain MetastasesDriver Mutation Positive Non-small Cell Lung Cancer
Tata Memorial Hospital190 enrolled1 locationNCT05236946
Recruiting
Phase 3
Study of Tamsulosin, Solifenacin and Mirabegron in Alleviating Ureteral Stent-related Symptoms
Ureteral Stent-Related Symptom
Bir Hospital189 enrolled1 locationNCT06803030
Recruiting
Phase 3
Comparison of Alpha Blockers (Terazosin and Tamsulosin) in Reducing Ureteral Stent Related Symptoms
Stent Related Symptoms
Penang Hospital, Malaysia150 enrolled2 locationsNCT06966804
Recruiting
Phase 3
Early Initiated Vasopressor Therapy in the Emergency Department
HypotensionHypotension SymptomaticShock+5 more
Odense University Hospital320 enrolled8 locationsNCT05931601
Recruiting
Phase 2Phase 3
Efficacy of Tadalafil (5mg) For Treatment of Early Storage Symptoms and Erectile Dysfunction After Endoscopic Enucleation of Prostate
Erectile DysfunctionLower Urinary Tract Symptoms
Mansoura University110 enrolled1 locationNCT05955001
Recruiting
Phase 2Phase 3
Dog Presence and Oxytocin on Trust Towards Therapists
Depressive SymptomsHuman-Animal Interaction
Dr. Karin Hediger176 enrolled1 locationNCT06248710