Phase 2 Systemic Sclerosis Clinical Trials
34 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 34 trials
Recruiting
Phase 1Phase 2
RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis
SclerodermaSystemic Sclerosis
Cabaletta Bio12 enrolled10 locationsNCT06328777
Recruiting
Phase 2
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
Systemic Sclerosis (SSc)
argenx81 enrolled74 locationsNCT06655155
Recruiting
Phase 2
EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Diffuse Cutaneous Systemic Sclerosis
Mediar Therapeutics85 enrolled5 locationsNCT07287670
Recruiting
Phase 1Phase 2
Controlling Hyperactive Immunity With Long-lived Lymphocytes
Rheumatoid Arthritis (RA)Autoimmune Rheumatologic DiseaseDiffuse Cutaneous Systemic Sclerosis+1 more
Quell Therapeutics Limited16 enrolled6 locationsNCT07473154
Recruiting
Phase 1Phase 2
Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders
Systemic Lupus ErythematosusLupusAutoimmune Disorders+2 more
M.D. Anderson Cancer Center47 enrolled2 locationsNCT06434363
Recruiting
Phase 2
A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis
Progressive Pulmonary FibrosisInterstitial Lung DiseasePulmonary Fibrosis+4 more
Avalyn Pharma Inc.375 enrolled152 locationsNCT06329401
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
Idiopathic Inflammatory MyopathiesSystemic Sclerosis
Nkarta, Inc.144 enrolled15 locationsNCT06733935
Recruiting
Phase 2
A Study of Nemolizumab for the Treatment of Adults With Systemic Sclerosis
Systemic Sclerosis
Galderma R&D162 enrolled3 locationsNCT07047690
Recruiting
Phase 2
Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Systemic Sclerosis
Hospital for Special Surgery, New York30 enrolled1 locationNCT03844061
Recruiting
Phase 2
A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis
Diffuse Cutaneous Systemic Sclerosis
Novartis Pharmaceuticals200 enrolled127 locationsNCT06470048
Recruiting
Phase 1Phase 2
Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.
Refractory Lupus NephritisSystemic SclerosisPrimary Sjogren's Syndrome Combined With Pulmonary Hypertension
Beijing GoBroad Hospital45 enrolled1 locationNCT06947473
Recruiting
Phase 1Phase 2
CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH
Refractory Lupus NephritisSystemic SclerosisPrimary Sjogren's Syndrome Combined With Pulmonary Hypertension
Beijing GoBroad Hospital45 enrolled1 locationNCT06947460
Recruiting
Phase 2
Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)
SclerodermaSystemic Sclerosis (SSc)
Zura Bio Inc80 enrolled51 locationsNCT06843239
Recruiting
Phase 2Phase 3
A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
Scleroderma, SystemicSystemic Sclerosis Associated Interstitial Lung Disease
GlaxoSmithKline300 enrolled131 locationsNCT05878717
Recruiting
Phase 2
Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic Sclerosis
Digital Ulcers in Systemic Sclerosis
Topadur Pharma AG15 enrolled5 locationsNCT06954597
Recruiting
Phase 2
Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma.
Systemic Sclerosis
University Hospital, Toulouse32 enrolled7 locationsNCT04356755
Recruiting
Phase 2
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
Systemic Sclerosis (SSc)Refractory Rheumatoid Arthritis (RA)Idiopathic Inflammatory Myopathies (IIMs)
Artiva Biotherapeutics, Inc.90 enrolled26 locationsNCT06991114
Recruiting
Phase 2
Safety and Efficacy of Itacitinib in Adults With Systemic Sclerosis
Systemic Sclerosis
Assistance Publique - Hôpitaux de Paris74 enrolled46 locationsNCT04789850
Recruiting
Phase 2
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis
Interstitial Lung DiseasePulmonary HypertensionSystemic Sclerosis+1 more
Paul Szabolcs8 enrolled3 locationsNCT03630211
Recruiting
Phase 2
Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases
Systemic Lupus ErythematosusSystemic Sclerosis
Stephan Grupp MD PhD20 enrolled1 locationNCT05029336