Phase 1 TME Clinical Trials
81 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 81 trials
Recruiting
Phase 1
Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors
Advanced Solid TumorAdvanced Solid Tumors Appropriate for Treatment With Either Nivolumab or Pembrolizumab
Vaxiion Therapeutics48 enrolled7 locationsNCT05901285
Recruiting
Phase 1Phase 2
Venetoclax in Combination With Ivosidenib and Azacitidine for Newly Diagnosed IDH1-Mutated AML
TreatmentAMLIDH1 Mutation
Institute of Hematology & Blood Diseases Hospital, China23 enrolled1 locationNCT06611839
Recruiting
Phase 1
Restoration of Antibiotics Related Infant Microbiota Perturbations by Autologous Fecal Transplant
Antibiotic Treatment
Rutgers, The State University of New Jersey100 enrolled1 locationNCT06609980
Recruiting
Phase 1
Phase I, Open-labeled, Dose-escalation, Dose-expansion Study Evaluating the Safety, Tolerance, Pharmacokinetics, and Activity of IUAb190708 in Patients With Advanced or Recurrent Solid Tumors
Solid Tumor CancerSolid Tumor Cancer Treatment With Immunotherapy
Jun Zhou90 enrolled6 locationsNCT07584954
Recruiting
Phase 1Phase 2
Personalized Ultrasonic Brain Stimulation for Depression (R61)
Depression - Major Depressive DisorderMajor Depressive EpisodeTreatment-Resistant Major Depressive Disorder
Brian Mickey30 enrolled1 locationNCT06902298
Recruiting
Phase 1
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Depressive Disorder, MajorDepressive Disorder, Treatment-Resistant
Washington University School of Medicine60 enrolled1 locationNCT02994433
Recruiting
Phase 1Phase 2
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).
ParagangliomaPheochromocytomaSolid Tumor Cancer+17 more
Fundación de investigación HM25 enrolled1 locationNCT06607692
Recruiting
Phase 1Phase 2
A Clinical Trial of EHT102 Injection in Pediatric Patients With Biallelic hOTOF Mutations
Treatment of Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
Shanghai Euhearing Therapeutics Co., Ltd30 enrolled1 locationNCT07288580
Recruiting
Phase 1
A Phase 1 Study of OTS-412 (Recombinant Oncolytic Vaccinia Virus) in Treatment-refractory Solid Tumor Patients (South Korea)
Treatment-Refractory Solid Tumors
Bionoxx Inc.27 enrolled2 locationsNCT07190833
Recruiting
Phase 1Phase 2
Ceftriaxone for Post-Treatment Lyme Disease
Post-treatment Lyme Disease Syndrome
Hackensack Meridian Health20 enrolled1 locationNCT06785402
Recruiting
Phase 1
Psilocybin for Treatment-Resistant Depression in Autism
Autism Spectrum DisorderTreatment Resistant Depression
Centre for Addiction and Mental Health20 enrolled1 locationNCT06731621
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine
Acute Treatment of Migraine
Pfizer16 enrolled13 locationsNCT06995729
Recruiting
Phase 1Phase 2
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Myalgic EncephalomyelitisChronic Fatigue SyndromePost-treatment Lyme Disease Syndrome+1 more
Icahn School of Medicine at Mount Sinai120 enrolled1 locationNCT06511050
Recruiting
Phase 1
Venetoclax Basket Trial for High Risk Hematologic Malignancies
Acute Lymphoblastic Leukemia, in RelapseAcute Leukemia of Ambiguous LineageAcute Lymphoblastic Leukemia With Failed Remission+8 more
Andrew E. Place, MD30 enrolled5 locationsNCT05292664
Recruiting
Phase 1
A First-in-human Trial of GRT7041 in Healthy Participants
Treatment of Pain
Grünenthal GmbH70 enrolled1 locationNCT07289776
Recruiting
Phase 1
Multiple Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of KSHN001034 in Healthy Postmenopausal Female Volunteers
Healthy Postmenopausal Women
Kashiv BioSciences, LLC40 enrolled2 locationsNCT06995482
Recruiting
Phase 1
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
HealthyMajor Depressive DisorderTreatment Resistant Depression
Baylor College of Medicine100 enrolled2 locationsNCT06480201
Recruiting
Phase 1
Romiplostim N01 for Platelet Recovery After Haploidentical HSCT
Acute Myeloid LeukemiaHSCTMDS (Myelodysplastic Syndrome)+1 more
First Affiliated Hospital of Zhejiang University130 enrolled1 locationNCT07321626
Recruiting
Phase 1
DBS for Depression
Treatment Resistant Depression
Northwell Health20 enrolled1 locationNCT06096207
Recruiting
Phase 1
A Randomized, Double-blind, Placebo-controlled, Single and Multiple Dose Escalation Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of IMC-003 for Injection in Healthy Postmenopausal Women
Healthy Postmenopausal Women
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.56 enrolled1 locationNCT07118085