TMD Clinical Trials

26 recruitingLast updated: May 21, 2026

There are 26 actively recruiting tmd clinical trials across 10 countries. Studies span Not Applicable, Early Phase 1, Phase 3. Top locations include Minneapolis, Minnesota, United States, Huddinge, Sweden, Gainesville, Florida, United States. Updated daily from ClinicalTrials.gov.


TMD Trials at a Glance

26 actively recruiting trials for tmd are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Not Applicable with 17 trials, with the heaviest enrollment activity in Minneapolis, Huddinge, and Gainesville. Lead sponsors running tmd studies include Karolinska Institutet, University of Minnesota, and University of Florida.

Browse tmd trials by phase

About TMD Clinical Trials

Looking for clinical trials for TMD? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new TMD trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about TMD clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 26 trials

Recruiting

Exploration of the Utility of Dental-dedicated MRI for Dentistry

orthodonticsDental CrowdingEndodontic Disease+5 more
University of Minnesota300 enrolled1 locationNCT06948162
Recruiting
Not Applicable

A Double-blind, Placebo-controlled Evaluation of the Effect of the Erchonia® EVRL on Chronic Jaw Pain Arising From TMJ

TMJ PainTMDTMJ
Erchonia Corporation64 enrolled1 locationNCT07600203
Recruiting
Not Applicable

Peloid Therapy in Temporomandibular Joint Dysfunction

PainTemporomandibular Disorders (TMDs)Otalgia
Uşak University40 enrolled1 locationNCT07576582
Recruiting
Not Applicable

Occlusal Splint and Exercise Therapy for Temporomandibular Disorders

Temporomandibular Disorders (TMD)
Acibadem University38 enrolled1 locationNCT07507734
Recruiting
Not Applicable

Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular Disorders

Temporomandibular disorder (TMD)Temporomandibular Disorders (TMD)TMD/Orofacial Pain+4 more
Semmelweis University90 enrolled2 locationsNCT07474662
Recruiting
Not Applicable

Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement

Temporomandibular Disorders (TMD)Internal Derangement of the Tempromandibular JointAnterior Disc Displacement
Horus University32 enrolled1 locationNCT07075276
Recruiting

Occlusal Equilibration vs. Sham Therapies for TMDs: Post-Trial Follow-up (OEST)

Temporomandibular Disorders (TMD)Myalgia of Mastication MuscleArthralgia Syndrome
Urbano Santana Penin110 enrolled2 locationsNCT07445516
Recruiting
Early Phase 1

JIT: Effect of Pain on DT in TMD

Temporomandibular disorder (TMD)
University of Minnesota160 enrolled1 locationNCT06659991
Recruiting

Virtual Planning of Total Temporomandibular Joint Replacement

Temporomandibular Disorders (TMD)Temporomandibular Joint Ankylosis
Lund University Hospital30 enrolled1 locationNCT07373184
Recruiting
Not Applicable

Two Treatment Modalities for Myogenous Temporomandibular Disorders

TMD
Alexandria University32 enrolled1 locationNCT07351812
Recruiting
Not Applicable

Journaling Intervention for Temporomandibular Disorder (TMD) and Chronic Overlapping Pain

Temporomandibular Disorders (TMD)
University of Florida60 enrolled1 locationNCT06977100
Recruiting
Not Applicable

Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions

TMDTMD/Orofacial Pain
Tayfun ISIK48 enrolled1 locationNCT07304557
Recruiting

Long-term Follow up of TMJ Surgery and Evaluation of the 6-month Control as a Prognostic Marker.

Temporomandibular Disorders (TMD)Temporomandibular Joint Disc Displacement, Without ReductionTemporomandibular Joint Disc Displacement, With Reduction
Karolinska Institutet91 enrolled1 locationNCT06782165
Recruiting
Not Applicable

Orofacial Pain Self-management: Personality Moderation Effect

Temporomandibular disorder (TMD)Temporomandibular Disorders (TMD)Chronic Orofacial Pain+1 more
Fundación Universidad Católica de Valencia San Vicente Mártir98 enrolled1 locationNCT06932406
Recruiting
Not Applicable

Photobiomodulation for Management of Temporomandibular Disorder Pain

Pain Related to TMD
University of Florida130 enrolled1 locationNCT05916235
Recruiting
Not Applicable

Treatment of Temporomandibular Joint Disorders With a Stabilizing Occlusal Splint in Somatosensory Tinnitus

TinnitusTemporomandibular Disorders (TMD)TMJ
University of Sao Paulo General Hospital63 enrolled1 locationNCT07211711
Recruiting
Not Applicable

The Effect of Non-Invasive Vagal Nerve Stimulation Combined With Self-Managed Therapy in Individuals With Myogenic Temporomandibular Dysfunction

Temporomandibular Disorders (TMD)
Toros University48 enrolled1 locationNCT06802445
Recruiting

Endogenous Pain Inhibition Deficiency in Chronic TMD Pain

Chronic Temporomandibular Disorders (TMD)
University of Minnesota40 enrolled1 locationNCT06617494
Recruiting
Not Applicable

TMJ Arthroscopic Lysis and Lavage Compared to Operative Arthroscopy in Disc Displacement With Reduction.

Temporomandibular Disorders (TMD)Temporomandibular Joint Disc Displacement, With Reduction
Karolinska Institutet96 enrolled1 locationNCT06782191
Recruiting
Not Applicable

TMJ Arthroscopy Compared to Arthrocentesis in Disc Displacement Without Reduction

Temporomandibular Disorders (TMD)Temporomandibular Joint Disc DisplacementTemporomandibular Joint Disc Displacement, Without Reduction
Karolinska Institutet100 enrolled1 locationNCT06782178