Phase 1 TME Clinical Trials
88 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 88 trials
Recruiting
Phase 1
Phase 1 Study Of SAR445877 In Combination With FOLFOX6 And Bevacizumab As First-Line Treatment For Microsatellite Stable Metastatic Colorectal Cancer
First-line TreatmentMetastatic Colorectal Cancer (CRC)Phase 1+4 more
M.D. Anderson Cancer Center41 enrolled1 locationNCT07500298
Recruiting
Phase 1
Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females
postmenopausal osteoporosisMenopauseGut Microbiome
University of Connecticut159 enrolled1 locationNCT07365514
Recruiting
Phase 1
To Test a New Drug (LCFA-01) for Safety and PK in Healthy Adults for Bacterial Vaginosis Infection.
Bacterial Vaginosis Treatment
Massachusetts General Hospital30 enrolled1 locationNCT07514416
Recruiting
Phase 1Phase 2
Cannabidiol Oil for Treatment-Resistant Major Depression
Major Depressive Disorder (MDD)Treatment Resistant Depression (TRD)
Universidade do Sul de Santa Catarina120 enrolled1 locationNCT07696871
Recruiting
Phase 1
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
HealthyMajor Depressive DisorderTreatment Resistant Depression
Texas A&M University100 enrolled2 locationsNCT06480201
Recruiting
Phase 1
Zorifertinib With Osimertinib for NSCLC With Meningeal Progression
Patients With Advanced Non-small Cell Lung Cancer With Meningeal Progression After Osimertinib Treatment
Alpha Biopharma (Jiangsu) Co., Ltd.42 enrolled5 locationsNCT07361705
Recruiting
Phase 1
Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
Intracanal MedicationIntervention StudiesASA Physical Status I+2 more
Ain Shams University60 enrolled1 locationNCT07641933
Recruiting
Phase 1
DBS for Depression
Treatment Resistant Depression
Northwell Health20 enrolled1 locationNCT06096207
Recruiting
Phase 1Phase 2
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).
ParagangliomaPheochromocytomaSolid Tumor Cancer+19 more
Fundación de investigación HM25 enrolled1 locationNCT06607692
Recruiting
Phase 1
To Evaluate the Impact of Smoking on PK After Single-dose Oral Administration of GS1-144 Tablets .
Postmenopause
Changchun GeneScience Pharmaceutical Co., Ltd.24 enrolled1 locationNCT07534176
Recruiting
Phase 1
Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors
Advanced Solid TumorAdvanced Solid Tumors Appropriate for Treatment With Either Nivolumab or Pembrolizumab
Vaxiion Therapeutics48 enrolled7 locationsNCT05901285
Recruiting
Phase 1Phase 2
Venetoclax in Combination With Ivosidenib and Azacitidine for Newly Diagnosed IDH1-Mutated AML
TreatmentAMLIDH1 Mutation
Institute of Hematology & Blood Diseases Hospital, China23 enrolled1 locationNCT06611839
Recruiting
Phase 1
Restoration of Antibiotics Related Infant Microbiota Perturbations by Autologous Fecal Transplant
Antibiotic Treatment
Rutgers, The State University of New Jersey100 enrolled1 locationNCT06609980
Recruiting
Phase 1
Phase I, Open-labeled, Dose-escalation, Dose-expansion Study Evaluating the Safety, Tolerance, Pharmacokinetics, and Activity of IUAb190708 in Patients With Advanced or Recurrent Solid Tumors
Solid Tumor CancerSolid Tumor Cancer Treatment With Immunotherapy
Jun Zhou90 enrolled6 locationsNCT07584954
Recruiting
Phase 1Phase 2
Personalized Ultrasonic Brain Stimulation for Depression (R61)
Depression - Major Depressive DisorderMajor Depressive EpisodeTreatment-Resistant Major Depressive Disorder
Brian Mickey30 enrolled1 locationNCT06902298
Recruiting
Phase 1
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Depressive Disorder, MajorDepressive Disorder, Treatment-Resistant
Washington University School of Medicine60 enrolled1 locationNCT02994433
Recruiting
Phase 1Phase 2
A Clinical Trial of EHT102 Injection in Pediatric Patients With Biallelic hOTOF Mutations
Treatment of Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
Shanghai Euhearing Therapeutics Co., Ltd30 enrolled1 locationNCT07288580
Recruiting
Phase 1
A Phase 1 Study of OTS-412 (Recombinant Oncolytic Vaccinia Virus) in Treatment-refractory Solid Tumor Patients (South Korea)
Treatment-Refractory Solid Tumors
Bionoxx Inc.27 enrolled2 locationsNCT07190833
Recruiting
Phase 1Phase 2
Ceftriaxone for Post-Treatment Lyme Disease
Post-treatment Lyme Disease Syndrome
Hackensack Meridian Health20 enrolled1 locationNCT06785402
Recruiting
Phase 1
Psilocybin for Treatment-Resistant Depression in Autism
Autism Spectrum DisorderTreatment Resistant Depression
Centre for Addiction and Mental Health20 enrolled1 locationNCT06731621