Phase 1 THA Clinical Trials
46 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 46 trials
Recruiting
Phase 1Phase 2
Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
Beta-ThalassemiaSickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)90 enrolled1 locationNCT07599176
Recruiting
Phase 1
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
Sickle Cell DiseaseHb-SS DiseaseHemoglobin S+3 more
National Heart, Lung, and Blood Institute (NHLBI)25 enrolled1 locationNCT05904093
Recruiting
Phase 1
CPX-351 in Treating Patients With Relapsed or Refractory High Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia
Recurrent Chronic Myelomonocytic LeukemiaRefractory Chronic Myelomonocytic LeukemiaRecurrent High Risk Myelodysplastic Syndrome+4 more
M.D. Anderson Cancer Center38 enrolled1 locationNCT03896269
Recruiting
Phase 1Phase 2
A Study of AZD3470, a PRMT5 Inhibitor, Given as Monotherapy and in Combination in Patients With MTAP Deficient Advanced/Metastatic Solid Tumors
Advanced Solid Tumors That Are MTAP Deficient
AstraZeneca334 enrolled20 locationsNCT06130553
Recruiting
Phase 1Phase 2
Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome
Acute Myeloid LeukemiaRecurrent Myelodysplastic SyndromeRefractory Myelodysplastic Syndrome+4 more
M.D. Anderson Cancer Center52 enrolled1 locationNCT04128748
Recruiting
Phase 1Phase 2
ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia
Beta-Thalassemia
Children's Hospital of Philadelphia12 enrolled1 locationNCT06364774
Recruiting
Phase 1Phase 2
Vyxeos for Re-induction Treatment of Acute Myeloid Leukemia Patients With Persistent Disease After Induction
Refractory Acute Myeloid LeukemiaBlasts More Than 5 Percent of Bone Marrow Nucleated CellsPersistent Disease
Ohio State University Comprehensive Cancer Center28 enrolled2 locationsNCT04049539
Recruiting
Phase 1
Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies
Beta-ThalassemiaSickle Cell DiseaseSickle Cell Anemia (HbSS, or HbSβ-thalassemia0)+1 more
Daniel Bauer10 enrolled1 locationNCT06647979
Recruiting
Phase 1
A Phase 1 Study to Assess STP938 as a Monotherapy in Adults With High Risk Essential Thrombocythaemia
Essential Thrombocythaemia
Step Pharma, SAS20 enrolled13 locationsNCT06786234
Recruiting
Phase 1Phase 2
A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
Prader-Willi SyndromeHypothalamic ObesityPWS
Rhythm Pharmaceuticals, Inc.150 enrolled7 locationsNCT06239116
Recruiting
Phase 1Phase 2
An Open-label Study of a Gene Therapy Product (Vebeglogene Autotemcel) in Transfusion Dependent Beta-Thalassemia
Beta-Thalassemia
Lantu Biopharma6 enrolled2 locationsNCT06308159
Recruiting
Phase 1Phase 2
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
Diamond-Blackfan AnemiaSickle Cell Anemiabeta thalassemia major
Paul Szabolcs5 enrolled1 locationNCT03653338
Recruiting
Phase 1Phase 2
Transdermal Microneedle Lignocaine Delivery Versus EMLA Patch for Topical Analgesia Before Venepuncture Procedure To Adults in Clinical Setting
CataractGlaucomaOphthalmological Disorder
Universiti Kebangsaan Malaysia Medical Centre154 enrolled1 locationNCT05694858
Recruiting
Phase 1Phase 2
Β-Thalassemia Treatment with KL003 Cell Injection
Transfusion Dependent Beta-Thalassemia
Kanglin Biotechnology (Hangzhou) Co., Ltd.41 enrolled2 locationsNCT06280378
Recruiting
Phase 1
A Multiple Ascending Dose Study of 9MW3011 in Patients With Non-transfusion-dependent β-thalassemia
Beta-Thalassemia
Mabwell (Shanghai) Bioscience Co., Ltd.40 enrolled2 locationsNCT06772766
Recruiting
Phase 1
Evaluating Safety and Efficacy of Lentiviral-transduced CD34+ HSCs in Β-thalassaemia Patients.
Thalassemia
Shenzhen Hemogen8 enrolled3 locationsNCT06655662
Recruiting
Phase 1
Clinical Study for the Evaluation of Safety and Tolerability of NCP112 Eye Drops
Xerophthalmia
Huons Co., Ltd.60 enrolled1 locationNCT06263998
Recruiting
Phase 1
A Phase 1 Study of Gene-modified Autologous Hematopoietic Stem Cell (BD211) Treating β-thalassemia Major
Thalassemia
Shanghai BDgene Co., Ltd.9 enrolled3 locationsNCT06465550
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of betamethsone ointment applied to the skin in healthy male and female volunteers.
Betamethasone ointment is indicated for the topical treatment of eczema and psoriasis in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12624000107527
Recruiting
Phase 1Phase 2
Thal-Fabs: Reduced Toxicity Conditioning for High Risk Thalassemia
Thalassemia in Children
The Hospital for Sick Children20 enrolled1 locationNCT05426252